Article
Critical Care Medicine
Ravindran Visagan, Florence R. A. Hogg, Mathew J. Gallagher, Siobhan Kearney, Argyro Zoumprouli, Marios C. Papadopoulos, Samira Saadoun
Summary: This study examines the feasibility of monitoring tissue oxygen tension in patients with acute, severe traumatic spinal cord injuries. The results show that tissue oxygen tension is influenced by various factors, including intraspinal pressure, spinal cord perfusion pressure, tissue glucose levels, lactate/pyruvate ratio, and fever. In patients with motor-incomplete injuries, fluctuations in tissue oxygen tension correlate with fluctuations in limb motor score.
CRITICAL CARE MEDICINE
(2022)
Article
Neurosciences
Hirosato Kanda, Kimiko Kobayashi, Hiroki Yamanaka, Masamichi Okubo, Yi Dai, Koichi Noguchi
Summary: The study revealed that nerve injury upregulates mPGES-1 mRNA in spinal endothelial cells, and EP2 and EP4 receptors are expressed in spinal neurons under neuropathic pain conditions.
Article
Biochemistry & Molecular Biology
Likang Lyu, Ru Wang, Haishen Wen, Yun Li, Jianshuang Li, Xiaojie Wang, Yijia Yao, Jifang Li, Xin Qi
Summary: This study utilized black rockfish as a model species to investigate the potential roles of cox1 and cox2 genes in mating and parturition behavior. The two genes were found to be mainly expressed in the heart, testis, and ovary, suggesting their important roles in mating and parturition processes. In situ hybridization further confirmed their involvement in mating and parturition behavior at the molecular level.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Zili He, Jiqing Du, Yu Zhang, Yitie Xu, Qian Huang, Qingwei Zhou, Min Wu, Yao Li, Xie Zhang, Hongyu Zhang, Yuepiao Cai, Keyong Ye, Xiangyang Wang, Yingze Zhang, Qi Han, Jian Xiao
Summary: Increasing evidence suggests that defects in autophagy and autophagy-lysosomal pathway (ALP) may contribute to endothelial barrier disruption following acute traumatic spinal cord injury (SCI). This study investigates whether Kruppel-like factor 2 (KLF2) coordinates ALP in endothelial cells in SCI. The results demonstrate that KLF2 is a key contributor to SCI-mediated ALP dysfunction and blood-spinal cord barrier (BSCB) disruption, and could be a promising pharmacological target for SCI management and treatment.
Review
Biochemistry & Molecular Biology
Dimitrios Kotsos, Konstantinos Tziomalos
Summary: Nonalcoholic fatty liver disease (NAFLD) is common in the general population and even more prevalent in obese and diabetic patients. NAFLD, especially nonalcoholic steatohepatitis (NASH), increases the risk for liver-related and cardiovascular morbidity. The development and progression of NAFLD involve complex and multifactorial pathogenesis, with potential involvement of microsomal prostaglandin E synthase-1 and -2. Targeting these enzymes may offer a novel therapeutic approach for NAFLD. This review discusses the association between microsomal prostaglandin E synthase-1 and -2 and NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Florence R. A. Hogg, Siobhan Kearney, Argyro Zoumprouli, Marios C. Papadopoulos, Samira Saadoun
Summary: This study observed the relationship between monitored physiological and metabolic parameters and changes in limb power in patients with spinal cord injuries. Significant causal links were found between different parameters, and multiple vicious cycles exacerbating cord damage were revealed. Monitoring and intervening to normalize these parameters could potentially improve limb power.
NEUROCRITICAL CARE
(2021)
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Xiaoping Ren, Weihua Zhang, Jie Qin, Jian Mo, Yi Chen, Jie Han, Xinjian Feng, Sitan Feng, Haibo Liang, Liangjue Cen, Xiaofei Wu, Linxuan Han, Rongyu Lan, Haixuan Deng, Huihui Yao, Zhongquan Qi, Hongjun Gao, Lishan Wei, Shuai Ren
Summary: This study tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal models and developed a new clinical procedure called vascular pedicle hemisected spinal cord transplantation (vSCT) for the treatment of paraplegic patients. The results demonstrated the feasibility and efficacy of vSCT in re-establishing the continuity of spinal nerve fibers, potentially restoring motor, sensory, and autonomic nervous functions in paraplegic patients. Further clinical trials are needed to validate these findings.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Article
Pharmacology & Pharmacy
Alexander Emil Kaspersen, Pelle Hanberg, Magnus A. Hvistendahl, Mats Bue, Anne Vibeke Schmedes, Kristian Hoy, Maiken Stilling
Summary: Optimal antibiotic prophylaxis is crucial to prevent postoperative infection in spinal surgery. We assessed cefuroxime concentrations and fT > MIC of 4 mu g center dot ml(-1) for relevant bacteria in the intrathecal and extrathecal compartments of the lumbar spine. The results showed that fT > MIC for cefuroxime was lower in the intrathecal compartments than in the extrathecal compartment, suggesting a significant effect of the blood-brain barrier.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Immunology
Xin-Qiang Yao, Jia-Ying Chen, Zi-Han Yu, Zu-Cheng Huang, Regan Hamel, Yong-Qiang Zeng, Zhi-Ping Huang, Ke-Wu Tu, Jun-Hao Liu, Yan-Meng Lu, Zhi-Tao Zhou, Stefano Pluchino, Qing-An Zhu, Jian-Ting Chen
Summary: The study identified APOE as a crucial hub gene in macrophages and microglia following spinal cord injury, playing a key role in neuroinflammation and recovery. Knocking out APOE exacerbated neurological dysfunction, increased neuroinflammation, and worsened white matter loss.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Angel Lanas, Stefania Tacconelli, Annalisa Contursi, Elena Piazuelo, Annalisa Bruno, Maurizio Ronci, Simone Marcone, Melania Dovizio, Federico Sopena, Lorenza Falcone, Cristina Milillo, Matteo Mucci, Patrizia Ballerini, Paola Patrignani
Summary: This study conducted a clinical study on eight FAP patients treated with low-dose Aspirin, and found that although it appropriately inhibited platelet production, there was still high synthesis of TXA(2) and PGE(2) in normal colon tissues and adenomas, indicating the need for other treatment methods to block the effects of these substances.
Article
Multidisciplinary Sciences
Masahito Masato, Yasuyoshi Miyata, Hiroki Kurata, Hidenori Ito, Kensuke Mitsunari, Akihiro Asai, Yuichiro Nakamura, Kyohei Araki, Yuta Mukae, Tsuyoshi Matsuda, Junki Harada, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai
Summary: In this study using a mouse model of prostate cancer, it was found that feeding with the EP1 receptor antagonist delayed cancer progression by increasing apoptosis, resulting in a lower incidence of cancer and a lower percentage of poorly differentiated cancer cells in the experimental group compared to the control group at different time points. The results suggest that the EP1 receptor antagonist may be a novel chemopreventive agent for prostate cancer.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Katja Zschiebsch, Caroline Fischer, Annett Wilken-Schmitz, Gerd Geisslinger, Keith Channon, Katrin Watschinger, Irmgard Tegeder
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Correction
Biochemistry & Molecular Biology
Carine Thalman, Guilherme Horta, Lianyong Qiao, Heiko Endle, Irmgard Tegeder, Hong Cheng, Gregor Laube, Torfi Sigurdsson, Maria Jelena Hauser, Stefan Tenzer, Ute Distler, Junken Aoki, Andrew J. Morris, Gerd Geisslinger, Jochen Roeper, Sergei Kirischuk, Heiko J. Luhmann, Konstantin Radyushkin, Robert Nitsch, Johannes Vogt
MOLECULAR PSYCHIATRY
(2020)
Meeting Abstract
Psychiatry
Johannes Vogt, Carine Thalman, Guilherme Horta, Irmgard Tegeder, Gregor Laube, Konstantin Radyushkin, Robert Nitsch
SCHIZOPHRENIA BULLETIN
(2019)
Article
Immunology
Katja Schmitz, Annett Wilken-Schmitz, Verica Vasic, Robert Brunkhorst, Mirko Schmidt, Irmgard Tegeder
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Irmgard Tegeder, Donat Koegel
Summary: Autophagy is a cellular degradation pathway that prevents accumulation of harmful materials and supports cell survival. Excessive autophagy can lead to cell death, with the integrity of lysosomal membranes playing a crucial role in determining cellular fate.
Article
Biochemistry & Molecular Biology
Regina Hummel, Manuel Lang, Simona Walderbach, Yong Wang, Irmgard Tegeder, Christina Goelz, Michael K. E. Schaefer
Summary: Progranulin is a neurotrophic and anti-inflammatory factor with protective effects in animal models of brain injury. However, the study showed that intracerebroventricular administration of recombinant progranulin did not have the expected protective effects in the acute phase of traumatic brain injury in mice, and even aggravated blood-brain barrier disruption.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lucie Valek, Irmgard Tegeder
Summary: Rodent models of Parkinson's disease are created using transgenic methods like mutant synuclein expression, PD gene deletions, MPTP or rotenone injections, or seeding with synuclein fibrils. These models exhibit histopathologic features of PD, such as Lewi bodies, but do not completely mimic the predominant loss of dopaminergic neurons. A study introducing transgenic diphtheria toxin receptor to mice showed partial ablation of neurons without PD-like behavioral correlates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bao Ngoc Tran, Lucie Valek, Annett Wilken-Schmitz, Dominik Christian Fuhrmann, Dimitry Namgaladze, Ilka Wittig, Irmgard Tegeder
Summary: The study showed that Nucleoredoxin plays a crucial role in neuronal function, impacting neuronal plasticity and synaptic protein activity. Mice deficient in synaptic protein Nestin-NXN-/- displayed normal behavior in tests, but showed reduced interest in rewards.
Article
Biochemistry & Molecular Biology
Nathalie Brunkhorst-Kanaan, Sandra Trautmann, Yannick Schreiber, Dominique Thomas, Sarah Kittel-Schneider, Robert Gurke, Gerd Geisslinger, Andreas Reif, Irmgard Tegeder
Summary: This study found that patients with adult ADHD had increased plasma concentrations of sphingosine-1-phosphate (S1P d18:1), sphinganine-1-phosphate (S1P d18:0), anandamide (AEA), and arachidonoylglycerol, while patients with affective disorders had increased long chain ceramides, particularly Cer22:0, but lower levels of endocannabinoids. Patients with comorbid ADHD and affective disorders displayed intermediate levels of sphingolipids compared to non-comorbid patients. The ratio of S1P d18:1 to Cer22:0 may be a potential diagnostic or prognostic tool.
Article
Nutrition & Dietetics
Lana Schumann, Annett Wilken-Schmitz, Sandra Trautmann, Alexandra Vogel, Yannick Schreiber, Lisa Hahnefeld, Robert Gurke, Gerd Geisslinger, Irmgard Tegeder
Summary: Progranulin deficiency in mice leads to a stronger preference for fatty taste and an increase in body weight, potentially due to reduced CD36 expression in the tongue.
Article
Biochemistry & Molecular Biology
Lisa Hahnefeld, Alexandra Vogel, Robert Gurke, Gerd Geisslinger, Michael K. E. Schaefer, Irmgard Tegeder
Summary: Traumatic brain injury (TBI) often results in long-lasting disabilities such as headache, fatigue, insomnia, hyperactivity, and cognitive deficits. A study conducted in mice found that persistent non-goal-directed hyperactivity is a characteristic behavior after TBI and is associated with low levels of endocannabinoids in the perilesional cortex. In a new analysis, lipidome patterns in the brain and plasma of TBI mice were compared to sham mice, revealing an increase in neutral lipids in the perilesional cortex. This lipid accumulation, along with a reduction in hexosylceramides and phosphatidylethanolamines, may contribute to the behavioral dimensions of post-TBI psychopathology.
Article
Biochemistry & Molecular Biology
Lucie Valek, Bao Ngoc Tran, Irmgard Tegeder
Summary: The study found that nucleoredoxin (NXN) plays an important role in regulating thermal sensation and nociception. The loss of NXN in neurons leads to increased sensitivity to cold temperature and heightened heat nociception in mice. These abnormal responses are associated with changes in calcium influx, mitochondrial dysfunction, and increased density of neurite trees in sensory neurons.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ellen Niederberger, Annett Wilken-Schmitz, Christine Manderscheid, Yannick Schreiber, Robert Gurke, Irmgard Tegeder
Summary: Oral administration of rotenone in mice as a model for Parkinson's disease did not show significant behavioral or biological effects within 8 weeks. Although it caused local gastrointestinal toxicity and weight gain suppression, it failed to replicate the characteristics of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Racz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt
Summary: Hypothalamic AgRP neurons control cortical excitability, hyperphagia, and body weight gain by regulating peripheral and central levels of lysophospholipids in association with food deprivation. Changes in peripheral metabolism affect brain lipid levels and cortical excitability. Lysophosphatidic acid (LPA) species are elevated after fasting and contribute to higher cortical excitability. This effect is mediated by hypothalamic AgRP neurons and plays a role in fasting-induced hyperphagia.
Article
Multidisciplinary Sciences
Juliane Mooz, Kristina Riegel, P. S. Hari, Anguraj Sadanandam, Federico Marini, Matthias Klein, Ulrike Werner, Wilfried Roth, Annett Wilken-Schmitz, Irmgard Tegeder, Krishnaraj Rajalingam
Summary: The expression level of ARAF kinase is decreased in lung cancer and is associated with lymph node metastasis and poor patient survival. Depletion of ARAF promotes anchorage-independent growth and metastasis through activation of AKT signaling in a subset of lung cancer cells. ARAF suppresses ERBB3-AKT signaling and tumor metastasis by inhibiting ERBB3 expression.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)