Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison
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Title
Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison
Authors
Keywords
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Journal
Frontiers in Neurology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-05-24
DOI
10.3389/fneur.2021.662838
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Note: Only part of the references are listed.- Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset
- (2021) Nancy J. Newman et al. OPHTHALMOLOGY
- Safety of Intravitreal Gene Therapy for Treatment of Subjects with Leber Hereditary Optic Neuropathy due to Mutations in the Mitochondrial ND4 Gene: The REVEAL Study
- (2021) Catherine Vignal-Clermont et al. BIODRUGS
- Natural history of patients with Leber hereditary optic neuropathy—results from the REALITY study
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- Seven Years Follow-up of Gene Therapy for Leber's Hereditary Optic Neuropathy
- (2020) Jiajia Yuan et al. OPHTHALMOLOGY
- Visual Outcomes in Leber Hereditary Optic Neuropathy Patients With the m.11778G>A (MTND4) Mitochondrial DNA Mutation
- (2020) Nancy J. Newman et al. JOURNAL OF NEURO-OPHTHALMOLOGY
- Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy
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- Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy
- (2020) Patrick Yu-Wai-Man et al. Science Translational Medicine
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- (2019) Sarah Goring et al. BMJ Open
- What are the characteristics and progression of visual field defects in patients with Leber hereditary optic neuropathy: a prospective single-centre study in China
- (2019) Hong-Li Liu et al. BMJ Open
- Clinical and Optic Disc Characteristics of Patients Showing Visual Recovery in Leber Hereditary Optic Neuropathy
- (2019) Yeji Moon et al. JOURNAL OF NEURO-OPHTHALMOLOGY
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- (2018) Nicole Balducci et al. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Safety of rAAV2/2- ND4 Gene Therapy for Leber Hereditary Optic Neuropathy
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- International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy
- (2017) Valerio Carelli et al. JOURNAL OF NEURO-OPHTHALMOLOGY
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- (2017) Tiffany Jean Hwang et al. OPHTHALMOLOGY
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- (2017) John Guy et al. OPHTHALMOLOGY
- A neurodegenerative perspective on mitochondrial optic neuropathies
- (2016) Patrick Yu-Wai-Man et al. ACTA NEUROPATHOLOGICA
- Evaluation of Leberʼs hereditary optic neuropathy patients prior to a gene therapy clinical trial
- (2016) Shuo Yang et al. MEDICINE
- Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss
- (2015) Hélène Cwerman-Thibault et al. Molecular Therapy-Methods & Clinical Development
- Trial End Points and Natural History in Patients With G11778A Leber Hereditary Optic Neuropathy
- (2014) Byron L. Lam et al. JAMA Ophthalmology
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- (2013) Erika F. Augustine et al. JOURNAL OF CHILD NEUROLOGY
- A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy
- (2011) Thomas Klopstock et al. BRAIN
- Very high penetrance and occurrence of Leber’s hereditary optic neuropathy in a large Han Chinese pedigree carrying the ND4 G11778A mutation
- (2010) Xiangtian Zhou et al. MOLECULAR GENETICS AND METABOLISM
- Extremely Low Penetrance of Leber's Hereditary Optic Neuropathy in 8 Han Chinese Families Carrying the ND4 G11778A Mutation
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- Resolving the clinical acuity categories “hand motion” and “counting fingers” using the Freiburg Visual Acuity Test (FrACT)
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