Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier

Long-Term Alteration of Intestinal Microbiota in Patients with Ulcerative Colitis by Antibiotic Combination Therapy

(2014) Shigeo Koido et al.   PLoS One

Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case–control study in India

(2013) Jayakanthan Kabeerdoss et al.   BMC GASTROENTEROLOGY

Possible role of Escherichia coli in propagation and perpetuation of chronic inflammation in ulcerative colitis

(2013) Magdalena Pilarczyk-Zurek et al.   BMC GASTROENTEROLOGY

Lecithin as a Therapeutic Agent in Ulcerative Colitis

(2013) Wolfgang Stremmel et al.   DIGESTIVE DISEASES

Small Intestinal Bacterial Overgrowth and Orocecal Transit Time in Patients of Inflammatory Bowel Disease

(2013) S. V. Rana et al.   DIGESTIVE DISEASES AND SCIENCES

Mesalazine for the treatment of inflammatory bowel disease

(2013) Valeria Criscuoli et al.   EXPERT OPINION ON PHARMACOTHERAPY

Protective effect of Bauhinia tomentosa on acetic acid induced ulcerative colitis by regulating antioxidant and inflammatory mediators

(2013) Narayanan Kannan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In vitrobatch cultures of gut microbiota from healthy and ulcerative colitis (UC) subjects suggest that sulphate-reducing bacteria levels are raised in UC and by a protein-rich diet

(2013) Nazeha A. Khalil et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Site-specificO-Glycosylation on the MUC2 Mucin Protein Inhibits Cleavage by thePorphyromonas gingivalisSecreted Cysteine Protease (RgpB)

(2013) Sjoerd van der Post et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Proportions of Bifidobacterium and the Lactobacillus Group and Loss of Butyrate-Producing Bacteria in Inflammatory Bowel Disease

(2013) W. Wang et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic StrainLactobacillus caseiShirota

(2013) Elizabeth R. Mann et al.   MEDIATORS OF INFLAMMATION

A Modular Organization of the Human Intestinal Mucosal Microbiota and Its Association with Inflammatory Bowel Disease

(2013) Maomeng Tong et al.   PLoS One

Fluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India

(2013) Reena Kumari   WORLD JOURNAL OF GASTROENTEROLOGY

Mukosaschutz durch Phosphatidylcholin als neues therapeutisches Prinzip bei der Colitis ulcerosa

(2013) W. Stremmel   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Mucosal Barrier in Ulcerative Colitis and Crohn’s Disease

(2013) A. E. Dorofeyev et al.   Gastroenterology Research and Practice

Reduced Diversity and Imbalance of Fecal Microbiota in Patients with Ulcerative Colitis

(2012) Hideyuki Nemoto et al.   DIGESTIVE DISEASES AND SCIENCES

Probiotics in the Management of Inflammatory Bowel Disease

(2012) Daisy Jonkers et al.   DRUGS

Innate immune dysfunction in inflammatory bowel disease

(2012) M. Gersemann et al.   JOURNAL OF INTERNAL MEDICINE

Patients with Inflammatory Bowel Disease Exhibit Dysregulated Responses to Microbial DNA

(2012) Naomi S. C. Hotte et al.   PLoS One

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins

(2012) Malin E. V. Johansson   PLoS One

Lactobacillus reuteri Maintains a Functional Mucosal Barrier during DSS Treatment Despite Mucus Layer Dysfunction

(2012) Johan Dicksved et al.   PLoS One

Lactobacillus crispatusM206119 exacerbates murine DSS-colitis by interfering with inflammatory responses

(2012) Fu-Xi Zhou   WORLD JOURNAL OF GASTROENTEROLOGY

Etiology of inflammatory bowel disease: A unified hypothesis

(2012) Xiaofa Qin   WORLD JOURNAL OF GASTROENTEROLOGY

Gram-negative bacteria account for main differences between faecal microbiota from patients with ulcerative colitis and healthy controls

(2012) L.K. Vigsnæs et al.   Beneficial Microbes

Innate Immunity Modulation by the IL-33/ST2 System in Intestinal Mucosa

(2012) Marina García-Miguel et al.   Biomed Research International

Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis

(2011) S. Oliva et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota

(2011) Samah O Noor et al.   BMC GASTROENTEROLOGY

Role of mucus layers in gut infection and inflammation

(2011) Gunnar C Hansson   CURRENT OPINION IN MICROBIOLOGY

Beneficial Effects of Probiotic Bifidobacterium and Galacto-Oligosaccharide in Patients with Ulcerative Colitis: A Randomized Controlled Study

(2011) Hideki Ishikawa et al.   DIGESTION

Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis

(2011) Patricia Lepage et al.   GASTROENTEROLOGY

Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis

(2011) Xiu Zheng et al.   INFLAMMATORY BOWEL DISEASES

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

(2011) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Enterohepatic Helicobacter in Ulcerative Colitis: Potential Pathogenic Entities?

(2011) John M. Thomson et al.   PLoS One

Detection of Campylobacter concisus and Other Campylobacter Species in Colonic Biopsies from Adults with Ulcerative Colitis

(2011) Indrani Mukhopadhya et al.   PLoS One

Tumor Necrosis Factor-α and Muc2 Mucin Play Major Roles in Disease Onset and Progression in Dextran Sodium Sulphate-Induced Colitis

(2011) Poonam Dharmani et al.   PLoS One

Probiotics in Inflammatory Bowel Diseases and Associated Conditions

(2011) David Mack   Nutrients

“Omics” as the filtering gateway between environment and phenotype: The inflammatory bowel diseases example

(2010) Richard Kellermayer   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

(2010) J. Petersson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Clinical trial: probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN)

(2010) Harald Matthes et al.   BMC Complementary and Alternative Medicine

Rectal Administration of Lactobacillus casei DG Modifies Flora Composition and Toll-Like Receptor Expression in Colonic Mucosa of Patients with Mild Ulcerative Colitis

(2010) Renata D’Incà et al.   DIGESTIVE DISEASES AND SCIENCES

Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease

(2010) Shadi Sepehri et al.   INFLAMMATORY BOWEL DISEASES

Real-Time Analysis of Mucosal Flora in Patients with Inflammatory Bowel Disease in India

(2010) R. Verma et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The Asia-Pacific consensus on ulcerative colitis

(2010) Choon Jin Ooi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Extracellular proteins secreted by probiotic bacteria as mediators of effects that promote mucosa-bacteria interactions

(2010) B. Sanchez et al.   MICROBIOLOGY-SGM

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of probiotics on pro-inflammatory cytokines and NF-κB activation in ulcerative colitis

(2010) Sahar K Hegazy   WORLD JOURNAL OF GASTROENTEROLOGY

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

(2010) Kirk S. B. Bergstrom et al.   PLoS Pathogens

Effect of a Probiotic Preparation (VSL#3) on Induction and Maintenance of Remission in Children With Ulcerative Colitis

(2009) Erasmo Miele et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

(2009) Nanda Burger-van Paassen et al.   BIOCHEMICAL JOURNAL

Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis

(2009) T. Ohkusa et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein

(2009) Malin E. V. Johansson et al.   JOURNAL OF PROTEOME RESEARCH

A randomized controlled trial on the efficacy of synbiotic versus probiotic or prebiotic treatment to improve the quality of life in patients with ulcerative colitis

(2009) Shunji Fujimori et al.   NUTRITION

Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts

(2009) Lisa D Kalischuk et al.   Gut Pathogens

Epidermal Growth Factor Inhibits Campylobacter jejuni-Induced Claudin-4 Disruption, Loss of Epithelial Barrier Function, and Escherichia coli Translocation

(2008) J. M. Lamb-Rosteski et al.   INFECTION AND IMMUNITY

Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohnʼs disease

(2008) Ben Willing et al.   INFLAMMATORY BOWEL DISEASES

Role of Intestinal Mucins in Innate Host Defense Mechanisms against Pathogens

(2008) Poonam Dharmani et al.   Journal of Innate Immunity

Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases

(2008) C. D. Packey et al.   JOURNAL OF INTERNAL MEDICINE

Mucin Dynamics in Intestinal Bacterial Infection

(2008) Sara K. Lindén et al.   PLoS One

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA