Protein Kinase C regulation of ion channels: the involvement of PIP2

PIP2 regulation of TRPC5 channel activation and desensitization

(2021) Mehek Ningoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of human Cav2.2 channel blocked by the painkiller ziconotide

(2021) Shuai Gao et al.   NATURE

PIP2 Mediated Inhibition of TREK Potassium Currents by Bradykinin in Mouse Sympathetic Neurons

(2020) Paula Rivas-Ramírez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC

(2020) Crystal R. Archer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

(2020) Mircea Iftinca et al.   Molecular Brain

Obligatory role for PKCδ in PIP 2 ‐mediated activation of store‐operated TRPC1 channels in vascular smooth muscle cells

(2020) Miguel A. S. Martín‐Aragón Baudel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway

(2020) Ling Zhang et al.   MOLECULAR NEUROBIOLOGY

PKCα promotes insulin secretion via TRPC1 phosphorylation in INS-1E cells

(2019) Jing Xu et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Differential Regulation of Human Ether-à-Go-Go–Related Gene (hERG) Current and Expression by Activation of Protein Kinase C

(2019) Morgan E. Sutherland-Deveen et al.   MOLECULAR PHARMACOLOGY

The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel

(2019) Dian Ding et al.   Cell Reports

Phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl- channel TMEM16A

(2019) Maiwase Tembo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl− channel ANO1 (TMEM16A)

(2019) Kuai Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular pH and intracellular phosphatidylinositol 4,5-bisphosphate control Cl− currents in guinea pig detrusor smooth muscle cells

(2019) Viktor Yarotskyy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PKCβII specifically regulates KCNQ1/KCNE1 channel membrane localization

(2019) Chen Braun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphorylation of TRPV1 S801 Contributes to Modality-Specific Hyperalgesia in Mice

(2019) John Joseph et al.   JOURNAL OF NEUROSCIENCE

Protein kinase C as a tumor suppressor

(2018) Alexandra C. Newton   SEMINARS IN CANCER BIOLOGY

Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate

(2018) Mayra Delgado-Ramírez et al.   Scientific Reports

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

(2018) Wang Zheng et al.   Cell Reports

Two‐pore domain potassium channels: emerging targets for novel analgesic drugs: IUPHAR Review 26

(2018) Kirin Gada et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protein kinase C and cardiac dysfunction: a review

(2017) Raphael M. Singh et al.   HEART FAILURE REVIEWS

Molecular structure of human KATP in complex with ATP and ADP

(2017) Kenneth Pak Kin Lee et al.   eLife

Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

(2016) Daniel Scherer et al.   PLoS One

Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol

(2016) Ursula Storch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels

(2015) Diomedes E. Logothetis et al.   Annual Review of Physiology

PKC and AMPK regulation of Kv1.5 potassium channels

(2015) Martin Nybo Andersen et al.   Channels

Small-conductance Ca2+-activated K+ channels and cardiac arrhythmias

(2015) Xiao-Dong Zhang et al.   HEART RHYTHM

Two distinct effects of PIP2underlie auxiliary subunit-dependent modulation of Slo1 BK channels

(2015) Yutao Tian et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels

(2015) S. K. Adney et al.   JOURNAL OF NEUROSCIENCE

Phosphoinositide regulation of TRPV1 revisited

(2015) Tibor Rohacs   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes

(2015) Dongrui Ma et al.   Stem Cell Research & Therapy

Differential Regulation of Proton-Sensitive Ion Channels by Phospholipids: A Comparative Study between ASICs and TRPV1

(2015) Hae-Jin Kweon et al.   PLoS One

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker

(2014) Zhi-Yong Tan et al.   FEBS LETTERS

Phosphorylation mediated structural and functional changes in pentameric ligand-gated ion channels: Implications for drug discovery

(2014) Sahil Talwar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Regulation of BK Channel Activity through the RCK1 Ca2+Coordination Site

(2014) Qiong-Yao Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective phosphorylation modulates the PIP2 sensitivity of the CaM–SK channel complex

(2014) Miao Zhang et al.   Nature Chemical Biology

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

The CFTR Ion Channel: Gating, Regulation, and Anion Permeation

(2013) T.-C. Hwang et al.   Cold Spring Harbor Perspectives in Medicine

Membrane potential and cancer progression

(2013) Ming Yang et al.   Frontiers in Physiology

Mechanosensitive Cl− secretion in biliary epithelium mediated through TMEM16A

(2012) Amal K. Dutta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation

(2012) Anastasia Kosenko et al.   EMBO JOURNAL

Mass Spectrometry-Based Identification of Native Cardiac Nav1.5 Channel α Subunit Phosphorylation Sites

(2012) Céline Marionneau et al.   JOURNAL OF PROTEOME RESEARCH

Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

(2012) Aldo A. Rodríguez-Menchaca et al.   Frontiers in Pharmacology

Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels

(2011) Haifa Hallaq et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

(2011) John P. Adelman et al.   Annual Review of Physiology

Direct effect of protein kinase C inhibitors on cardiovascular ion channels

(2011) Youn-Kyoung Son et al.   BMB Reports

PKC-dependent activation of human K2P18.1 K+ channels

(2011) Ann-Kathrin Rahm et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Differential Protein Kinase C Isoform Regulation and Increased Constitutive Activity of Acetylcholine-Regulated Potassium Channels in Atrial Remodeling

(2011) Samy Makary et al.   CIRCULATION RESEARCH

Regulation of the ATP-sensitive Potassium Channel Subunit, Kir6.2, by a Ca2+-dependent Protein Kinase C

(2011) Qadeer Aziz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central role of PKCα in isoenzyme-selective regulation of cardiac transient outward current Ito and Kv4.3 channels

(2011) E.P. Scholz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protein kinase C mediated pH i -regulation of ROMK1 channels via a phosphatidylinositol-4,5-bisphosphate-dependent mechanism

(2011) Po-Tsang Huang et al.   JOURNAL OF MOLECULAR MODELING

Relief of Mg2+-Dependent Inhibition of TRPM1 by PKC  at the Rod Bipolar Cell Synapse

(2011) M. A. F. Rampino et al.   JOURNAL OF NEUROSCIENCE

Neuropathic Nav1.3-Mediated Sensitization to P2X Activation is Regulated by Protein Kinase C

(2011) Gary Mo et al.   Molecular Pain

The substrates and binding partners of protein kinase Cε

(2010) Philip M. Newton et al.   BIOCHEMICAL JOURNAL

PKA and PKC partially rescue Long QT type 1 phenotype by restoring channel-PIP2interactions

(2010) Alessandra Matavel et al.   Channels

Protein Kinase C-dependent Phosphorylation of Transient Receptor Potential Canonical 6 (TRPC6) on Serine 448 Causes Channel Inhibition

(2010) Simon M. Bousquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of single-channel properties of TRPV1 by phosphorylation

(2010) Milena Studer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of sodium channel activity by phosphorylation

(2010) Todd Scheuer   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A

(2009) Carmen R. Valdivia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle

(2009) William A. Large et al.   CELL CALCIUM

Activation of the TRPV4 Ion Channel Is Enhanced by Phosphorylation

(2009) Hueng-Chuen Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKC∊-Dependent Potentiation of TTX-Resistant NaV1.8 Current by Neurokinin-1 Receptor Activation in Rat Dorsal Root Ganglion Neurons

(2009) Chun-Lei Cang et al.   Molecular Pain

Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function

(2008) Edlira Bashari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Dual regulation of renal Kir7.1 potassium channels by protein Kinase A and protein Kinase C

(2008) Wei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Kv4.2 is a locus for PKC and ERK/MAPK cross-talk

(2008) Laura A. Schrader et al.   BIOCHEMICAL JOURNAL

Physiologic regulation of the epithelial sodium channel by phosphatidylinositides

(2008) Oleh Pochynyuk et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Direct Regulation of BK Channels by Phosphatidylinositol 4,5-Bisphosphate as a Novel Signaling Pathway

(2008) Thirumalini Vaithianathan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Functional properties and differential neuromodulation of Nav1.6 channels

(2008) Yuan Chen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting

(2007) Dietlinde Wolf et al.   VIROLOGY