Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

The emergence of transcriptional identity in somatosensory neurons

(2020) Nikhil Sharma et al.   NATURE

Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation

(2019) Luyu Liu et al.   JOURNAL OF NEUROSCIENCE

TRPV1 promotes opioid analgesia during inflammation

(2019) Lilian Basso et al.   Science Signaling

Tetrodotoxin-sensitive sodium channels mediate action potential firing and excitability in menthol-sensitive Vglut3-lineage sensory neurons

(2019) Theanne N. Griffith et al.   JOURNAL OF NEUROSCIENCE

Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation

(2019) Xuming Zhang   Cell Reports

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

(2018) Miriam Stoeber et al.   NEURON

Inflammation Induces Epac Protein Kinase Alpha and Epsilon Signaling in TRPV1-Mediated Hyperalgesia

(2018) Yanping Gu et al.   PAIN

Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis

(2018) Rosa Señarís et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats

(2018) Viacheslav Viatchenko-Karpinski et al.   Molecular Brain

Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada

(2018) Tara Gomes et al.   BMJ-British Medical Journal

μ-Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid-induced hyperalgesia

(2018) Jie Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sustained Morphine Administration Induces TRPM8-Dependent Cold Hyperalgesia

(2017) Kerui Gong et al.   JOURNAL OF PAIN

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

(2017) Gregory Corder et al.   NATURE MEDICINE

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Cellular and Molecular Targets of Menthol Actions

(2017) Murat Oz et al.   Frontiers in Pharmacology

Opioid Receptors

(2016) Christoph Stein   Annual Review of Medicine

Opioid-induced hyperalgesia: Cellular and molecular mechanisms

(2016) Laurie-Anne Roeckel et al.   NEUROSCIENCE

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

(2016) Michelle L. Halls et al.   Science Signaling

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

(2016) Michelle L. Halls et al.   Science Signaling

Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel

(2015) Gabriel Bidaux et al.   BIOPHYSICAL JOURNAL

TRPM8 is a neuronal osmosensor that regulates eye blinking in mice

(2015) Talisia Quallo et al.   Nature Communications

The Region Adjacent to the C-end of the Inner Gate in Transient Receptor Potential Melastatin 8 (TRPM8) Channels Plays a Central Role in Allosteric Channel Activation

(2014) Francisco José Taberner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temperature and Voltage Coupling to Channel Opening in Transient Receptor Potential Melastatin 8 (TRPM8)

(2014) Natalia Raddatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Regionally selective activation of ERK and JNK in morphine paradoxical hyperalgesia: A step toward improving opioid pain therapy

(2014) Maria Domenica Sanna et al.   NEUROPHARMACOLOGY

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

(2014) Cruz Morenilla-Palao et al.   Cell Reports

Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8

(2013) George Shapovalov et al.   Cell Reports

Molecular Mechanisms of Opioid Receptor-dependent Signaling and Behavior

(2011) Ream Al-Hasani et al.   ANESTHESIOLOGY

Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain

(2011) Lin Su et al.   BMC NEUROSCIENCE

TRPM8 acute desensitization is mediated by calmodulin and requires PIP2: distinction from tachyphylaxis

(2011) Ignacio Sarria et al.   JOURNAL OF NEUROPHYSIOLOGY

Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels

(2011) Yevgen Yudin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine

(2011) Carl Goodman   Molecular Medicine Reports

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice

(2010) Masahiro Ohsawa et al.   PAIN

Cognitive–Affective and Somatic Side Effects of Morphine and Pentazocine: Side-Effect Profiles in Healthy Adults

(2009) Joseph L. Riley et al.   PAIN MEDICINE

Activity of the Neuronal Cold Sensor TRPM8 Is Regulated by Phospholipase C via the Phospholipid Phosphoinositol 4,5-Bisphosphate

(2008) Richard L. Daniels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections

(2008) A. Dhaka et al.   JOURNAL OF NEUROSCIENCE