Intervention and potential mechanism of non-starch polysaccharides from natural resources on ulcerative colitis: A review

Identification of bioactive polysaccharide from Pseudostellaria heterophylla with its anti-inflammatory effects

(2021) Siyuan You et al.   Journal of Functional Foods

Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii

(2021) Yuqing Sun et al.   CARBOHYDRATE POLYMERS

Protective effect of exopolysaccharide fraction from Bacillus subtilis against dextran sulfate sodium-induced colitis through maintenance of intestinal barrier and suppression of inflammatory responses

(2021) Kyung-Sook Chung et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

In-depth analysis of the mechanisms of aloe polysaccharides on mitigating subacute colitis in mice via microbiota informatics

(2021) Chang Liu et al.   CARBOHYDRATE POLYMERS

Dendrobium huoshanense Polysaccharides Prevent Inflammatory Response of Ulcerative Colitis Rat through Inhibiting the NF‐κB Signaling Pathway

(2021) Fang‐Li Gu et al.   CHEMISTRY & BIODIVERSITY

Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism

(2021) Chang Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function

(2021) Hongyu Xiao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Protective effects of sulfated polysaccharide from Enterobacter cloacae Z0206 against DSS-induced intestinal injury via DNA methylation

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Exopolysaccharides from Lactobacillus plantarum NCU116 Facilitate Intestinal Homeostasis by Modulating Intestinal Epithelial Regeneration and Microbiota

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Fuzhuan Brick Tea Polysaccharide Improved Ulcerative Colitis in Association with Gut Microbiota-Derived Tryptophan Metabolism

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Anti-Inflammatory Effects of Mytilus coruscus Polysaccharide on RAW264.7 Cells and DSS-Induced Colitis in Mice

(2021) Xing-Wei Xiang et al.   Marine Drugs

Rhamnogalacturonan polysaccharide inhibits inflammation and oxidative stress and alleviates visceral pain

(2021) Daniele Maria-Ferreira et al.   Journal of Functional Foods

Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses

(2021) Yu-Jing Wang et al.   Food & Function

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Polysaccharides: bowel health and gut microbiota

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The α-D-glucan from marine fungus Phoma herbarum YS4108 ameliorated mice colitis by repairing mucosal barrier and maintaining intestinal homeostasis

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Polysaccharide from flammuliana velutipes improves colitis via regulation of colonic microbial dysbiosis and inflammatory responses

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Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice by Angelica Sinensis Polysaccharide

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Extracts and Marine Algae Polysaccharides in Therapy and Prevention of Inflammatory Diseases of the Intestine

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Polysaccharide from Pycnoporus sanguineus ameliorates dextran sulfate sodium-induced colitis via helper T cells repertoire modulation and autophagy suppression

(2020) Muxia Li et al.   PHYTOTHERAPY RESEARCH

Sulfated polysaccharide extracted from seaweed Gracilaria caudata attenuates acetic acid-induced ulcerative colitis

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IL1B Increases Intestinal Tight Junction Permeability by Upregulation of MIR200C-3p, Which Degrades Occludin mRNA

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Anti-inflammatory properties and gut microbiota modulation of an alkali-soluble polysaccharide from purple sweet potato in DSS-induced colitis mice

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Polysaccharide isolated from Auricularia auricular‐judae (Bull.) prevents dextran sulfate sodium‐induced colitis in mice through modulating the composition of the gut microbiota

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Intervention with the crude polysaccharides of Physalis pubescens L . mitigates colitis by preventing oxidative damage, aberrant immune responses, and dysbacteriosis

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Cell death in the gut epithelium and implications for chronic inflammation

(2020) Jay V. Patankar et al.   Nature Reviews Gastroenterology & Hepatology

A Novel Non-Digestible, Carrot-Derived Polysaccharide (cRG-I) Selectively Modulates the Human Gut Microbiota while Promoting Gut Barrier Integrity: An Integrated In Vitro Approach

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Mucus barrier, mucins and gut microbiota: the expected slimy partners?

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Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis

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Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

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Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade

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The Anti-colitis Effect of Schisandra chinensis Polysaccharide Is Associated With the Regulation of the Composition and Metabolism of Gut Microbiota

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Polysaccharide from Gracilaria Lemaneiformis prevents colitis in Balb/c mice via enhancing intestinal barrier function and attenuating intestinal inflammation

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Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota

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Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms

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Structural features and anti-inflammatory properties of pectic polysaccharides: A review

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D-mannose suppresses macrophage IL-1β production

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Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia

(2020) Shu-Chen Wei et al.   Expert Review of Gastroenterology & Hepatology

Capsular Polysaccharide From Bacteroides fragilis Protects Against Ulcerative Colitis in an Undegraded Form

(2020) Lijun Zheng et al.   Frontiers in Pharmacology

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(2019) Guilherme Piovezani Ramos et al.   MAYO CLINIC PROCEEDINGS

Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance

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Destiny of Dendrobium officinale Polysaccharide after Oral Administration: Indigestible and Nonabsorbing, Ends in Modulating Gut Microbiota

(2019) Lifeng Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structural characterization of water-soluble polysaccharide from Arctium lappa and its effects on colitis mice

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Polysaccharide from Scutellaria baicalensis Georgi ameliorates colitis via suppressing NF-κB signaling and NLRP3 inflammasome activation

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Active cell migration is critical for steady-state epithelial turnover in the gut

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Maresin 1 alleviates dextran sulfate sodium-induced ulcerative colitis by regulating NRF2 and TLR4/NF-kB signaling pathway

(2019) Shujin Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protective effect and mechanism of polysaccharide from Dictyophora indusiata on dextran sodium sulfate-induced colitis in C57BL/6 mice

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Chitosan Ameliorates DSS-Induced Ulcerative Colitis Mice by Enhancing Intestinal Barrier Function and Improving Microflora

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Attenuation of DSS induced colitis by Dictyophora indusiata polysaccharide (DIP) via modulation of gut microbiota and inflammatory related signaling pathways

(2019) Sadia Kanwal et al.   Journal of Functional Foods

Polysaccharides derived from Morinda citrifolia Linn reduce inflammatory markers during experimental colitis

(2019) Jalles Arruda Batista et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dietary Fiber Pectin Ameliorates Experimental Colitis in a Neutral Sugar Side Chain-Dependent Manner

(2019) Keita Ishisono et al.   Frontiers in Immunology

Therapeutic roles of polysaccharides from Dendrobium Officinaleon colitis and its underlying mechanisms

(2018) Jian Liang et al.   CARBOHYDRATE POLYMERS

Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review

(2018) Yue Yu et al.   CARBOHYDRATE POLYMERS

Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice

(2018) Johanna Pott et al.   Cell Host & Microbe

Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Ulcerative Colitis

(2018) Sophie E. Berends et al.   CLINICAL PHARMACOKINETICS

New treatment options for inflammatory bowel diseases

(2018) Bram Verstockt et al.   JOURNAL OF GASTROENTEROLOGY

The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function

(2018) Saige L. Pompura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis

(2018) Srinivasan Periasamy et al.   Journal of Functional Foods

Polysaccharides From Chrysanthemum morifolium Ramat Ameliorate Colitis Rats via Regulation of the Metabolic Profiling and NF-κ B/TLR4 and IL-6/JAK2/STAT3 Signaling Pathways

(2018) Jin-Hua Tao et al.   Frontiers in Pharmacology

Natural and synthetic polymer-based smart biomaterials for management of ulcerative colitis: a review of recent developments and future prospects

(2018) Muhammad Sohail et al.   Drug Delivery and Translational Research

Pectic polysaccharides extracted from Rauvolfia verticillata (Lour.) Baill. var. hainanensis Tsiang ameliorate ulcerative colitis via regulating the MAPKs and NF-κB pathways in dendritic cells

(2018) Xin-Pu Miao et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Exopolysaccharides from Lactobacillus plantarum NCU116 Regulate Intestinal Barrier Function via STAT3 Signaling Pathway

(2018) Xingtao Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Attenuation of intestinal inflammation of polysaccharides from the seeds of Plantago asiatica L. as affected by ultrasonication

(2018) Danfei Huang et al.   JOURNAL OF FOOD BIOCHEMISTRY

Precision editing of the gut microbiota ameliorates colitis

(2018) Wenhan Zhu et al.   NATURE

Dietary polysaccharide-rich extract from Eucheuma cottonii modulates the inflammatory response and suppresses colonic injury on dextran sulfate sodium-induced colitis in mice

(2018) Sabri Sudirman et al.   PLoS One

Rhamnogalacturonan, a chemically-defined polysaccharide, improves intestinal barrier function in DSS-induced colitis in mice and human Caco-2 cells

(2018) Daniele Maria-Ferreira et al.   Scientific Reports

Fight them or feed them: how the intestinal mucus layer manages the gut microbiota

(2018) Bjoern O Schroeder   Gastroenterology Report

A polysaccharide from cultured mycelium of Hericium erinaceus relieves ulcerative colitis by counteracting oxidative stress and improving mitochondrial function

(2018) Dandan Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibition of dextran sodium sulfate-induced colitis in mice by baker’s yeast polysaccharides

(2018) Ying Sun et al.   CARBOHYDRATE POLYMERS

Structure characterization of a polysaccharide extracted from noni (Morinda citrifolia L.) and its protective effect against DSS-induced bowel disease in mice

(2018) Mingyu Jin et al.   FOOD HYDROCOLLOIDS

JAK inhibition in inflammatory bowel disease

(2017) Pablo Olivera et al.   Expert Review of Clinical Immunology

In vitro and in vivo gastrointestinal digestion and fermentation of the polysaccharide from Ganoderma atrum

(2017) Qiao Ding et al.   FOOD HYDROCOLLOIDS

Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-κВ activation

(2017) Jun Lv et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

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(2017) Marjorie Argollo et al.   JOURNAL OF AUTOIMMUNITY

Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management

(2017) Marcus Harbord et al.   Journal of Crohns & Colitis

Clinical characteristics of ulcerative colitis-related colorectal cancer in Chinese patients

(2017) Ya Nan Wang et al.   Journal of Digestive Diseases

Polysaccharides from Chrysanthemum morifolium Ramat ameliorate colitis rats by modulating the intestinal microbiota community

(2017) Jin-Hua Tao et al.   Oncotarget

Intestinal Anti-inflammatory Effects of Outer Membrane Vesicles from Escherichia coli Nissle 1917 in DSS-Experimental Colitis in Mice

(2017) María-José Fábrega et al.   Frontiers in Microbiology

Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier

(2017) Shui-Jiao Chen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

In vitro analysis of partially hydrolyzed guar gum fermentation on identified gut microbiota

(2016) Justin Carlson et al.   ANAEROBE

Probiotics and prebiotics in ulcerative colitis

(2016) Lauranne A.A.P. Derikx et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Intrinsic Defense Mechanisms of the Intestinal Epithelium

(2016) Deepshika Ramanan et al.   Cell Host & Microbe

Simultaneous determination of six short-chain fatty acids in colonic contents of colitis mice after oral administration of polysaccharides from Chrysanthemum morifolium Ramat by gas chromatography with flame ionization detector

(2016) Jin-hua Tao et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Astragaluspolysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches

(2016) Hai-Mei Zhao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

In vitro digestion and fermentation properties of linear sugar-beet arabinan and its oligosaccharides

(2015) Jin Seok Moon et al.   CARBOHYDRATE POLYMERS

Structure–function relationships of immunostimulatory polysaccharides: A review

(2015) Sónia S. Ferreira et al.   CARBOHYDRATE POLYMERS

Assessment of the Intestinal Barrier with Five Different Permeability Tests in Healthy C57BL/6J and BALB/cJ Mice

(2015) Valentina Volynets et al.   DIGESTIVE DISEASES AND SCIENCES

Genetics of Inflammatory Bowel Diseases

(2015) Dermot P.B. McGovern et al.   GASTROENTEROLOGY

Diet in the Pathogenesis and Treatment of Inflammatory Bowel Diseases

(2015) Dale Lee et al.   GASTROENTEROLOGY

Perturbations of mucosal homeostasis through interactions of intestinal microbes with myeloid cells

(2015) Regina Schey et al.   IMMUNOBIOLOGY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Combined Therapy with Rheum tanguticum Polysaccharide and Low-dose 5-ASA Ameliorates TNBS-Induced Colitis in Rats by Suppression of NF-κB

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Suppressive effect of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on inflammation by regulation of NF– κ B pathway and interleukin–17 in mice with dextran sulphatesodium–induced ulcerative colitis

(2015) Xin-Pu Miao et al.   Asian Pacific Journal of Tropical Medicine

Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice

(2015) Bo Liu et al.   Food & Function

Wild jujube polysaccharides protect against experimental inflammatory bowel disease by enabling enhanced intestinal barrier function

(2015) Yuan Yue et al.   Food & Function

Hirsutenone reduces deterioration of tight junction proteins through EGFR/Akt and ERK1/2 pathway both converging to HO-1 induction

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Effect of Astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis

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The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

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The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action

(2014) Linjing Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

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Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

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Glycobiome: Bacteria and mucus at the epithelial interface

(2013) Janneke P. Ouwerkerk et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

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(2013) Siew C Ng et al.   GUT

The gut microbiota and obesity: from correlation to causality

(2013) Liping Zhao   NATURE REVIEWS MICROBIOLOGY

A Balanced IL-1β Activity Is Required for Host Response to Citrobacter rodentium Infection

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Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1

(2013) Atsushi Iraha   WORLD JOURNAL OF GASTROENTEROLOGY

New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa

(2012) Ana Cristina Gomes-Santos et al.   Clinical & Developmental Immunology

Dietary Roles of Non-Starch Polysachharides in Human Nutrition: A Review

(2012) Vikas Kumar et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Healing of intestinal inflammation by IL-22

(2012) Atsushi Mizoguchi   INFLAMMATORY BOWEL DISEASES

Protective Role of Commensals against Clostridium difficile Infection via an IL-1 -Mediated Positive-Feedback Loop

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Techniques used to characterize the gut microbiota: a guide for the clinician

(2012) Marianne H. Fraher et al.   Nature Reviews Gastroenterology & Hepatology

Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications

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Pathological roles of MAPK signaling pathways in human diseases

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Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis

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PCNA on the crossroad of cancer

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Orally administered glucans from the edible mushroom Pleurotus pulmonarius reduce acute inflammation in dextran sulfate sodium-induced experimental colitis

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SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

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Beneficial effects of Bacteroides fragilis polysaccharides on the immune system

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Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: A clue to pathogenesis

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Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway

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Clinical implications of mucosal healing for the management of IBD

(2009) Guillaume Pineton de Chambrun et al.   Nature Reviews Gastroenterology & Hepatology

NF-κB p65 Antisense Oligonucleotides May Serve as a Novel Molecular Approach for the Treatment of Patients with Ulcerative Colitis

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Butyrate modulates oxidative stress in the colonic mucosa of healthy humans

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Microbes in Gastrointestinal Health and Disease

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A microbial symbiosis factor prevents intestinal inflammatory disease

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