Benzodiazepine Derivatives as Potent Vasopressin V2 Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease

Long Residence Time at the Vasopressin V2 Receptor Translates into Superior Inhibitory Effects in Ex Vivo and In Vivo Models of Autosomal Dominant Polycystic Kidney Disease

(2022) Haoran Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule

(2021) Attila Egyed et al.   BIOORGANIC CHEMISTRY

Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist

(2021) Bingfa Sun et al.   Nature Communications

Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective

(2020) Chunji Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury

(2020) Andrew Gibson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions

(2019) Talieh Malekshahabi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

(2019) Rainer Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autosomal dominant polycystic kidney disease

(2019) Emilie Cornec-Le Gall et al.   LANCET

Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes

(2019) Yi Yun et al.   BIOCHEMICAL PHARMACOLOGY

A two-state model for the kinetics of competitive radioligand binding

(2018) Dong Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model

(2018) Yangyang Zhu et al.   Food & Function

Recent Advances in the Management of Autosomal Dominant Polycystic Kidney Disease

(2018) Fouad T. Chebib et al.   Clinical Journal of the American Society of Nephrology

LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism

(2018) Marie-Céline Frantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polycystic kidney disease

(2018) Carsten Bergmann et al.   Nature Reviews Disease Primers

Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active Form

(2017) Hidetsugu Tabata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ganoderma triterpenes retard renal cyst development by downregulating Ras/MAPK signaling and promoting cell differentiation

(2017) Limin Su et al.   KIDNEY INTERNATIONAL

Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease

(2017) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

(2017) Justyna Ciolek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

(2017) Merrie Mosedale et al.   TOXICOLOGICAL SCIENCES

Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach

(2017) Merrie Mosedale et al.   TOXICOLOGICAL SCIENCES

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database

(2015) Paul B. Watkins et al.   DRUG SAFETY

Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling

(2015) Weiling Wang et al.   FASEB JOURNAL

Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease

(2013) V. E. Torres et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cyclic AMP-mediated cyst expansion

(2010) Darren P. Wallace   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Subtlety of the Structure−Affinity and Structure−Efficacy Relationships around a Nonpeptide Oxytocin Receptor Agonist

(2010) Marie-Céline Frantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

Vasopressin Directly Regulates Cyst Growth in Polycystic Kidney Disease

(2007) X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY