Two distinct effects of PIP2underlie auxiliary subunit-dependent modulation of Slo1 BK channels

Positions of the cytoplasmic end of BK α S0 helix relative to S1–S6 and of β1 TM1 and TM2 relative to S0–S6

(2015) Guoxia Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Counterion-mediated cluster formation by polyphosphoinositides

(2014) Yu-Hsiu Wang et al.   CHEMISTRY AND PHYSICS OF LIPIDS

LRRC26 Is a Functional BK Channel Auxiliary γ Subunit in Arterial Smooth Muscle Cells

(2014) Kirk W. Evanson et al.   CIRCULATION RESEARCH

Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Regulation of BK Channel Activity through the RCK1 Ca2+Coordination Site

(2014) Qiong-Yao Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidic acid modulation of Kv channel voltage sensor function

(2014) Richard K Hite et al.   eLife

Lipid regulation of BK channel function

(2014) Alex M. Dopico et al.   Frontiers in Physiology

Quantum and All-Atom Molecular Dynamics Simulations of Protonation and Divalent Ion Binding to Phosphatidylinositol 4,5-Bisphosphate (PIP2)

(2013) David R. Slochower et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Transduction of Voltage and Ca2+ Signals by Slo1 BK Channels

(2013) T. Hoshi et al.   PHYSIOLOGY

Properties of Slo1 K+ channels with and without the gating ring

(2013) G. Budelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BK channel opening involves side-chain reorientation of multiple deep-pore residues

(2013) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2+-dependent K+ channels

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2)

(2013) Panpan Hou et al.   Scientific Reports

The first transmembrane domain (TM1) of β2-subunit binds to the transmembrane domain S1 of α-subunit in BK potassium channels

(2012) Francisco J. Morera et al.   FEBS LETTERS

Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel

(2012) Roland S. Wu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular mechanism of pharmacological activation of BK channels

(2012) G. Gessner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BK potassium channel modulation by leucine-rich repeat-containing proteins

(2012) J. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism Underlying Phosphatidylinositol 4,5-Bisphosphate-induced Inhibition of SpIH Channels

(2011) Galen E. Flynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel

(2011) C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Location of modulatory β subunits in BK potassium channels

(2010) Guoxia Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium

(2010) Jiusheng Yan et al.   NATURE

Ion sensing in the RCK1 domain of BK channels

(2010) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Location of the  4 Transmembrane Helices in the BK Potassium Channel

(2009) R. S. Wu et al.   JOURNAL OF NEUROSCIENCE

Modulation of BKCa Channel Gating by Endogenous Signaling Molecules

(2009) Shangwei Hou et al.   PHYSIOLOGY

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Proteins and cholesterol-rich domains

(2008) Richard M. Epand   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

PIP2PIP2Hooray for Maxi K+

(2008) Ann R. Rittenhouse   JOURNAL OF GENERAL PHYSIOLOGY

Direct Regulation of BK Channels by Phosphatidylinositol 4,5-Bisphosphate as a Novel Signaling Pathway

(2008) Thirumalini Vaithianathan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels

(2008) Yanping Xu et al.   NATURE