miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling

(2017) Brenton R. Ware et al.   TOXICOLOGICAL SCIENCES

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

(2017) Sachin Hajarnis et al.   Nature Communications

How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction

(2016) Tiffany Cho et al.   CHEMICAL RESEARCH IN TOXICOLOGY

APSN young investigator award - Basic science

(2016)   NEPHROLOGY

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

(2016) Natalie S. Holman et al.   TOXICOLOGICAL SCIENCES

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

(2016) Jeffrey L. Woodhead et al.   TOXICOLOGICAL SCIENCES

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Mechanisms of tolvaptan-induced toxicity in HepG2 cells

(2015) Yuanfeng Wu et al.   BIOCHEMICAL PHARMACOLOGY

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database

(2015) Paul B. Watkins et al.   DRUG SAFETY

Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease

(2015) Patricia Munoz-Garrido et al.   JOURNAL OF HEPATOLOGY

Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver

(2015) Matthew D. Davidson et al.   TISSUE ENGINEERING PART C-METHODS

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

(2015) Brenton R. Ware et al.   TOXICOLOGICAL SCIENCES

Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS

(2015) Fatemeh Momen-Heravi et al.   Scientific Reports

A Micropatterned Hepatocyte Coculture Model for Assessment of Liver Toxicity Using High-Content Imaging Analysis

(2014) O. Joseph Trask et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Genetic Basis of Drug-Induced Liver Injury: Present and Future

(2014) Thomas Urban et al.   SEMINARS IN LIVER DISEASE

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Short-term renal hemodynamic effects of tolvaptan in subjects with autosomal dominant polycystic kidney disease at various stages of chronic kidney disease

(2013) Wendy E. Boertien et al.   KIDNEY INTERNATIONAL

Importance of RNA isolation methods for analysis of exosomal RNA: Evaluation of different methods

(2012) Maria Eldh et al.   MOLECULAR IMMUNOLOGY

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

(2012) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

(2012) Salman R. Khetani et al.   TOXICOLOGICAL SCIENCES

A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models

(2012) Alison H. Harrill et al.   TOXICOLOGICAL SCIENCES

Effects of CYP3A4 inhibition and induction on the pharmacokinetics and pharmacodynamics of tolvaptan, a non-peptide AVP antagonist in healthy subjects

(2011) Susan E. Shoaf et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Nonclinical Pharmacokinetics of a New Nonpeptide V2 Receptor Antagonist, Tolvaptan

(2011) Masayuki Furukawa et al.   CARDIOVASCULAR DRUGS AND THERAPY

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

(2010) Barbara A. Wetmore et al.   HEPATOLOGY

Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)

(2010) Evan M. Kroh et al.   METHODS

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES