FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms

Unraveling the Developmental Roadmap toward Human Brown Adipose Tissue

(2021) Stefania Carobbio et al.   Stem Cell Reports

Application of Animal Models in Cancer Research: Recent Progress and Future Prospects

(2021) Zhitao Li et al.   Cancer Management and Research

RNA demethylation increases the yield and biomass of rice and potato plants in field trials

(2021) Qiong Yu et al.   NATURE BIOTECHNOLOGY

Dual effects of N6-methyladenosine on cancer progression and immunotherapy

(2021) Hui Li et al.   Molecular Therapy-Nucleic Acids

m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling

(2021) Juan Zeng et al.   Molecular Therapy-Nucleic Acids

The Anti-VEGF(R) Drug Discovery Legacy: Improving Attrition Rates by Breaking the Vicious Cycle of Angiogenesis in Cancer

(2021) Domenico Ribatti et al.   Cancers

m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation

(2021) Ruifan Wu et al.   EMBO REPORTS

The Phytochemical Rhein Mediates M6A-Independent Suppression of Adipocyte Differentiation

(2021) Linyuan Huang et al.   Frontiers in Nutrition

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

(2020) Min Han et al.   Frontiers in Neuroscience

Human Pluripotent Stem Cells: A Relevant Model to Identify Pathways Governing Thermogenic Adipocyte Generation

(2020) Xi Yao et al.   Frontiers in Endocrinology

Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates

(2020) Sarah El Hajj Chehadeh et al.   GENE

FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling

(2020) Hao Huang et al.   CANCER RESEARCH

NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity

(2020) Lina Wang et al.   Nature Chemical Biology

The epitranscriptome landscape of small noncoding RNAs in stem cells

(2020) James M. W. R. McElhinney et al.   STEM CELLS

New Twists in Detecting mRNA Modification Dynamics

(2020) Ina Anreiter et al.   TRENDS IN BIOTECHNOLOGY

RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells

(2020) Nobuhiro Tsuruta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy

(2020) Lin Zhao et al.   PATHOLOGY RESEARCH AND PRACTICE

FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signaling pathway

(2020) Lin zhang et al.   RNA Biology

Modeling Adipogenesis: Current and Future Perspective

(2020) Hisham F. Bahmad et al.   Cells

Cancer-Associated Angiogenesis: The Endothelial Cell as a Checkpoint for Immunological Patrolling

(2020) Antonio Giovanni Solimando et al.   Cancers

Fat mass and obesity-associated (FTO) and leptin receptor (LEPR) gene polymorphisms in Egyptian obese subjects

(2019) Ehab M. M. Ali et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3

(2019) Yi Niu et al.   Molecular Cancer

The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA

(2019) Jie Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation

(2019) Tongxing Song et al.   NUCLEIC ACIDS RESEARCH

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

(2019) Shiming Peng et al.   Science Translational Medicine

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

(2019) Seungwon Yang et al.   Nature Communications

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

(2019) Xinxia Wang et al.   Autophagy

The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells

(2019) Dongling Zou et al.   Cancer Cell International

m 6 A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression

(2018) Jiqin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Establishing a genetic link between FTO and VDR gene polymorphisms and obesity in the Emirati population

(2018) Saad Mahmud Khan et al.   BMC Medical Genetics

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair

(2018) Prabhu Mathiyalagan et al.   CIRCULATION

Analysis of the Impact of Common Polymorphisms of the FTO and MC4R Genes with the Risk of Severe Obesity in Saudi Arabian Population

(2018) Cyril Cyrus et al.   Genetic Testing and Molecular Biomarkers

Multiple genetic variations confer risks for obesity and type 2 diabetes mellitus in arab descendants from UAE

(2018) Wael Osman et al.   INTERNATIONAL JOURNAL OF OBESITY

Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

(2018) Ahmad Al-Serri et al.   MEDICAL PRINCIPLES AND PRACTICE

FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation

(2018) Shun Zhou et al.   MOLECULAR CARCINOGENESIS

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism

(2018) Ruifan Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of the fat mass and obesity‑associated protein in the proliferation of pancreatic cancer cells

(2018) Xiaodong Tang et al.   Oncology Letters

A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome

(2018) Su Su et al.   Cell Reports

The Emerging Role of Zfp217 in Adipogenesis

(2017) Hong Xiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

(2017) Marek Bartosovic et al.   NUCLEIC ACIDS RESEARCH

FTO expression is associated with the occurrence of gastric cancer and prognosis

(2017) Dong Xu et al.   ONCOLOGY REPORTS

The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway

(2017) Yazhuo Liu et al.   Oncology Letters

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine

(2017) Weiche Wu et al.   Scientific Reports

Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis

(2016) Xiaoyi Huang et al.   EUROPEAN JOURNAL OF CANCER CARE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

Estrogen promotes fat mass and obesity-associated protein nuclear localization and enhances endometrial cancer cell proliferation via the mTOR signaling pathway

(2016) YAPING ZHU et al.   ONCOLOGY REPORTS

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

mRNA m6A methylation downregulates adipogenesis in porcine adipocytes

(2015) Xinxia Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

DecreasedN6-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated WithFTOExpression Rather ThanALKBH5

(2015) Fan Shen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of a pathogenicFTOmutation by next-generation sequencing in a newborn with growth retardation and developmental delay

(2015) Hussein Daoud et al.   JOURNAL OF MEDICAL GENETICS

Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)

(2015) Wu He et al.   JOURNAL OF MEDICINAL CHEMISTRY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO

(2015) Joel D. W. Toh et al.   Chemical Science

FTO influences adipogenesis by regulating mitotic clonal expansion

(2015) Myrte Merkestein et al.   Nature Communications

The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation

(2015) Meizi Zhang et al.   PLoS One

Synthesis of a FTO Inhibitor with Anticonvulsant Activity

(2014) Guanqun Zheng et al.   ACS Chemical Neuroscience

Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

(2014) George Stratigopoulos et al.   Cell Metabolism

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Assessing the efficacy of targeting the phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway in endometrial cancer

(2014) Leslie S. Bradford et al.   GYNECOLOGIC ONCOLOGY

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case–control study in Japan

(2013) Yingsong Lin et al.   BMC CANCER

FTO Deficiency Induces UCP-1 Expression and Mitochondrial Uncoupling in Adipocytes

(2013) D. Tews et al.   ENDOCRINOLOGY

A link between FTO, ghrelin, and impaired brain food-cue responsivity

(2013) Efthimia Karra et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of interleukin 1β in the anti-adipogenic action of macrophages on human preadipocytes

(2013) AnneMarie Gagnon et al.   JOURNAL OF ENDOCRINOLOGY

Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)

(2013) WeiShen Aik et al.   JOURNAL OF MEDICINAL CHEMISTRY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

(2013) Montserrat Garcia-Closas et al.   NATURE GENETICS

A variant in FTO shows association with melanoma risk not due to BMI

(2013) Mark M Iles et al.   NATURE GENETICS

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

(2013) Keri L Monda et al.   NATURE GENETICS

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

(2013) Martin E Hess et al.   NATURE NEUROSCIENCE

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

(2013) Fiona McMurray et al.   PLoS Genetics

Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways

(2012) Zhenbo Zhang et al.   CANCER LETTERS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

(2012) Miwako Nishio et al.   Cell Metabolism

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

(2012) Baoen Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Meta-analysis identifies common variants associated with body mass index in east Asians

(2012) Wanqing Wen et al.   NATURE GENETICS

Associations of Variants inFTOand NearMC4RWith Obesity Traits in South Asian Indians

(2012) Senthil K. Vasan et al.   Obesity

Association of Obesity-related Genetic Variants With Endometrial Cancer Risk: A Report From the Shanghai Endometrial Cancer Genetics Study

(2011) R. J. Delahanty et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The role of the fat mass and obesity associated gene (FTO) in breast cancer risk

(2011) Virginia Kaklamani et al.   BMC Medical Genetics

Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma

(2011) Mohammed Tanjimur Rahman et al.   CANCER

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Body Mass Index and Obesity- and Diabetes-Associated Genotypes and Risk for Pancreatic Cancer

(2011) H. Tang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cross-Talk Between Interferon-  and Hedgehog Signaling Regulates Adipogenesis

(2011) J. Todoric et al.   DIABETES

An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference

(2011) S. D. Rees et al.   DIABETIC MEDICINE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

The Obesity-Associated Polymorphisms FTO rs9939609 and MC4R rs17782313 and Endometrial Cancer Risk in Non-Hispanic White Women

(2011) Galina Lurie et al.   PLoS One

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Cycling through metabolism

(2010) Victor Aguilar et al.   EMBO Molecular Medicine

The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels

(2010) Tea Berulava et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide linkage and peak-wide association study of obesity-related quantitative traits in Caribbean Hispanics

(2010) Chuanhui Dong et al.   HUMAN GENETICS

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

(2009) Sarah Boissel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

(2009) Yoon Shin Cho et al.   NATURE GENETICS

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Association Analysis of Variation in/Near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B With Type 2 Diabetes and Related Quantitative Traits in Pima Indians

(2008) R. Rong et al.   DIABETES

Variation in the FTO Gene Influences Food Intake but not Energy Expenditure

(2008) A. Haupt et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

The FTO gene and measured food intake in children

(2008) J Wardle et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity Associated Genetic Variation inFTOIs Associated with Diminished Satiety

(2008) Jane Wardle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Variations in the FTO gene are associated with severe obesity in the Japanese

(2008) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

An Obesity-AssociatedFTOGene Variant and Increased Energy Intake in Children

(2008) Joanne E. Cecil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymorphisms of theFTOGene Are Associated With Variation in Energy Intake, but not Energy Expenditure

(2008) John R. Speakman et al.   Obesity

TheFTOGene Is Associated With Adulthood Obesity in the Mexican Population

(2008) Marisela Villalobos-Comparán et al.   Obesity