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Title
Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 7, Pages 3784
Publisher
MDPI AG
Online
2022-03-30
DOI
10.3390/ijms23073784
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Note: Only part of the references are listed.- Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours
- (2022) Florian J Groelly et al. EMBO Molecular Medicine
- Telomeres: history, health, and hallmarks of aging
- (2021) Deepavali Chakravarti et al. CELL
- Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
- (2021) Nighat Noureen et al. Nature Communications
- Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
- (2021) Ci Ji Lim et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis
- (2021) Raúl Sánchez-Vázquez et al. PLoS Genetics
- Transcriptional regulation of telomeric repeat-containing RNA by acridine derivatives
- (2021) Shuangshuang Kang et al. RNA Biology
- p53 and Tumor Suppression: It Takes a Network
- (2021) Anthony M. Boutelle et al. TRENDS IN CELL BIOLOGY
- G-quadruplex DNA: a novel target for drug design
- (2021) Fang-Yuan Teng et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A Novel Screen for Expression Regulators of the Telomeric Protein TRF2 Identified Small Molecules That Impair TRF2 Dependent Immunosuppression and Tumor Growth
- (2021) Mounir El Maï et al. Cancers
- Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound
- (2021) Simona Marzano et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Non‐coding TERRA inhibits the progression of hepatocellular carcinoma via regulating telomerase‐mediated telomere length
- (2020) Haiyan Cao et al. CANCER SCIENCE
- Telomeric Chromatin and TERRA
- (2020) Amandine Barral et al. JOURNAL OF MOLECULAR BIOLOGY
- Regulation of human telomerase in homeostasis and disease
- (2020) Caitlin M. Roake et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Human POT1 unfolds G-quadruplexes by conformational selection
- (2020) Jonathan B Chaires et al. NUCLEIC ACIDS RESEARCH
- The human telomeric nucleosome displays distinct structural and dynamic properties
- (2020) Aghil Soman et al. NUCLEIC ACIDS RESEARCH
- Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability
- (2020) Kez Cleal et al. TRENDS IN GENETICS
- MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence
- (2020) Tingting Li et al. Aging-US
- Twenty years of t-loops: A case study for the importance of collaboration in molecular biology
- (2020) Ľubomír Tomáška et al. DNA REPAIR
- Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential
- (2020) Stina George Fernandes et al. Cancers
- Determinants of telomere length across human tissues
- (2020) Kathryn Demanelis et al. SCIENCE
- Role of POT1 in Human Cancer
- (2020) Yangxiu Wu et al. Cancers
- The end protection problem—an unexpected twist in the tail
- (2020) Phil Ruis et al. GENES & DEVELOPMENT
- Human Endometrial Carcinogenesis Is Associated with Significant Reduction in Long Non-Coding RNA, TERRA
- (2020) Meera Adishesh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Emerging roles of telomeric chromatin alterations in cancer
- (2019) Stefano Cacchione et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability
- (2019) Nicole Bettin et al. Cells
- TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
- (2019) Pasquale Zizza et al. NUCLEIC ACIDS RESEARCH
- Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2
- (2019) Julien Cherfils‐Vicini et al. EMBO JOURNAL
- Multiple cancer pathways regulate telomere protection
- (2019) Leire Bejarano et al. EMBO Molecular Medicine
- G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells
- (2019) F. Berardinelli et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Structural biology of telomeres and telomerase
- (2019) Eric M. Smith et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Virtual high-throughput screening of natural compounds in-search of potential inhibitors for protection of telomeres 1 (POT1)
- (2019) Mohd Amir et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle
- (2019) Grzegorz Sarek et al. NATURE
- Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
- (2019) Julio Aguado et al. Nature Communications
- Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation
- (2018) Bing Shu et al. CHEMICAL COMMUNICATIONS
- Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors
- (2018) Satarupa Sengupta et al. MOLECULAR CANCER THERAPEUTICS
- Synergy of Immune Checkpoint Blockade with a Novel Synthetic Consensus DNA Vaccine Targeting TERT
- (2018) Elizabeth K. Duperret et al. MOLECULAR THERAPY
- Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma
- (2018) Patricia Reyes-Uribe et al. ONCOGENE
- Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction
- (2018) Xia Chen et al. ACS Medicinal Chemistry Letters
- Administration of a Nucleoside Analog Promotes Cancer Cell Death in a Telomerase-Dependent Manner
- (2018) Xuehuo Zeng et al. Cell Reports
- Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells
- (2018) Daniela Muoio et al. FEBS Journal
- Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds
- (2018) Alessia Pagano et al. Frontiers in Chemistry
- Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
- (2017) Luca Pompili et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- TERTbiology and function in cancer: beyond immortalisation
- (2017) Ana Pestana et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA
- (2017) Marianna Feretzaki et al. METHODS
- Targeting telomerase and telomeres to enhance ionizing radiation effects in in vitro and in vivo cancer models
- (2017) F. Berardinelli et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
- (2017) Flavia Michelini et al. NATURE CELL BIOLOGY
- Systematic analysis of telomere length and somatic alterations in 31 cancer types
- (2017) Floris P Barthel et al. NATURE GENETICS
- Modulation of telomere protection by the PI3K/AKT pathway
- (2017) Marinela Méndez-Pertuz et al. Nature Communications
- CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
- (2017) Hong Xu et al. Nature Communications
- DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
- (2017) Francesca Rossiello et al. Nature Communications
- Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres
- (2017) Rebecca A. Dagg et al. Cell Reports
- Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis
- (2017) Rosa M. Marión et al. Stem Cell Reports
- Telomeres and Cell Senescence - Size Matters Not
- (2017) Stella Victorelli et al. EBioMedicine
- G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells
- (2016) Daiki Hasegawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2016) Jutta Zimmer et al. MOLECULAR CELL
- A second chance for telomerase reverse transcriptase in anticancer immunotherapy
- (2016) Maurizio Zanetti Nature Reviews Clinical Oncology
- Transcription of telomeric DNA leads to high levels of homologous recombination and t-loops
- (2016) Anirban Kar et al. NUCLEIC ACIDS RESEARCH
- SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage
- (2016) Angela Rizzo et al. NUCLEIC ACIDS RESEARCH
- Role of Telomeres and Telomerase in Aging and Cancer
- (2016) J. W. Shay Cancer Discovery
- ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2
- (2016) Vincent Picco et al. Oncotarget
- Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction
- (2016) Ye Cheng et al. Oncotarget
- Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression
- (2015) Zhenhua Luo et al. AGING CELL
- Identification of novel interactors of human telomeric G-quadruplex DNA
- (2015) Bruno Pagano et al. CHEMICAL COMMUNICATIONS
- Looking for Efficient G-Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug-Like Molecules
- (2015) Bruno Pagano et al. ChemMedChem
- The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells
- (2015) F. Berardinelli et al. DNA REPAIR
- Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage
- (2015) M. Garcia-Beccaria et al. EMBO Molecular Medicine
- A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis
- (2015) Ayalew Tefferi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treating Myeloproliferation — On Target or Off?
- (2015) Mary Armanios et al. NEW ENGLAND JOURNAL OF MEDICINE
- A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds
- (2015) Erica Salvati et al. NUCLEIC ACIDS RESEARCH
- Telomeric G-quadruplexes are a substrate and site of localization for human telomerase
- (2015) Aaron L. Moye et al. Nature Communications
- Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity
- (2015) Emilio Cusanelli et al. Frontiers in Genetics
- Human dyskerin: beyond telomeres
- (2014) Alberto Angrisani et al. BIOLOGICAL CHEMISTRY
- miR-155 Drives Telomere Fragility in Human Breast Cancer by Targeting TRF1
- (2014) R. Dinami et al. CANCER RESEARCH
- Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing
- (2014) Francesca Rossiello et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Shading the TRF2 Recruiting Function: A New Horizon in Drug Development
- (2014) Salvatore Di Maro et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- In the End, What’s the Problem?
- (2014) Raymund J. Wellinger MOLECULAR CELL
- The Telomeric Protein TRF2 Regulates Angiogenesis by Binding and Activating the PDGFRβ Promoter
- (2014) Mounir El Maï et al. Cell Reports
- Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
- (2013) Irmina Diala et al. EMBO REPORTS
- TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells
- (2013) Annamaria Biroccio et al. NATURE CELL BIOLOGY
- A Small Molecule Inhibitor of Pot1 Binding to Telomeric DNA
- (2012) Sarah E. Altschuler et al. BIOCHEMISTRY
- Aromatic Core Extension in the Series of N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands: Increased Telomere Damage, Antitumor Activity, and Strong Selectivity for Neoplastic over Healthy Cells
- (2012) Marco Franceschin et al. ChemMedChem
- Telomere structure and telomerase in health and disease
- (2012) DANIEL E. GOMEZ et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres
- (2012) Yan Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2
- (2012) Giulia Biffi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure, function and targeting of human telomere RNA
- (2012) Yan Xu et al. METHODS
- Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
- (2012) Sebastian Müller et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Removal of Shelterin Reveals the Telomere End-Protection Problem
- (2012) A. Sfeir et al. SCIENCE
- Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomas
- (2012) Kimberly S. Butler et al. Cancer Medicine
- Telomerase: Structure, functions, and activity regulation
- (2011) M. I. Zvereva et al. BIOCHEMISTRY-MOSCOW
- Dyskeratosis congenita and the DNA damage response
- (2011) Michael Kirwan et al. BRITISH JOURNAL OF HAEMATOLOGY
- N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands Have Selective Antiproliferative Effects on Cancer Cells and Induce Telomere Damage
- (2011) Valentina Casagrande et al. JOURNAL OF MEDICINAL CHEMISTRY
- It all comes together at the ends: Telomerase structure, function, and biogenesis
- (2011) Joshua D. Podlevsky et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Genetic variants in telomere-maintaining genes and skin cancer risk
- (2010) Hongmei Nan et al. HUMAN GENETICS
- PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy
- (2010) E Salvati et al. ONCOGENE
- G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo
- (2009) Mekala Gunaratnam et al. BIOCHEMICAL PHARMACOLOGY
- BRACO19 analog dimers with improved inhibition of telomerase and hPot 1
- (2009) Yuan-Te Fu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Human telomeric G-quadruplex: structures of DNA and RNA sequences
- (2009) Anh Tuân Phan FEBS Journal
- G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors
- (2008) C. Leonetti et al. CLINICAL CANCER RESEARCH
- G-Quadruplex Formation by Human Telomeric Repeats-Containing RNA in Na+Solution
- (2008) Yan Xu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Telomeres and Aging
- (2008) Geraldine Aubert et al. PHYSIOLOGICAL REVIEWS
- Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities
- (2004) Shingo Hanaoka et al. PROTEIN SCIENCE
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