Structure of the human SAGA coactivator complex

Structural insights into preinitiation complex assembly on core promoters

(2021) Xizi Chen et al.   SCIENCE

3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM

(2021) Ali Punjani et al.   JOURNAL OF STRUCTURAL BIOLOGY

The SF3b complex: splicing and beyond

(2020) Chengfu Sun   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure of SAGA and mechanism of TBP deposition on gene promoters

(2020) Gabor Papai et al.   NATURE

Structure of the transcription coactivator SAGA

(2020) Haibo Wang et al.   NATURE

SAGA and TFIID: Friends of TBP drifting apart

(2020) H.Th. Marc Timmers   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Dynamic modules of the coactivator SAGA in eukaryotic transcription

(2020) Youngseo Cheon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Characterization of a metazoan ADA acetyltransferase complex

(2019) Jelly H M Soffers et al.   NUCLEIC ACIDS RESEARCH

Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability

(2019) Benjamin Cogné et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID

(2019) Simona V. Antonova et al.   GENES & DEVELOPMENT

Software tools for automated transmission electron microscopy

(2019) Martin Schorb et al.   NATURE METHODS

Multiple direct interactions of TBP with the MYC oncoprotein

(2019) Yong Wei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast

(2019) Alberto Elías-Villalobos et al.   Nature Communications

InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1–SMG8–SMG9 complex

(2019) Yair Gat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex

(2019) Edmond J. Feris et al.   PLoS One

Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly

(2018) Simona V. Antonova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of human TFIID and mechanism of TBP loading onto promoter DNA

(2018) Avinash B. Patel et al.   SCIENCE

Molecular structure of promoter-bound yeast TFIID

(2018) Olga Kolesnikova et al.   Nature Communications

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development

(2017) Xuanying Li et al.   GENES & DEVELOPMENT

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Sharing the SAGA

(2017) Dominique Helmlinger et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA

(2017) Grigory Sharov et al.   Nature Communications

Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

(2017) Luis Miguel Díaz-Santín et al.   eLife

CTCF and cohesin regulate chromatin loop stability with distinct dynamics

(2017) Anders S Hansen et al.   eLife

Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer

(2016) Ji Wang et al.   Journal of Breast Cancer

The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing

(2016) Rachel Stegeman et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

(2016) Constantin Cretu et al.   MOLECULAR CELL

Conformational Flexibility and Subunit Arrangement of the Modular Yeast Spt-Ada-Gcn5 Acetyltransferase Complex

(2015) Dheva Setiaputra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Day of the dead: pseudokinases and pseudophosphatases in physiology and disease

(2014) Veronika Reiterer et al.   TRENDS IN CELL BIOLOGY

Functions of SAGA in development and disease

(2014) Li Wang et al.   Epigenomics

Core promoter factor TAF9B regulates neuronal gene expression

(2014) Francisco J Herrera et al.   eLife

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Metazoan promoters: emerging characteristics and insights into transcriptional regulation

(2012) Boris Lenhard et al.   NATURE REVIEWS GENETICS

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure and in Vivo Requirement of the Yeast Spt6 SH2 Domain

(2009) Stefan Dengl et al.   JOURNAL OF MOLECULAR BIOLOGY

Refinement of Protein Structures into Low-Resolution Density Maps Using Rosetta

(2009) Frank DiMaio et al.   JOURNAL OF MOLECULAR BIOLOGY

The Human SPT20-Containing SAGA Complex Plays a Direct Role in the Regulation of Endoplasmic Reticulum Stress-Induced Genes

(2008) Z. Nagy et al.   MOLECULAR AND CELLULAR BIOLOGY