Recent Advances in Modified Cap Analogs: Synthesis, Biochemical Properties, and mRNA Based Vaccines

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

(2021) Marcin Warminski et al.   ACS Chemical Biology

Tricks and threats of RNA viruses – towards understanding the fate of viral RNA

(2021) Lukasz Markiewicz et al.   RNA Biology

Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications

(2021) Annamalai Senthilvelan et al.   ORGANIC LETTERS

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

(2021) Renata Kasprzyk et al.   ANTIVIRAL RESEARCH

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

Chemistry of Lipid Nanoparticles for RNA Delivery

(2021) Yulia Eygeris et al.   ACCOUNTS OF CHEMICAL RESEARCH

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

(2020) Pawel J Sikorski et al.   NUCLEIC ACIDS RESEARCH

Effect of HIV-1 TAT Peptide Fusion on 5′ mRNA Cap Analogs Cell Membrane Permeability and Translation Inhibition

(2020) Karolina Piecyk et al.   BIOCONJUGATE CHEMISTRY

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

(2019) Giulietta Maruggi et al.   MOLECULAR THERAPY

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins

(2019) Michal Kopcial et al.   MOLECULES

Modified ARCA analogs providing enhanced translational properties of capped mRNAs

(2018) Ilona Kocmik et al.   CELL CYCLE

5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes

(2018) Blazej A. Wojtczak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators

(2018) Sylwia Walczak et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

(2018) Agnieszka Mlynarska-Cieslak et al.   ORGANIC LETTERS

mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes

(2018) Sylwia Bednarek et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Synthesis of the first double-functionalized dinucleotide mRNA cap analogue for its specific labeling

(2017) Karolina Piecyk et al.   TETRAHEDRON LETTERS

A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry

(2017) Sylwia Walczak et al.   Chemical Science

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps

(2017) Marcin Warminski et al.   Topics in Current Chemistry

Design, synthesis and biological evaluation of dinucleotide mRNA cap analog containing propargyl moiety

(2016) Muthian Shanmugasundaram et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cap-like structures in bacterial RNA and epitranscriptomic modification

(2016) Andres Jäschke et al.   CURRENT OPINION IN MICROBIOLOGY

mRNA capping: biological functions and applications

(2016) Anand Ramanathan et al.   NUCLEIC ACIDS RESEARCH

NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs

(2014) Hana Cahová et al.   NATURE

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

(2014) Joanna Kowalska et al.   NUCLEIC ACIDS RESEARCH

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

(2012) Anna M. Rydzik et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cap-Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target

(2012) Yan Jia et al.   MEDICINAL RESEARCH REVIEWS

Synthesis and evaluation of 2′-O-allyl substituted dinucleotide cap analog for mRNA translation

(2010) Anilkumar R. Kore et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Locked Nucleic Acids: Promising Nucleic Acid Analogs for Therapeutic Applications

(2010) Rakesh N. Veedu et al.   CHEMISTRY & BIODIVERSITY

Organic Synthesis and Improved Biological Properties of Modified mRNA Cap Analogs

(2010) Anilkumar R. Kore et al.   CURRENT ORGANIC CHEMISTRY

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

(2010) A N Kuhn et al.   GENE THERAPY

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

(2010) Jacek Jemielity et al.   NEW JOURNAL OF CHEMISTRY

Cap and cap-binding proteins in the control of gene expression

(2010) Ivan Topisirovic et al.   Wiley Interdisciplinary Reviews-RNA

Enzymology of RNA cap synthesis

(2010) Agnidipta Ghosh et al.   Wiley Interdisciplinary Reviews-RNA

Synthesis and Application of 2′-ara-Fluoroguanosine-substituted Cap Analog

(2009) Anilkumar R. Kore et al.   CHEMISTRY LETTERS

Locked Nucleic Acid (LNA)-Modified Dinucleotide mRNA Cap Analogue: Synthesis, Enzymatic Incorporation, and Utilization

(2009) Anilkumar R. Kore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Synthesis of New Cap Analogs Containing 2-OH Modifications on Both Guanosine and m7Guanosine Moieties

(2009) Anilkumar Kore et al.   LETTERS IN ORGANIC CHEMISTRY

Synthesis and application of a new 2′,3′-isopropylidene guanosine substituted cap analog

(2008) Anilkumar R. Kore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of trimethyl-substituted cap analogs

(2008) Anilkumar R. Kore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion

(2008) Irina Y Tcherepanova et al.   BMC MOLECULAR BIOLOGY

Current prospects for mRNA gene delivery

(2008) Ayako Yamamoto et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Recent Developments in 5‘-Terminal Cap Analogs: Synthesis and Biological Ramifications.

(2008) Anilkumar Kore et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY