The Phytochemical Rhein Mediates M6A-Independent Suppression of Adipocyte Differentiation

Multifaceted regulation of translation by the epitranscriptomic modification N6-methyladenosine

(2021) Xiao-Min Liu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A research update on the therapeutic potential of rhein and its derivatives

(2021) Li Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular Mechanism of Stem Cell Differentiation into Adipocytes and Adipocyte Differentiation of Malignant Tumor

(2020) Kexin Zhang et al.   Stem Cells International

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Assembling the adipose organ: adipocyte lineage segregation and adipogenesis in vivo

(2019) Zachary L. Sebo et al.   DEVELOPMENT

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation

(2019) Tongxing Song et al.   NUCLEIC ACIDS RESEARCH

REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis

(2019) Darshan Kumar et al.   MOLECULAR BIOLOGY OF THE CELL

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

(2019) Xinxia Wang et al.   Autophagy

m6A methylation modulates adipogenesis through JAK2-STAT3-C/EBPβ signaling

(2019) Ruifan Wu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m6A-YTHDF2-dependent manner

(2018) Ruifan Wu et al.   INTERNATIONAL JOURNAL OF OBESITY

N 6 -Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response

(2018) Jun Zhou et al.   MOLECULAR CELL

Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity

(2018) Jing Liu et al.   PHYTOMEDICINE

Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells

(2018) Sook-Kyoung Heo et al.   PHYTOMEDICINE

Improved heart failure by Rhein lysinate is associated with p38MAPK pathway

(2018) Wei Wang et al.   Experimental and Therapeutic Medicine

Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells

(2018) Li Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A novel Rhein derivative: Activation of Rac1/NADPH pathway enhances sensitivity of nasopharyngeal carcinoma cells to radiotherapy

(2018) Zhengying Su et al.   CELLULAR SIGNALLING

Rhein induces apoptosis and autophagy in human and rat glioma cells and mediates cell differentiation by ERK inhibition

(2017) Nan Tang et al.   MICROBIAL PATHOGENESIS

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

Rhein triggers apoptosis via induction of endoplasmic reticulum stress, caspase-4 and intracellular calcium in primary human hepatic HL-7702 cells

(2016) Arouna KoraMagazi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage

(2016) Qi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

(2016) Hao Sun et al.   Frontiers in Pharmacology

The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinase α1 subunit

(2015) Xihong Zhou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTO influences adipogenesis by regulating mitotic clonal expansion

(2015) Myrte Merkestein et al.   Nature Communications

The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation

(2015) Meizi Zhang et al.   PLoS One

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

A protocol for RNA methylation differential analysis with MeRIP-Seq data and exomePeak R/Bioconductor package

(2014) Jia Meng et al.   METHODS

REEP3/4 Ensure Endoplasmic Reticulum Clearance from Metaphase Chromatin and Proper Nuclear Envelope Architecture

(2013) Anne-Lore Schlaitz et al.   DEVELOPMENTAL CELL

Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing

(2013) Dan Dominissini et al.   Nature Protocols

The bigger picture of FTO—the first GWAS-identified obesity gene

(2013) Ruth J. F. Loos et al.   Nature Reviews Endocrinology

FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA

(2013) Ye Fu et al.   Nature Communications

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue

(2012) Xiaoyan Sheng et al.   International Journal of Biological Sciences

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

(2012) Baoen Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Adipogenesis

(2012) K. Sarjeant et al.   Cold Spring Harbor Perspectives in Biology

Rhein Induces Apoptosis in Human Breast Cancer Cells

(2011) Ching-Yao Chang et al.   Evidence-based Complementary and Alternative Medicine

Rhein, an inhibitor of adipocyte differentiation and adipogenesis

(2011) Qian Liu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Rhein Induces Apoptosis and Cell Cycle Arrest in Human Hepatocellular Carcinoma BEL-7402 Cells

(2008) Ping Shi et al.   AMERICAN JOURNAL OF CHINESE MEDICINE