The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability

CTCF sites display cell cycle–dependent dynamics in factor binding and nucleosome positioning

(2019) Marlies E. Oomen et al.   GENOME RESEARCH

Involvement of CTCF in transcription regulation of EGR1 at early G1 phase as an architecture factor

(2019) Takeshi Sekiya et al.   Scientific Reports

Induction and relocalization of telomeric repeat-containing RNAs during diauxic shift in budding yeast

(2018) Carmina Angelica Perez-Romero et al.   CURRENT GENETICS

Impact of oxidative stress on telomere biology

(2018) Wareed Ahmed et al.   DIFFERENTIATION

DNA:RNA hybrids at telomeres - when it is better to be out of the (R) loop

(2018) Shir Toubiana et al.   FEBS Journal

Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

(2018) Christopher Grunseich et al.   MOLECULAR CELL

Epigenetic features of human telomeres

(2018) María D Cubiles et al.   NUCLEIC ACIDS RESEARCH

Live-cell imaging reveals the dynamics and function of single-telomere TERRA molecules in cancer cells

(2018) Laura Avogaro et al.   RNA Biology

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

(2018) Juan J. Montero et al.   Nature Communications

Chromatin conformation regulates the coordination between DNA replication and transcription

(2018) Ricardo Almeida et al.   Nature Communications

Plastic roles of phenylalanine and tyrosine residues of TLS/FUS in complex formation with the G-quadruplexes of telomeric DNA and TERRA

(2018) Keiko Kondo et al.   Scientific Reports

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Preserving replication fork integrity and competence via the homologous recombination pathway

(2018) Anissia Ait Saada et al.   DNA REPAIR

Genomic origin and nuclear localization of TERRA telomeric repeat-containing RNA: from Darkness to Dawn

(2017) Aurélie Diman et al.   FEBS Journal

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA

(2017) Marianna Feretzaki et al.   METHODS

Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines

(2017) Xueyin Wang et al.   MOLECULAR CELL

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PAR-TERRA directs homologous sex chromosome pairing

(2017) Hsueh-Ping Chu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heat shock factor 1 promotes TERRA transcription and telomere protection upon heat stress

(2017) Sivan Koskas et al.   NUCLEIC ACIDS RESEARCH

Snail1 transcription factor controls telomere transcription and integrity

(2017) Rocco Mazzolini et al.   NUCLEIC ACIDS RESEARCH

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge

(2017) Alexander P. Sobinoff et al.   TRENDS IN GENETICS

CTCF driven TERRA transcription facilitates completion of telomere DNA replication

(2017) Kate Beishline et al.   Nature Communications

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

(2017) Shira Sagie et al.   Nature Communications

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

(2017) Francesca Rossiello et al.   Nature Communications

PAR-TERRA directs homologous sex chromosome pairing

(2017) Hsueh-Ping Chu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solving the Telomere Replication Problem

(2017) Laetitia Maestroni et al.   Genes

Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology

(2017) et al.   Genes

The Rb1 tumour suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression

(2017) I. Gonzalez-Vasconcellos et al.   Scientific Reports

CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation

(2016) Matthias Merkenschlager et al.   Annual Review of Genomics and Human Genetics

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(2016) Corina Ohle et al.   CELL

TERRA promotes telomerase‐mediated telomere elongation inSchizosaccharomyces pombe

(2016) Martin Moravec et al.   EMBO REPORTS

Replicating Large Genomes: Divide and Conquer

(2016) Juan Carlos Rivera-Mulia et al.   MOLECULAR CELL

G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme

(2016) Alexander Hirschi et al.   RNA

Telomeric RNAs are essential to maintain telomeres

(2016) Juan José Montero et al.   Nature Communications

Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription

(2016) A. Diman et al.   Science Advances

Spatiotemporal analysis with a genetically encoded fluorescent RNA probe reveals TERRA function around telomeres

(2016) Toshimichi Yamada et al.   Scientific Reports

Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres

(2015) S. Tutton et al.   EMBO JOURNAL

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

(2015) Grzegorz Sarek et al.   MOLECULAR CELL

Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA

(2015) Julien Gros et al.   MOLECULAR CELL

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Rap1 modulates TRF2 attraction to telomeric DNA

(2015) Eliška Janoušková et al.   NUCLEIC ACIDS RESEARCH

Telomere functions grounding on TERRA firma

(2015) Claus M. Azzalin et al.   TRENDS IN CELL BIOLOGY

Telomeric G-quadruplexes are a substrate and site of localization for human telomerase

(2015) Aaron L. Moye et al.   Nature Communications

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

R-loops and initiation of DNA replication in human cells: a missing link?

(2015) Rodrigo Lombraña et al.   Frontiers in Genetics

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity

(2015) Emilio Cusanelli et al.   Frontiers in Genetics

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

(2014) Harikleia Episkopou et al.   NUCLEIC ACIDS RESEARCH

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase

(2014) Tai-Yuan Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The differential processing of telomeres in response to increased telomeric transcription and RNA–DNA hybrid accumulation

(2014) Bettina Balk et al.   RNA Biology

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes

(2014) Isabel López de Silanes et al.   Nature Communications

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

(2014) Antonio Porro et al.   Cell Reports

Telomeric noncoding RNA: telomeric repeat-containing RNA in telomere biology

(2014) Emilio Cusanelli et al.   Wiley Interdisciplinary Reviews-RNA

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS

(2013) Kentaro Takahama et al.   CHEMISTRY & BIOLOGY

The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres

(2013) Anna Postepska-Igielska et al.   EMBO REPORTS

Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

(2013) M. Scheibe et al.   GENOME RESEARCH

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres

(2013) Emilio Cusanelli et al.   MOLECULAR CELL

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

Cell-cycle regulated transcription associates with DNA replication timing in yeast and human

(2013) Hunter B Fraser   GENOME BIOLOGY

Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblasts

(2013) Shiran Yehezkel et al.   Frontiers in Oncology

Telomeric RNA Expression: Length Matters

(2013) Amandine Van Beneden et al.   Frontiers in Oncology

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection

(2012) Zhong Deng et al.   EMBO JOURNAL

Immunofluorescence protects RNA signals in simultaneous RNA–DNA FISH

(2012) Lan-Tian Lai et al.   EXPERIMENTAL CELL RESEARCH

The telomeric transcriptome: From fission yeast to mammals

(2012) Amadou Bah et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere

(2012) N. Özlem Arat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma

(2012) Z. Deng et al.   JOURNAL OF CELL SCIENCE

An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2

(2012) Giulia Biffi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

(2012) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomerase Efficiently Elongates Highly Transcribing Telomeres in Human Cancer Cells

(2012) Benjamin O. Farnung et al.   PLoS One

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends

(2012) Verena Pfeiffer et al.   PLoS Genetics

Telomeres: The silence is broken

(2011) Claus M. Azzalin et al.   CELL CYCLE

TERRA, CpG methylation, and telomere heterochromatin: Lessons from ICF syndrome cells

(2011) Zhong Deng et al.   CELL CYCLE

The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats

(2011) Thomas Simonet et al.   CELL RESEARCH

Human telomeric proteins occupy selective interstitial sites

(2011) Dong Yang et al.   CELL RESEARCH

Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication

(2011) Raghav Chawla et al.   EMBO JOURNAL

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA

(2011) Rachel Litman Flynn et al.   NATURE

Non-coding telomeric and subtelomeric transcripts are differentially regulated by telomeric and heterochromatin assembly factors in fission yeast

(2011) Jessica Greenwood et al.   NUCLEIC ACIDS RESEARCH

The telomeric transcriptome of Schizosaccharomyces pombe

(2011) Amadou Bah et al.   NUCLEIC ACIDS RESEARCH

Telomeric Strategies: Means to an End

(2010) Devanshi Jain et al.   Annual Review of Genetics

On the organization of the nucleosomes associated with telomeric sequences

(2010) Francisco M. Gámez-Arjona et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Telomeres: Structures in need of unwinding

(2010) Katrin Paeschke et al.   FEBS LETTERS

Molecular Dissection of Telomeric Repeat-Containing RNA Biogenesis Unveils the Presence of Distinct and Multiple Regulatory Pathways

(2010) A. Porro et al.   MOLECULAR AND CELLULAR BIOLOGY

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

(2010) E. Abreu et al.   MOLECULAR AND CELLULAR BIOLOGY

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

(2010) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

Telomeric repeat-containing RNA structure in living cells

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERRA transcripts are bound by a complex array of RNA-binding proteins

(2010) Isabel López de Silanes et al.   Nature Communications

Replication Timing of Human Telomeres Is Chromosome Arm–Specific, Influenced by Subtelomeric Structures and Connected to Nuclear Localization

(2010) Nausica Arnoult et al.   PLoS Genetics

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Telomeric RNAs Mark Sex Chromosomes in Stem Cells

(2009) L.-F. Zhang et al.   GENETICS

Structure of Long Telomeric RNA Transcripts

(2009) Adrian Randall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

(2009) Laura J. Ng et al.   NUCLEIC ACIDS RESEARCH

CpG-island promoters drive transcription of human telomeres

(2009) S. G. Nergadze et al.   RNA

Chromatin regulation and non-coding RNAs at mammalian telomeres

(2009) Stefan Schoeftner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions

(2008) Shiran Yehezkel et al.   HUMAN MOLECULAR GENETICS

The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae

(2008) Brian Luke et al.   MOLECULAR CELL

The cohesin ring concatenates sister DNA molecules

(2008) Christian H. Haering et al.   NATURE