Makatoxin-3, a thermostable Nav1.7 agonist from Buthus martensii Karsch (BmK) scorpion elicits non-narcotic analgesia in inflammatory pain models

A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7

(2021) Donald Iain MacDonald et al.   NEURON

A Buthus martensii Karsch scorpion sting targets Nav1.7 in mice and mimics a phenotype of human chronic pain

(2021) Wuguang Lu et al.   PAIN

Traditional Chinese medicine Lingguizhugan decoction treating non-alcoholic fatty liver disease with spleen-yang deficiency pattern: Study protocol for a multicenter randomized controlled trial

(2020) Jingjuan Xu et al.   Trials

The Two Sides of NaV1.7: Painful and Painless Channelopathies

(2019) Stephen G. Waxman et al.   NEURON

The Role of Voltage-Gated Sodium Channels in Pain Signaling

(2019) David L. Bennett et al.   PHYSIOLOGICAL REVIEWS

Thermostable potassium channel-inhibiting neurotoxins in processed scorpion medicinal material revealed by proteomic analysis: Implications of its pharmaceutical basis in traditional Chinese medicine

(2019) Fan Yang et al.   Journal of Proteomics

Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy

(2018) Aoibhinn McDonnell et al.   PAIN

Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist

(2018) Viola Spahn et al.   Scientific Reports

Facile synthesis of macrocyclic peptide toxins of GpTx-1 and its analogue

(2018) Chao Chen et al.   Organic Chemistry Frontiers

GpTx-1 and [Ala5 , Phe6 , Leu26 , Arg28 ]GpTx-1, two peptide NaV 1.7 inhibitors: analgesic and tolerance properties at the spinal level

(2018) Chao Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

A mutant of theButhus martensiiKarsch antitumor-analgesic peptide exhibits reduced inhibition to hNav1.4 and hNav1.5 channels while retaining analgesic activity

(2017) Yijia Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1 channel mediates organophosphate-induced delayed neuropathy

(2017) Qiang Ding et al.   Cell Discovery

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

(2016) Edward C Emery et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

(173) A retrospective review of analgesic therapy for acute rib fractures and risk factors for development of chronic pain post fracture

(2016) A. Chopra et al.   JOURNAL OF PAIN

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

(2016) Jennifer Deuis et al.   Toxins

Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic

(2015) Hai-nan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

(2015) Michael S. Minett et al.   Nature Communications

An Overview of Animal Models of Pain: Disease Models and Outcome Measures

(2013) Nicholas S. Gregory et al.   JOURNAL OF PAIN

Mapping the receptor site for  -scorpion toxins on a Na+ channel voltage sensor

(2011) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analgesic efficacy and adverse effects of epidural morphine compared to parenteral opioids after elective caesarean section: A systematic review

(2010) Marie-Pierre Bonnet et al.   EUROPEAN JOURNAL OF PAIN

Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E2 release in the spinal cord

(2003) Irmgard Tegeder et al.   JOURNAL OF NEUROCHEMISTRY