GpTx-1 and [Ala5 , Phe6 , Leu26 , Arg28 ]GpTx-1, two peptide NaV 1.7 inhibitors: analgesic and tolerance properties at the spinal level

CB 1 cannabinoid receptor agonist mouse VD-hemopressin(α) produced supraspinal analgesic activity in the preclinical models of pain

(2018) Ting Zheng et al.   BRAIN RESEARCH

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

(2018) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy

(2018) Aoibhinn McDonnell et al.   PAIN

Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7

(2018) Sangsu Bang et al.   Neuroscience Bulletin

Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model

(2017) Run Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7

(2017) Zoë V. F. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial

(2017) Joanna M Zakrzewska et al.   LANCET NEUROLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

(2017) Jennifer R. Deuis et al.   Scientific Reports

BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice

(2016) Ning Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities

(2016) Zi-Long Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice

(2016) X.-H. Li et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Upregulation of the sodium channel NaVβ4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation

(2016) Wenrui Xie et al.   PAIN

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

(2016) Jennifer Deuis et al.   Toxins

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

(2016) Aristos J. Alexandrou et al.   PLoS One

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat

(2015) W. Rahman et al.   NEUROSCIENCE

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

(2015) Michael S. Minett et al.   Nature Communications

Intrathecal Injection of the Peptide Myr-NR2B9c Attenuates Bone Cancer Pain Via Perturbing N-Methyl-D-Aspartate Receptor-PSD-95 Protein Interactions in Mice

(2014) Yue Liu et al.   ANESTHESIA AND ANALGESIA

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Action of Phα1β, a Peptide From the Venom of the Spider Phoneutria nigriventer, on the Analgesic and Adverse Effects Caused by Morphine in Mice

(2014) Raquel Tonello et al.   JOURNAL OF PAIN

Analgesic Effects of Huwentoxin-IV on Animal Models of Inflammatory and Neuropathic Pain

(2014) Yu Liu et al.   PROTEIN AND PEPTIDE LETTERS

Opioids, sensory systems and chronic pain

(2013) Christoph Stein   EUROPEAN JOURNAL OF PHARMACOLOGY

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

(2013) K. McCormack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two tarantula venom peptides as potent and differential NaV channels blockers

(2013) Ronit S. Cherki et al.   TOXICON

Neurological perspectives on voltage-gated sodium channels

(2012) N. Eijkelkamp et al.   BRAIN

Increased Expression of Sodium Channel Subunit Nav1.1 in the Injured Dorsal Root Ganglion After Peripheral Nerve Injury

(2011) Wei Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship

(2011) Istvan Macsari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea

(2011) Seigo Ono et al.   TOXICON

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain

(2008) Maria Osikowicz et al.   PAIN