Article
Biochemistry & Molecular Biology
Qun Zhao, Xinran Cheng, Jian Guo, Yun Bi, Li Kuang, Jianhua Ren, Jing Zhong, Longrui Pan, Xudong Zhang, Yang Guo, Yongqiang Liu, Shu Jin, Yan Tan, Xianjun Yu
Summary: MLKL plays a suppressive role in intestinal tumorigenesis by inhibiting the IL-6/JAK2/STAT3 signaling pathway, reducing the risk of intestinal tumor development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Jie Zhou, Jing Yue, Yu Yao, Pengfei Hou, Ting Zhang, Qianyong Zhang, Long Yi, Mantian Mi
Summary: Previous studies suggest that DHM has potential benefits in alleviating intestinal inflammation and improving intestinal barrier integrity, but the underlying mechanism is still unknown.
Article
Immunology
Kang Wang, Daiwen Chen, Bing Yu, Jun He, Xiangbing Mao, Zhiqing Huang, Hui Yan, Aimin Wu, Yuheng Luo, Ping Zheng, Jie Yu, Junqiu Luo
Summary: Increasing evidence supports that eugenol can alleviate virus-induced intestinal barrier damage and inflammation. Eugenol improved feed efficiency and increased immunoglobulin concentration while decreasing inflammatory cytokine concentration in virus-infected piglets. It also regulated the NF-kappa B signaling pathway and increased the expression of barrier and nutrient transporter-related genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Weilei Yao, Tongxin Wang, Lu Huang, Zhengxi Bao, Shu Wen, Feiruo Huang
Summary: The study demonstrated that embelin exerts protective effects against intestinal inflammation in weaned pigs by suppressing the PCAF/NF-kappa B signaling pathway, as evidenced by decreased serum D-lactate and diamine oxidase levels, increased expression of ZO-1, occludin and claudin-1 proteins in the jejunum and ileum, and downregulation of critical inflammatory molecules in the jejunal and ileal mucosa. Additionally, embelin also downregulated PCAF activity and attenuated the acetylation and activities of NF-kappa B in IPEC-1 cells with overexpression of PCAF.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shaoying Gong, Jiachen Zheng, Junjie Zhang, Jianchun Han
Summary: This study investigated the effect of benzo[a]pyrene (B[a]P) on the function of intestinal epithelial barrier (IEB) and the protective effect of arabinogalactan (AG) against B[a]P-induced IEB dysfunction using a Caco-2 cell monolayer model. B[a]P was found to damage the IEB integrity by inducing cell cytotoxicity, oxidative stress, pro-inflammatory cytokine secretion, down-regulation of tight junction proteins, and activation of the AhR/MAPK signaling pathway. However, AG mitigated B[a]P-induced IEB dysfunction by inhibiting oxidative stress and pro-inflammatory factor secretion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Xiaohan Wu, Shuchun Wei, Meilin Chen, Jinting Li, Yuping Wei, Jixiang Zhang, Weiguo Dong
Summary: P2Y13 is highly expressed in ulcerative colitis and can aggravate intestinal mucosal barrier destruction by activating the IL-6/STAT3 pathway, making it a potential drug target for UC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Xingtao Zhou, Duoduo Zhang, Wucheng Qi, Tao Hong, Tao Xiong, Tingqin Wu, Fang Geng, Mingyong Xie, Shaoping Nie
Summary: EPS116 promotes intestinal epithelial regeneration by increasing the number of intestinal stem cells and modulating the gut microbiota profile, thereby maintaining intestinal barrier and homeostasis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xia Dong, Yi Wang, Xiaoxiao Zhu, Linyuan Shen, Lei Chen, Lili Niu, Mailin Gan, Shunhua Zhang, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zhu, Ye Zhao
Summary: Our study demonstrated that an appropriate concentration of sodium butyrate (SB) can effectively alleviate intestinal mucosal mechanical barrier injury caused by rotavirus (RV) infection. SB up-regulated the expression of tight junction (TJ)-related genes, reduced oxidative stress, and restored intestinal mucosal mechanical barrier function. This protective effect was mediated by the activation of the AMPK-Nrf2 signaling pathway through the receptor GPR109A.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agriculture, Multidisciplinary
Juan Wang, Hui Zhao, Ke Lv, Wei Zhao, Ning Zhang, Fan Yang, Xiang Wen, Xiaohua Jiang, Jingrui Tian, Xinjuan Liu, Chi-Tang Ho, Shiming Li
Summary: Pterostilbene (PTE) protects intestinal epithelial barrier integrity through the NF-kappa B-MLCK/p-MLC signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yujuan Li, Shan Liu, Huayan Liu, Yaoyuan Cui, Yulin Deng
Summary: Dragon's Blood has been found to prevent intestinal epithelial barrier dysfunction induced by microgravity through repairing cell connections, inhibiting inflammatory responses, and promoting the formation of focal adhesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Na-Na Yang, Jing-Wen Yang, Yang Ye, Jin Huang, Lu Wang, Yu Wang, Xin-Tong Su, Ying Lin, Fang-Ting Yu, Si-Ming Ma, Ling-Yu Qi, Lu-Lu Lin, Li-Qiong Wang, Guang-Xia Shi, Hong-Ping Li, Cun-Zhi Liu
Summary: The study investigated how electroacupuncture stimulation at the hindlimb region ameliorates inflammation in postoperative ileus (POI). Results showed that electroacupuncture suppressed intestinal inflammation and promoted gastrointestinal motility by activating the alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR)-mediated JAK2/STAT3 signaling pathway in macrophages. Furthermore, hindlimb region stimulation inhibited the expression of GABA(A) receptor in dorsal motor nucleus of vagal (DMV) neurons, leading to suppression of inflammation via vagal efferent output.
Article
Plant Sciences
Zhihua Liu, Zhengxu Zhang, Xiaonan Chen, Ping Ma, Ying Peng, Xiaobo Li
Summary: This study investigated the protective effects and underlying mechanisms of citrate and hydroxycinnamate derivatives in Mume Fructus on intestinal epithelial injury. Network pharmacology analysis predicted multiple targets and pathways associated with Crohn's disease, and cell validation experiments confirmed the ability of these derivatives to promote cell proliferation and inhibit damage caused by lipopolysaccharide. Activation of the FAK/PI3K/AKT signaling pathway was identified as a potential mechanism for the protective effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Bing Yan, Xinjie Mao, Shasha Hu, Shimin Wang, Xiaochen Liu, Jing Sun
Summary: This study investigated the effects of spermidine on AhR and gut barrier function in IBD models. The results showed that spermidine significantly attenuated intestinal permeability, restored tight junction protein distribution, and prevented bacterial translocation. Additionally, spermidine increased AhR and Nrf2 expression while inhibiting STAT3 phosphorylation. The protective effects of spermidine were largely mediated through the AhR-Nrf2 and AhR-STAT3 pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jing Yang, Xiaoli Xie
Summary: The study revealed that tofacitinib could protect against intestinal ischemia/reperfusion injury by inhibiting the JAK/STAT3 signaling pathway, leading to reduced cell apoptosis, oxidative stress, and inflammation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: STAT3 plays a critical role in the development of colorectal cancer by enhancing tumor cell proliferation and growth through inflammatory mechanisms. However, the mechanisms underlying the role of STAT3 in tumor immunity are not fully understood, and STAT3 inhibitors have not yet been widely used in clinical practice.
Review
Food Science & Technology
Paz Otero, M. Carpena, P. Garcia-Oliveira, J. Echave, A. Soria-Lopez, P. Garcia-Perez, M. Fraga-Corral, Hui Cao, Shaoping Nie, Jianbo Xiao, J. Simal-Gandara, M. A. Prieto
Summary: Consumers nowadays are increasingly aware of the relationship between diet and health, leading to a preference for natural products. Seaweeds have emerged as a potential source of bioactive carbohydrates, with numerous polysaccharides arousing the interest of the scientific community due to their biological activities. Environmentally friendly extraction technologies and chemical modification methods have been developed to improve the yield, quality, and applications of seaweed polysaccharides. This review aims to compile current information about seaweed polysaccharides, including extraction and modification methods, biological activities, and future trends for their industrial applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Song Li, Jielun Hu, Haoyingye Yao, Fang Geng, Shaoping Nie
Summary: This review explores the effects of different galactans on gut microbiota and the production of short-chain fatty acids. It summarizes the structural characteristics of four types of galactans and discusses the ability of gut microbiota to utilize them. The findings suggest potential applications of galactans as functional foods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Bing Zheng, Xingtao Zhou, Xiaobo Hu, Yi Chen, Jianhua Xie, Qiang Yu
Summary: Polysaccharides have various biological activities, making them a potential natural drug for treating diseases. Apoptosis and autophagy play important roles in human health, and the regulation of apoptosis and autophagy by polysaccharides varies in different disease models. This review summarizes the relationship between apoptosis/autophagy and common human diseases, and discusses the role of apoptosis/autophagy pathway in regulating human health by polysaccharides.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Jia-Jia Wen, Ming-Zhi Li, Chun-Hua Chen, Tao Hong, Jing-Rui Yang, Xiao-Jun Huang, Fang Geng, Jie-Lun Hu, Shao-Ping Nie
Summary: Tea polyphenol (TP) and epigallocatechin gallate (EGCG) can improve hyperlipidemia and liver fat accumulation by regulating gut microbiota and promoting gut health.
Article
Agriculture, Multidisciplinary
Tongwen Huang, Ke Zhang, Junqiao Wang, Kaihong He, Xingtao Zhou, Shaoping Nie
Summary: This study found that quercetin can alleviate the hepatotoxicity caused by acrylamide generated in heat-treated foods. Experiments on mice showed that quercetin can reduce the oxidative stress levels induced by acrylamide and protect the liver from damage. The results demonstrated that quercetin suppressed acrylamide-induced ferroptosis by inhibiting oxidative stress-driven autophagy, leading to the mitigation of liver injury.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Jinjin Liu, Junyi Yin, Xiaojun Huang, Cencen Liu, Liuyun Hu, Yansheng Huang, Fang Geng, Shaoping Nie
Summary: This study aimed to remove the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) using baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT). Results showed that AT had the best removal effect on total anthraquinones and increased the content of neutral sugars in CWEs. However, AT decreased the antioxidant activity of CWEs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Yu Wu, Wengan Zhou, RuTing Feng, Duoduo Zhang, Yongkang Yu, Zuanyuan Huang, Junyi Yin, Xingtao Zhou, Shaoping Nie
Summary: The immunomodulatory effects of glucan from fruit body of Dictyophora rubrovolvata (DRP) were evaluated in this study. It was found that DRP can recover CTX-induced immunosuppression and activate dendritic cells (DCs) to increase cytokine secretion. The study also revealed that DRP regulates the AKT-STAT1 signaling pathway via Mincle in DCs to induce CD4(+) T cell proliferation and differentiation, thereby ameliorating CTX-induced immunosuppression.
Article
Food Science & Technology
Shanshan Zhang, Yonggan Sun, Qixing Nie, Jielun Hu, Wenwen Su, Zheyu Guo, Yanli Zhang, Shaoping Nie
Summary: Polysaccharides are commonly used as carriers for colon-targeted drugs, but their degradation and effects on gut microbiota in colitis conditions are unclear. In this study, the fermentation of four polysaccharides using colonic content microbiota from mice with colitis was performed. The results show that pectin and guar gum have a greater degree of degradation and promote the production of beneficial bacteria, while carrageenan and xanthan gum promote the proliferation of harmful bacteria.
Article
Chemistry, Multidisciplinary
Anqi Xie, Haihua Ji, Zheyi Liu, Yiqun Wan, Xuecong Zhang, Huihuang Xiong, Shao-Ping Nie, Hao Wan
Summary: Oral administration of probiotics is a promising method to alleviate inflammatory bowel diseases (IBDs), but sensitivity to the gastrointestinal environment and poor intestinal colonization hinder their effectiveness. In this study, a modified prebiotic-based shield (Fe-TA@mGN) was developed to enhance the stress resistance ability and intestinal colonization of Escherichia coli Nissle 1917 (EcN). The shield improved the survival rate of EcN and its retention in the intestine, leading to efficient alleviation of colitis. Additionally, the shield synergized with EcN to regulate gut microbiota and promote the production of short-chain fatty acids, further enhancing the alleviation of colitis.
Article
Chemistry, Applied
Ziwei Wang, Kunying Chen, Ke Zhang, Kaihong He, Duoduo Zhang, Xiaohan Guo, Tongwen Huang, Jielun Hu, Xingtao Zhou, Shaoping Nie
Summary: ACP inhibits proliferation of colorectal cancer cells by inducing apoptosis and lysosomal dysfunction through regulation of mitochondria, lysosome, and apoptosis-related pathways. It also increases histone H3-lysine-27 acetylation (H3K27ac) on CTSD promoter, facilitating TFEB binding and CTSD expression. ACP has potential as an anti-cancer agent for colorectal cancer treatment.
CARBOHYDRATE POLYMERS
(2023)
Review
Food Science & Technology
Duoduo Zhang, Xingtao Zhou, Wengan Zhou, Steve W. Cui, Shaoping Nie
Summary: This paper summarizes the complex mechanisms through which dietary nutrients regulate intestinal homeostasis, and introduces the application and advantages of intestinal organoid (IO) in investigating the interaction between nutrients and intestinal balance. It also highlights the importance of using IOs to study the mechanisms of macronutrients and micronutrients on intestinal homeostasis, as well as their potential in precision nutrition research.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Qianhuang Xiao, Wenqi Huang, Quanyong Wu, Hedi Xu, Yanli Zhang, Jingrui Yang, Shuigen Bian, Huizi Tan, Shaoping Nie
Summary: A sedentary lifestyle, unhealthy diet, and antibiotic use have been associated with an increased incidence of metabolic disorders and inflammation. This study focused on the effects of pectin, an edible polysaccharide, with different esterification degrees on mice treated with a high-fat diet and low-dose antibiotics. The results showed that different types of pectin had differential effects on metabolic health, inflammatory markers, gut microbiota, and serum metabolome.
Meeting Abstract
Oncology
Kelly E. Rentscher, Wanting Zhai, Brent J. Small, Jaeil Ahn, Tim A. Ahles, Traci N. Bethea, Elizabeth C. Breen, Harvey J. Cohen, Martine Extermann, Deena M. A. Graham, Paul B. Jacobsen, Heather S. L. Jim, Brenna C. McDonald, Zev M. Nakamura, Sunita K. Patel, James C. Root, Andrew J. Saykin, Danielle B. Tometich, Kathleen M. Van Dyk, Xingtao Zhou, Jeanne S. Mandelblatt, Judith E. Carroll
Article
Agriculture, Multidisciplinary
Shi-Kang Chen, Yu-Hao Li, Xin Wang, Yu-Qing Guo, Xiao-Xiao Song, Shao-Ping Nie, Jun-Yi Yin
Summary: In this study, the structural order of Hericium erinaceus polysaccharides from different regions was evaluated using several analysis methods, revealing various structural types including fucogalactoglucan, glucofucogalactan, fucoglucan, and glucan. The main chains of heterogalactans consist of alpha-(1 -> 6)-Galp residues, which may be substituted by Fucp and Galp residues at O-2.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)