Assembly of RNA polymerase II transcription initiation complexes

Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II

(2022) Chun Yang et al.   MOLECULAR CELL

Mediator structure and conformation change

(2021) Heqiao Zhang et al.   MOLECULAR CELL

Structure of the human Mediator-bound transcription preinitiation complex

(2021) R. Abdella et al.   SCIENCE

Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core

(2021) Haiyan Zhao et al.   Nature Communications

Structures of mammalian RNA polymerase II pre-initiation complexes

(2021) Shintaro Aibara et al.   NATURE

Structure of the human Mediator–RNA polymerase II pre-initiation complex

(2021) Srinivasan Rengachari et al.   NATURE

Structures of the human Mediator and Mediator-bound preinitiation complex

(2021) Xizi Chen et al.   SCIENCE

Structure of RNA polymerase II pre-initiation complex at 2.9 Å defines initial DNA opening

(2021) Sandra Schilbach et al.   CELL

Structure of the human SAGA coactivator complex

(2021) Dominik A. Herbst et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of SAGA and mechanism of TBP deposition on gene promoters

(2020) Gabor Papai et al.   NATURE

Structure of the transcription coactivator SAGA

(2020) Haibo Wang et al.   NATURE

Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA

(2020) Rafal Donczew et al.   eLife

Structure and mechanism of the RNA polymerase II transcription machinery

(2020) Allison C. Schier et al.   GENES & DEVELOPMENT

In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair

(2020) Stefan Peissert et al.   Nature Communications

Twenty years of Mediator complex structural studies

(2019) Alexis Verger et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

(2019) Laila El Khattabi et al.   CELL

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Promoter Distortion and Opening in the RNA Polymerase II Cleft

(2018) Christian Dienemann et al.   MOLECULAR CELL

Structure of human TFIID and mechanism of TBP loading onto promoter DNA

(2018) Avinash B. Patel et al.   SCIENCE

Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression

(2017) Sergey Alekseev et al.   MOLECULAR CELL

Structures of transcription pre-initiation complex with TFIIH and Mediator

(2017) S. Schilbach et al.   NATURE

Core Mediator structure at 3.4 Å extends model of transcription initiation complex

(2017) Kayo Nozawa et al.   NATURE

The cryo-electron microscopy structure of human transcription factor IIH

(2017) Basil J. Greber et al.   NATURE

Paused RNA polymerase II inhibits new transcriptional initiation

(2017) Wanqing Shao et al.   NATURE GENETICS

CDK9-dependent RNA polymerase II pausing controls transcription initiation

(2017) Saskia Gressel et al.   eLife

Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex

(2016) Philip J. Robinson et al.   CELL

Mediator Architecture and RNA Polymerase II Interaction

(2016) Clemens Plaschka et al.   JOURNAL OF MOLECULAR BIOLOGY

Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo

(2016) Célia Jeronimo et al.   MOLECULAR CELL

Near-atomic resolution visualization of human transcription promoter opening

(2016) Yuan He et al.   NATURE

Transcription initiation complex structures elucidate DNA opening

(2016) C. Plaschka et al.   NATURE

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly

(2016) Robert K. Louder et al.   NATURE

Regulatory Enhancer–Core-Promoter Communication via Transcription Factors and Cofactors

(2016) Muhammad A. Zabidi et al.   TRENDS IN GENETICS

Architecture of the RNA polymerase II–Mediator core initiation complex

(2015) C. Plaschka et al.   NATURE

Structural basis of transcription initiation by RNA polymerase II

(2015) Sarah Sainsbury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation

(2015) James Fishburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex

(2014) Kuang-Lei Tsai et al.   CELL

TFIIH Phosphorylation of the Pol II CTD Stimulates Mediator Dissociation from the Preinitiation Complex and Promoter Escape

(2014) Koon Ho Wong et al.   MOLECULAR CELL

In TFIIH, XPD Helicase Is Exclusively Devoted to DNA Repair

(2014) Jochen Kuper et al.   PLOS BIOLOGY

Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State

(2013) Michael A. Cianfrocco et al.   CELL

The Mediator complex and transcription regulation

(2013) Zachary C. Poss et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structural visualization of key steps in human transcription initiation

(2013) Yuan He et al.   NATURE

Structure of the Mediator head module

(2012) Laurent Larivière et al.   NATURE

Genome-wide structure and organization of eukaryotic pre-initiation complexes

(2012) Ho Sung Rhee et al.   NATURE

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

(2011) Hidehisa Takahashi et al.   CELL