Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity

(2021) Sheng Lin et al.   NUCLEIC ACIDS RESEARCH

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

(2020) Petra Krafcikova et al.   Nature Communications

SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts

(2020) Ting Shu et al.   VIROLOGICA SINICA

Targeting RNA G‐quadruplex in SARS‐CoV‐2: A Promising Therapeutic Target for COVID‐19?

(2020) Xiaogang Qu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

(2020) Zachary A. Gurard-Levin et al.   ANTIVIRAL RESEARCH

Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

(2020) Rostom Ahmed-Belkacem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

(2020) Tarek Mohamed Abd El-Aziz et al.   INFECTION GENETICS AND EVOLUTION

Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2

(2020) William R. Martin et al.   JOURNAL OF PROTEOME RESEARCH

SARS-CoV-2 vaccines in development

(2020) Florian Krammer   NATURE

Inhibition of SARS-CoV 3CL protease by flavonoids

(2019) Seri Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response

(2016) Martina Becares et al.   JOURNAL OF VIROLOGY

mRNA capping: biological functions and applications

(2016) Anand Ramanathan et al.   NUCLEIC ACIDS RESEARCH

The Rabies Virus L Protein Catalyzes mRNA Capping with GDP Polyribonucleotidyltransferase Activity

(2016) Minako Ogino et al.   Viruses-Basel

Molecular mechanisms of coronavirus RNA capping and methylation

(2016) Yu Chen et al.   VIROLOGICA SINICA

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

(2016) L. Delang et al.   Scientific Reports

The dengue virus NS5 protein as a target for drug discovery

(2015) Siew Pheng Lim et al.   ANTIVIRAL RESEARCH

Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

(2015) Yuanyuan Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

(2014) Bruno Coutard et al.   ANTIVIRAL RESEARCH

Correction: In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

(2014) Mickaël Bouvet et al.   PLoS Pathogens

The viral RNA capping machinery as a target for antiviral drugs

(2012) François Ferron et al.   ANTIVIRAL RESEARCH

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

(2012) M. Bouvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4 Agonists and Antagonists

(2011) Fabien Vincent et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Conventional and unconventional mechanisms for capping viral mRNA

(2011) Etienne Decroly et al.   NATURE REVIEWS MICROBIOLOGY

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

(2011) Etienne Decroly et al.   PLoS Pathogens

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

(2010) Lance D. Eckerle et al.   PLoS Pathogens

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flavivirus methyltransferase: A novel antiviral target

(2008) Hongping Dong et al.   ANTIVIRAL RESEARCH