A history of genome editing in mammals

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene

(2017) Ki-Eun Park et al.   Scientific Reports

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE

(2017) Marie-Christine Birling et al.   Scientific Reports

A comprehensive overview of computational resources to aid in precision genome editing with engineered nucleases

(2016) Vinita Periwal   BRIEFINGS IN BIOINFORMATICS

Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing

(2016) Xiangjin Kang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

(2016) Keiichiro Suzuki et al.   NATURE

New CRISPR–Cas systems from uncultivated microbes

(2016) David Burstein et al.   NATURE

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Generation of Knock-In Pigs Carrying Oct4-tdTomato Reporter through CRISPR/Cas9-Mediated Genome Engineering

(2016) Sisi Lai et al.   PLoS One

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system

(2016) R.J. Bevacqua et al.   THERIOGENOLOGY

Gene targeting, genome editing: from Dolly to editors

(2016) Wenfang Tan et al.   TRANSGENIC RESEARCH

The production of multi-transgenic pigs: update and perspectives for xenotransplantation

(2016) Heiner Niemann et al.   TRANSGENIC RESEARCH

On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals

(2016) Francisco J.M. Mojica et al.   TRENDS IN MICROBIOLOGY

One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

(2016) Xianlong Wang et al.   Scientific Reports

Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system

(2016) Rihong Guo et al.   Scientific Reports

Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9

(2016) Qingyan Lv et al.   Scientific Reports

Mammalian interspecies substitution of immune modulatory alleles by genome editing

(2016) Simon G. Lillico et al.   Scientific Reports

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions

(2015) Darío G. Lupiáñez et al.   CELL

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

(2015) Ya Guo et al.   CELL

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Clinical Translation of TALENS: Treating SCID-X1 by Gene Editing in iPSCs

(2015) Alessandra Biffi   Cell Stem Cell

Genome engineering in cattle: recent technological advancements

(2015) Zhongde Wang   CHROMOSOME RESEARCH

Advances in genetic modification of farm animals using zinc-finger nucleases (ZFN)

(2015) Bjoern Petersen et al.   CHROMOSOME RESEARCH

CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells

(2015) Rowan Flynn et al.   EXPERIMENTAL HEMATOLOGY

Engineering large animal models of human disease

(2015) C Bruce A Whitelaw et al.   JOURNAL OF PATHOLOGY

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

(2015) Benjamin P. Kleinstiver et al.   NATURE

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR–Cas9-mediated mutagenesis

(2015) Davide Seruggia et al.   NUCLEIC ACIDS RESEARCH

Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes

(2015) M. Crispo et al.   PLoS One

TALE nickase-mediatedSP110knockin endows cattle with increased resistance to tuberculosis

(2015) Haibo Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

(2015) C. E. Nelson et al.   SCIENCE

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs

(2015) Lili Qian et al.   Scientific Reports

Production of Human Albumin in Pigs Through CRISPR/Cas9-Mediated Knockin of Human cDNA into Swine Albumin Locus in the Zygotes

(2015) Jin Peng et al.   Scientific Reports

Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system

(2015) Xiaolong Wang et al.   Scientific Reports

Efficient introgression of allelic variants by embryo-mediated editing of the bovine genome

(2015) Jingwei Wei et al.   Scientific Reports

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

(2015) Puping Liang et al.   Protein & Cell

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

(2015) Zita Garate et al.   Stem Cell Reports

Large Genomic Fragment Deletions and Insertions in Mouse Using CRISPR/Cas9

(2015) Luqing Zhang et al.   PLoS One

Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk

(2015) Chenchen Cui et al.   Scientific Reports

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys

(2014) Hailiang Liu et al.   Cell Stem Cell

TALEN-Mediated Generation and Genetic Correction of Disease-Specific Human Induced Pluripotent Stem Cells

(2014) Sivaprakash Ramalingam et al.   CURRENT GENE THERAPY

Generation ofeGFPandCreknockin rats by CRISPR/Cas9

(2014) Yuanwu Ma et al.   FEBS Journal

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

(2014) Danilo Maddalo et al.   NATURE

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Meganuclease I-SceI Containing Nuclear Localization Signal (NLS-I-SceI) Efficiently Mediated Mammalian Germline Transgenesis via Embryo Cytoplasmic Microinjection

(2014) Yong Wang et al.   PLoS One

Efficient Gene Knockout in Goats Using CRISPR/Cas9 System

(2014) Wei Ni et al.   PLoS One

Generation of mastitis resistance in cows by targeting human lysozyme gene to  -casein locus using zinc-finger nucleases

(2014) X. Liu et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The new CRISPR–Cas system: RNA-guided genome engineering to efficiently produce any desired genetic alteration in animals

(2014) Davide Seruggia et al.   TRANSGENIC RESEARCH

Genome edited sheep and cattle

(2014) Chris Proudfoot et al.   TRANSGENIC RESEARCH

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Highly Efficient Targeted Mutagenesis in Mice Using TALENs

(2013) Sudeepta Kumar Panda et al.   GENETICS

Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5

(2013) Dawn A. Maier et al.   HUMAN GENE THERAPY

TALEN-based Gene Correction for Epidermolysis Bullosa

(2013) Mark J Osborn et al.   MOLECULAR THERAPY

TALEN-mediated editing of the mouse Y chromosome

(2013) Haoyi Wang et al.   NATURE BIOTECHNOLOGY

Knockout mice created by TALEN-mediated gene targeting

(2013) Young Hoon Sung et al.   NATURE BIOTECHNOLOGY

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA

(2013) Benedikt Wefers et al.   Nature Protocols

Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish

(2013) An Xiao et al.   NUCLEIC ACIDS RESEARCH

Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs

(2013) Jige Xin et al.   PLoS One

Efficient nonmeiotic allele introgression in livestock using custom endonucleases

(2013) W. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs

(2013) Deug-Nam Kwon et al.   Scientific Reports

Structural basis of the TAL effector–DNA interaction

(2012) Matthias Bochtler   BIOLOGICAL CHEMISTRY

TALE nucleases: tailored genome engineering made easy

(2012) Claudio Mussolino et al.   CURRENT OPINION IN BIOTECHNOLOGY

Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases

(2012) Séverine Ménoret et al.   FASEB JOURNAL

Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs

(2012) B L Ellis et al.   GENE THERAPY

I-SceI-Mediated Double-Strand Break Does Not Increase the Frequency of Homologous Recombination at the Dct Locus in Mouse Embryonic Stem Cells

(2012) Myriam Fenina et al.   PLoS One

Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos

(2012) Mario Hermann et al.   PLoS One

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

(2012) G. Gasiunas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient TALEN-mediated gene knockout in livestock

(2012) D. F. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle

(2011) Shengli Yu et al.   CELL RESEARCH

Knockout rats generated by embryo microinjection of TALENs

(2011) Laurent Tesson et al.   NATURE BIOTECHNOLOGY

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Genome Modification in Mice Using Zinc-Finger Nucleases

(2010) I. D. Carbery et al.   GENETICS

Zinc-finger Nuclease-induced Gene Repair With Oligodeoxynucleotides: Wanted and Unwanted Target Locus Modifications

(2010) Sarah Radecke et al.   MOLECULAR THERAPY

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

(2010) M. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

(2009) Sylvestre Grizot et al.   NUCLEIC ACIDS RESEARCH

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Zinc-finger nucleases: a powerful tool for genetic engineering of animals

(2009) Séverine Rémy et al.   TRANSGENIC RESEARCH

Capture of Authentic Embryonic Stem Cells from Rat Blastocysts

(2008) Mia Buehr et al.   CELL