PIP2 regulation of TRPC5 channel activation and desensitization

The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents

(2020) Yu Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels

(2020) Leigh D. Plant et al.   Cell Reports

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

(2019) Swagat Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

(2019) Jingjing Duan et al.   Science Advances

On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer

(2019) Dailin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

(2017) Yiming Zhou et al.   SCIENCE

Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+Potentiation, and Ca2+Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel

(2016) Xingjuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol

(2016) Ursula Storch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels

(2015) Diomedes E. Logothetis et al.   Annual Review of Physiology

PLC-mediated PI(4,5)P2hydrolysis regulates activation and inactivation of TRPC6/7 channels

(2014) Kyohei Itsuki et al.   JOURNAL OF GENERAL PHYSIOLOGY

Design and construction of a multiwavelength, micromirror total internal reflectance fluorescence microscope

(2014) Joshua Larson et al.   Nature Protocols

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Optogenetic control of phosphoinositide metabolism

(2012) O. Idevall-Hagren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

(2011) Brady K Atwood et al.   BMC GENOMICS

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Phosphatidylinositol 4,5-Bisphosphate Activates Slo3 Currents and Its Hydrolysis Underlies the Epidermal Growth Factor-induced Current Inhibition

(2010) Qiong-Yao Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Phosphatidylinositol 4,5-Bisphosphate in the Desensitization of Canonical Transient Receptor Potential 5

(2008) Byung Joo Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels

(2008) Mohamed Trebak et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY