CRISPR/Cas9: Regulations and challenges for law enforcement to combat its dual-use

The CRISPR-Cas Mechanism for Adaptive Immunity and Alternate Bacterial Functions Fuels Diverse Biotechnologies

(2021) Sydney Newsom et al.   Frontiers in Cellular and Infection Microbiology

Application of CRISPR/Cas9 in Crop Quality Improvement

(2021) Qier Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulatory approaches for genome edited agricultural plants in select countries and jurisdictions around the world

(2021) Jon Entine et al.   TRANSGENIC RESEARCH

Marker-free carotenoid-enriched rice generated through targeted gene insertion using CRISPR-Cas9

(2020) Oliver Xiaoou Dong et al.   Nature Communications

Biofortification of Pulse Crops: Status and Future Perspectives

(2020) Ambuj B. Jha et al.   Plants-Basel

CRISPR-Cas9 system: a genome-editing tool with endless possibilities

(2020) Swati Tyagi et al.   JOURNAL OF BIOTECHNOLOGY

Superior field performance of waxy corn engineered using CRISPR–Cas9

(2020) Huirong Gao et al.   NATURE BIOTECHNOLOGY

Genome editing with the CRISPR‐Cas system: an art, ethics and global regulatory perspective

(2020) Debin Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

Creating novel Wx alleles with fine‐tuned amylose levels and improved grain quality in rice by promoter editing using CRISPR/Cas9 system

(2020) Lichun Huang et al.   PLANT BIOTECHNOLOGY JOURNAL

The rin, nor and Cnr spontaneous mutations inhibit tomato fruit ripening in additive and epistatic manners

(2020) Rufang Wang et al.   PLANT SCIENCE

ENOregulates tomato fruit size through the floral meristem development network

(2020) Fernando J. Yuste-Lisbona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An In Vivo Targeted Deletion of the Calmodulin-Binding Domain from Rice Glutamate Decarboxylase 3 (OsGAD3) Increases γ-Aminobutyric Acid Content in Grains

(2020) Kazuhito Akama et al.   Rice

Applying genomic resources to accelerate wheat biofortification

(2020) Muhammad Waqas Ali et al.   HEREDITY

Conflict of Interest in Scientific Research in China: A Socio-ethical Analysis of He Jiankui’s Human Genome-editing Experiment

(2020) Jing-Bao Nie et al.   Journal of Bioethical Inquiry

Creation of novel alleles of fragrance gene OsBADH2 in rice through CRISPR/Cas9 mediated gene editing

(2020) Shanthinie Ashokkumar et al.   PLoS One

Forensic Autosomal Short Tandem Repeats and Their Potential Association With Phenotype

(2020) Nicole Wyner et al.   Frontiers in Genetics

CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future

(2020) Fathema Uddin et al.   Frontiers in Oncology

CRISPR-Cas9 System for Plant Genome Editing: Current Approaches and Emerging Developments

(2020) Jake Adolf V. Montecillo et al.   Agronomy-Basel

Rewriting the human genome, rewriting human rights law? Human rights, human dignity, and human germline modification in the CRISPR era

(2020) Britta C van Beers   Journal of Law and the Biosciences

Ethical and regulatory issues in human gene editing: Chinese perspective

(2020) Ruipeng Lei   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Simultaneous targeting of duplicated genes in Petunia protoplasts for flower color modification via CRISPR-Cas9 ribonucleoproteins

(2020) Jihyeon Yu et al.   PLANT CELL REPORTS

In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells

(2020) M. Martinez-Lage et al.   Nature Communications

Color-related chlorophyll and carotenoid concentrations of Chinese kale can be altered through CRISPR/Cas9 targeted editing of the carotenoid isomerase gene BoaCRTISO

(2020) Bo Sun et al.   Horticulture Research

Human Germ Line and Heritable Genome Editing: The Global Policy Landscape

(2020) Françoise Baylis et al.   CRISPR Journal

CRISPR/Cas9‐mediated Genome Editing of MaACO1 (aminocyclopropane‐1‐carboxylate oxidase1) Promotes the Shelf Life of Banana Fruit

(2020) Chunhua Hu et al.   PLANT BIOTECHNOLOGY JOURNAL

Did a permissive scientific culture encourage the ‘CRISPR babies’ experiment?

(2019) Donna Dickenson et al.   NATURE BIOTECHNOLOGY

Applications of the CRISPR/Cas9 System for Rice Grain Quality Improvement: Perspectives and Opportunities

(2019) Sajid Fiaz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

“CRISPR babies”: What does this mean for science and Canada?

(2019) Bartha Maria Knoppers et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Cas9‐mediated mutagenesis of potato starch‐branching enzymes generates a range of tuber starch phenotypes

(2019) Aytug Tuncel et al.   PLANT BIOTECHNOLOGY JOURNAL

Supersweet and waxy: meeting the diverse demands for specialty maize by genome editing

(2019) Le Dong et al.   PLANT BIOTECHNOLOGY JOURNAL

The Solanum tuberosum GBSSI gene: a target for assessing gene and base editing in tetraploid potato

(2019) Florian Veillet et al.   PLANT CELL REPORTS

Application of CRISPR/Cas9 gene editing technique in the study of cancer treatment

(2019) Chunyang Jiang et al.   CLINICAL GENETICS

After the fact—the case of CRISPR babies

(2019) Martin Sand et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

CRISPR–Cas in mobile genetic elements: counter-defence and beyond

(2019) Guilhem Faure et al.   NATURE REVIEWS MICROBIOLOGY

Gene editing of the wheat homologs of TONNEAU 1‐recruiting motif encoding gene affects grain shape and weight in wheat

(2019) Wei Wang et al.   PLANT JOURNAL

Changing Carrot Color: Insertions in DcMYB7 Alter the Regulation of Anthocyanin Biosynthesis and Modification

(2019) Zhi-Sheng Xu et al.   PLANT PHYSIOLOGY

Regulation of genome edited technologies in India

(2019) Murali Krishna Chimata et al.   TRANSGENIC RESEARCH

CRISPR/Cas9-Based Mutagenesis of Starch Biosynthetic Genes in Sweet Potato (Ipomoea Batatas) for the Improvement of Starch Quality

(2019) Hongxia Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’*

(2019) Henry T Greely   Journal of Law and the Biosciences

Rapid breeding of pink-fruited tomato hybrids using the CRISPR/Cas9 system

(2019) Tianxia Yang et al.   Journal of Genetics and Genomics

A CRISPR-Cas9 System for Genome Editing of Fusarium proliferatum

(2019) Massimo Ferrara et al.   Scientific Reports

Application of Genome Editing Techniques in Immunology

(2018) Agata O. Zych et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Delivering CRISPR: a review of the challenges and approaches

(2018) Christopher A. Lino et al.   DRUG DELIVERY

Risk analysis for genome editing-derived food safety in China

(2018) Wei Gao et al.   FOOD CONTROL

A Menagerie of Moral Hazards: Regulating Genetically Modified Animals

(2018) Sarah Polcz et al.   JOURNAL OF LAW MEDICINE & ETHICS

CRISPR/Cas9-mediated genome editing of the fatty acid desaturase 2 gene in Brassica napus

(2018) Ayako Okuzaki et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Development of muscular dystrophy in a CRISPR-engineered mutant rabbit model with frame-disrupting ANO5 mutations

(2018) Tingting Sui et al.   Cell Death & Disease

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Lycopene Is Enriched in Tomato Fruit by CRISPR/Cas9-Mediated Multiplex Genome Editing

(2018) Xindi Li et al.   Frontiers in Plant Science

Multiplex QTL editing of grain-related genes improves yield in elite rice varieties

(2018) Jianping Zhou et al.   PLANT CELL REPORTS

Application of the CRISPR/Cas9 system for modification of flower color in Torenia fournieri

(2018) Masahiro Nishihara et al.   BMC PLANT BIOLOGY

Mosaicism in CRISPR/Cas9-mediated genome editing

(2018) Maryam Mehravar et al.   DEVELOPMENTAL BIOLOGY

Protein Targeting to Starch 1 is essential for starchy endosperm development in barley

(2018) Yingxin Zhong et al.   JOURNAL OF EXPERIMENTAL BOTANY

De novo domestication of wild tomato using genome editing

(2018) Agustin Zsögön et al.   NATURE BIOTECHNOLOGY

A technological and regulatory outlook on CRISPR crop editing

(2017) Rea Globus et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A history of genome editing in mammals

(2017) Almudena Fernández et al.   MAMMALIAN GENOME

COL7A1 Editing via CRISPR/Cas9 in Recessive Dystrophic Epidermolysis Bullosa

(2017) Stefan Hainzl et al.   MOLECULAR THERAPY

Correction of a pathogenic gene mutation in human embryos

(2017) Hong Ma et al.   NATURE

Genome-wide target specificities of CRISPR RNA-guided programmable deaminases

(2017) Daesik Kim et al.   NATURE BIOTECHNOLOGY

Silencing of SlPL , which encodes a pectate lyase in tomato, confers enhanced fruit firmness, prolonged shelf-life and reduced susceptibility to grey mould

(2017) Lu Yang et al.   PLANT BIOTECHNOLOGY JOURNAL

Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9

(2017) Susana Sánchez-León et al.   PLANT BIOTECHNOLOGY JOURNAL

Antiviral Goes Viral: Harnessing CRISPR/Cas9 to Combat Viruses in Humans

(2017) Jasper Adriaan Soppe et al.   TRENDS IN MICROBIOLOGY

Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC

(2017) Deborah Y. Kwon et al.   Nature Communications

Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield

(2017) Li Tang et al.   Scientific Reports

CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice

(2017) Tsukasa Ohmori et al.   Scientific Reports

Gene editing using CRISPR/Cas9: implications for dual-use and biosecurity

(2017) Diane DiEuliis et al.   Protein & Cell

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

(2017) Lixia Wang et al.   Protein & Cell

Generation of High-Amylose Rice through CRISPR/Cas9-Mediated Targeted Mutagenesis of Starch Branching Enzymes

(2017) Yongwei Sun et al.   Frontiers in Plant Science

CRISPR/Cas9 Mediated Genome Engineering for Improvement of Horticultural Crops

(2017) Suhas G. Karkute et al.   Frontiers in Plant Science

CRISPR/Cas9-Mediated Genome Editing Corrects Dystrophin Mutation in Skeletal Muscle Stem Cells in a Mouse Model of Muscle Dystrophy

(2017) Pei Zhu et al.   Molecular Therapy-Nucleic Acids

One-Step Biallelic and Scarless Correction of a β-Thalassemia Mutation in Patient-Specific iPSCs without Drug Selection

(2017) Yali Liu et al.   Molecular Therapy-Nucleic Acids

CRISPR/Cas9-induced Targeted Mutagenesis and Gene Replacement to Generate Long-shelf Life Tomato Lines

(2017) Qing-hui Yu et al.   Scientific Reports

Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice

(2016) Ling Li et al.   ACS Nano

CRISPR/Cas9 Immune System as a Tool for Genome Engineering

(2016) Magdalena Hryhorowicz et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

CRISPR-Cas9 Targeting ofPCSK9in Human Hepatocytes In Vivo—Brief ReportSignificance

(2016) Xiao Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Editing DNA Methylation in the Mammalian Genome

(2016) X. Shawn Liu et al.   CELL

Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering

(2016) Addison V. Wright et al.   CELL

Rapid improvement of grain weight via highly efficient CRISPR/Cas9-mediated multiplex genome editing in rice

(2016) Rongfang Xu et al.   Journal of Genetics and Genomics

Efficiency and Inheritance of Targeted Mutagenesis in Maize Using CRISPR-Cas9

(2016) Jinjie Zhu et al.   Journal of Genetics and Genomics

QTL editing confers opposing yield performance in different rice varieties

(2016) Lan Shen et al.   Journal of Integrative Plant Biology

A proposed regulatory framework for genome-edited crops

(2016) Sanwen Huang et al.   NATURE GENETICS

BananaMaMADSTranscription Factors Are Necessary for Fruit Ripening and Molecular Tools to Promote Shelf-Life and Food Security

(2016) Tomer Elitzur et al.   PLANT PHYSIOLOGY

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

(2016) Ferdy R. van Diemen et al.   PLoS Pathogens

Canadian regulatory perspectives on genome engineered crops

(2016) Stuart J. Smyth   GM Crops & Food-Biotechnology in Agriculture and the Food Chain

CRISPR/Cas9-mediated efficient targeted mutagenesis in Chardonnay (Vitis vinifera L.)

(2016) Chong Ren et al.   Scientific Reports

Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9

(2015) Chul-Yong Park et al.   Cell Stem Cell

CRISPR-Cas9: a new and promising player in gene therapy

(2015) Lu Xiao-Jie et al.   JOURNAL OF MEDICAL GENETICS

Functional annotation of native enhancers with a Cas9–histone demethylase fusion

(2015) Nicola A Kearns et al.   NATURE METHODS

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

(2015) Pratiksha I Thakore et al.   NATURE METHODS

The future of forensic DNA analysis

(2015) John M. Butler   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Creation of fragrant rice by targeted knockout of theOsBADH2gene using TALEN technology

(2015) Qiwei Shan et al.   PLANT BIOTECHNOLOGY JOURNAL

The Regulatory Status of Genome-edited Crops

(2015) Jeffrey D. Wolt et al.   PLANT BIOTECHNOLOGY JOURNAL

Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs

(2015) Amy L. Firth et al.   Cell Reports

Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting

(2015) Chia-Wei Chang et al.   Cell Reports

CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells

(2015) Weixia Jing et al.   Biomed Research International

Sustainability Council of New Zealand Trust v. The Environmental Protection Authority: Gene editing technologies and the law

(2015) Drew L Kershen   GM Crops & Food-Biotechnology in Agriculture and the Food Chain

CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection

(2015) Hassen S. Wollebo et al.   PLoS One

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9

(2014) Rajat M. Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

International regulatory landscape and integration of corrective genome editing into in vitro fertilization

(2014) Motoko Araki et al.   Reproductive Biology and Endocrinology

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

(2014) Su-Ru Lin et al.   Molecular Therapy-Nucleic Acids

Pathogenesis of virus-associated human cancers: Epstein–Barr virus and hepatitis B virus as two examples

(2013) Kung-Chao Chang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

Long-term postharvest aroma evolution of tomatoes with the alcobaça (alc) mutation

(2011) Joan Casals et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY