Trafficking and retention of protein antigens across systems and immune cell types

Dendritic Cells Revisited

(2021) Mar Cabeza-Cabrerizo et al.   Annual Review of Immunology

Evolution of antibody immunity to SARS-CoV-2

(2021) Christian Gaebler et al.   NATURE

Rate of Immune Complex Cycling in Follicular Dendritic Cells Determines the Extent of Protecting Antigen Integrity and Availability to Germinal Center B Cells

(2021) Theinmozhi Arulraj et al.   JOURNAL OF IMMUNOLOGY

Marginal zone B cells: From housekeeping function to autoimmunity?

(2021) Anna-Karin E. Palm et al.   JOURNAL OF AUTOIMMUNITY

Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node

(2021) Shannon M Walsh et al.   eLife

Contributions of PD‐L1 reverse signaling to dendritic cell trafficking

(2021) Beth Ann Jirón Tamburini   FEBS Journal

Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells

(2021) Balthasar A. Heesters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

(2021) Sandra Lopez-Leon et al.   Scientific Reports

MARCO + lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination

(2021) Kathryn S Carpentier et al.   EMBO JOURNAL

Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

(2020) Efthymia Vokali et al.   Nature Communications

Emerging Roles for Lymphatics in Chronic Liver Disease

(2020) Matthew A. Burchill et al.   Frontiers in Physiology

Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes

(2020) Noriki Fujimoto et al.   PLOS BIOLOGY

Prolonged presence of SARS-CoV-2 viral RNA in faecal samples

(2020) Yongjian Wu et al.   Lancet Gastroenterology & Hepatology

Development of Hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

(2020) Xiaohua Liu et al.   Acta Pharmaceutica Sinica B

A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature

(2020) Menglan Xiang et al.   Frontiers in Cardiovascular Medicine

Human γδ T cells recognize CD1b by two distinct mechanisms

(2020) Josephine F. Reijneveld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Markers of neutrophil activation and extracellular traps formation are predictive of appendicitis in mice and humans: a pilot study

(2020) Michael Boettcher et al.   Scientific Reports

PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

(2020) Erin D. Lucas et al.   Cell Reports

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection

(2019) Christopher M. Harpur et al.   JOURNAL OF IMMUNOLOGY

Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages

(2019) Sang Heon Suh et al.   EMBO REPORTS

Fibroblastic reticular cells at the nexus of innate and adaptive immune responses

(2019) Christian Perez‐Shibayama et al.   IMMUNOLOGICAL REVIEWS

Mucosal vaccines and technology

(2019) A. Miquel‐Clopés et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells

(2019) Beth A. Jiron Tamburini et al.   Frontiers in Immunology

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils

(2019) Akira Takeda et al.   IMMUNITY

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

(2019) Chrysothemis C. Brown et al.   CELL

Splenic Red Pulp Macrophages Cross-Prime Early Effector CTL That Provide Rapid Defense against Viral Infections

(2019) Marika Enders et al.   JOURNAL OF IMMUNOLOGY

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

Recent progress in understanding HIV reservoirs

(2018) Hsiao-Hsuan Kuo et al.   Current Opinion in HIV and AIDS

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8 + T Cell Cross-Priming

(2018) Dieke van Dinther et al.   Cell Reports

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

(2018) Carlos Rosales   Frontiers in Physiology

Human Langerhans Cells with Pro-inflammatory Features Relocate within Psoriasis Lesions

(2018) Liv Eidsmo et al.   Frontiers in Immunology

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Lacteal junction zippering protects against diet-induced obesity

(2018) Feng Zhang et al.   SCIENCE

Marginal-Zone B-Cells Are Main Producers of IgM in Humans, and Are Reduced in Patients With Autoimmune Vasculitis

(2018) Daniel Appelgren et al.   Frontiers in Immunology

Dendritic cell and antigen dispersal landscapes regulate T cell immunity

(2017) Michael Y. Gerner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal lymphatic vasculature: structure, mechanisms and functions

(2017) Jeremiah Bernier-Latmani et al.   Nature Reviews Gastroenterology & Hepatology

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine

(2017) C. C. Bain et al.   Nature Communications

Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction

(2017) Ross M. Kedl et al.   Nature Communications

Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation

(2017) Samantha Arokiasamy et al.   Scientific Reports

Lymphatic Vessels Balance Viral Dissemination and Immune Activation following Cutaneous Viral Infection

(2017) Christopher P. Loo et al.   Cell Reports

HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

(2017) Paul Castellano et al.   Scientific Reports

Siglec-F is a novel intestinal M cell marker

(2016) Nadezhda Gicheva et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functions of Murine Dendritic Cells

(2016) Vivek Durai et al.   IMMUNITY

Glymphatic clearance controls state-dependent changes in brain lactate concentration

(2016) Iben Lundgaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

(2016) Amanda W. Lund et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

(2016) Stephanie Gras et al.   Nature Communications

Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

(2016) Samuele Calabro et al.   Cell Reports

Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium

(2015) Ross M. Kedl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Strategically Localized Dendritic Cells Promote Rapid T Cell Responses to Lymph-Borne Particulate Antigens

(2015) Michael Y. Gerner et al.   IMMUNITY

Human skin dendritic cells in health and disease

(2015) Muzlifah Haniffa et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Colonic tolerance develops in the iliac lymph nodes and can be established independent of CD103+ dendritic cells

(2015) S Veenbergen et al.   Mucosal Immunology

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes

(2015) Henry R. Hampton et al.   Nature Communications

Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes

(2015) Balthasar A. Heesters et al.   PLoS Pathogens

Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses

(2015) Björn E. Clausen et al.   Frontiers in Immunology

Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers

(2015) Ai-Sheng Ho et al.   Oncotarget

Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+T cell tolerance

(2014) Juan Dubrot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fibroblastic Reticular Cells Guide T Lymphocyte Entry into and Migration within the Splenic T Cell Zone

(2014) M. Bajenoff et al.   JOURNAL OF IMMUNOLOGY

Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103- Pulmonary Dendritic Cell Populations

(2014) C. Jakubzick et al.   JOURNAL OF IMMUNOLOGY

Prolonged Antigen Presentation following an Acute Virus Infection Requires Direct and Then Cross-Presentation

(2014) Erica L. Heipertz et al.   JOURNAL OF IMMUNOLOGY

Steady-State Antigen Scavenging, Cross-Presentation, and CD8+ T Cell Priming: A New Role for Lymphatic Endothelial Cells

(2014) S. Hirosue et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Exhibit Differential Requirements for Homing Molecules in Their Lymphatic and Blood Trafficking into Draining Lymph Nodes

(2014) Carolina V. Gorlino et al.   JOURNAL OF IMMUNOLOGY

Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells

(2014) V Cerovic et al.   Mucosal Immunology

CD11b+ Migratory Dendritic Cells Mediate CD8 T Cell Cross-Priming and Cutaneous Imprinting after Topical Immunization

(2014) Suzanne T. Nizza et al.   PLoS One

Mapping the Distinctive Populations of Lymphatic Endothelial Cells in Different Zones of Human Lymph Nodes

(2014) Saem Mul Park et al.   PLoS One

Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction

(2014) A Nicole Desch et al.   Nature Communications

Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection

(2014) Beth A. Tamburini et al.   Nature Communications

Roles of M cells in infection and mucosal vaccines

(2014) Miao Wang et al.   Human Vaccines & Immunotherapeutics

B1b Cells Recognize Protective Antigens after Natural Infection and Vaccination

(2014) Adam F. Cunningham et al.   Frontiers in Immunology

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Antigen Binding and Activation

(2013) Balthasar A. Heesters et al.   IMMUNITY

IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation

(2013) Emma K. Persson et al.   IMMUNITY

CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity

(2013) Yosuke Kumamoto et al.   IMMUNITY

Langerin + Dermal DC, but Not Langerhans Cells, Are Required for Effective CD8-Mediated Immune Responses after Skin Scarification with Vaccinia Virus

(2013) Julien Seneschal et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Plasmacytoid Dendritic Cells Transport Peripheral Antigens to the Thymus to Promote Central Tolerance

(2012) Husein Hadeiba et al.   IMMUNITY

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo

(2012) M. R. Gaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of  -Amyloid in Mice with Alzheimer's Disease Pathology

(2012) J. H. Roh et al.   Science Translational Medicine

Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3

(2012) Linda Yip et al.   Journal of Molecular Cell Biology

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Stromal Cell–Immune Cell Interactions

(2011) Ramon Roozendaal et al.   Annual Review of Immunology

TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway

(2011) J. Z. Oh et al.   BLOOD

M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery

(2011) Sae-Hae Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Peyer's Patch Dendritic Cells Sample Antigens by Extending Dendrites Through M Cell-Specific Transcellular Pores

(2011) Hugues Lelouard et al.   GASTROENTEROLOGY

Chemokines control naive CD8+T cell selection of optimal lymph node antigen presenting cells

(2011) Heather D. Hickman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD103+pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

(2011) A. Nicole Desch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Airway Antigen Sampling System: Respiratory M Cells as an Alternative Gateway for Inhaled Antigens

(2011) Dong-Young Kim et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

(2011) Christine Moussion et al.   NATURE

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

T cell responses during influenza infection: getting and keeping control

(2011) Taeg S. Kim et al.   TRENDS IN IMMUNOLOGY

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α

(2010) Ana Rouzaut et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Origin and development of dendritic cells

(2010) Kang Liu et al.   IMMUNOLOGICAL REVIEWS

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Acquisition and presentation of follicular dendritic cell–bound antigen by lymph node–resident dendritic cells

(2010) Megan L. McCloskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection

(2010) Taeg S. Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The route of priming influences the ability of respiratory virus–specific memory CD8+T cells to be activated by residual antigen

(2010) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

(2010) Anne L. Fletcher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Capacity To Induce Cross-Presentation Dictates the Success of a TLR7 Agonist-Conjugate Vaccine for Eliciting Cellular Immunity

(2010) J. Z. Oh et al.   JOURNAL OF IMMUNOLOGY

The M Cell-Targeting Ligand Promotes Antigen Delivery and Induces Antigen-Specific Immune Responses in Mucosal Vaccination

(2010) S.-H. Kim et al.   JOURNAL OF IMMUNOLOGY

Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

(2010) Matteo Iannacone et al.   NATURE

CD169+ macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes

(2010) Patricia Barral et al.   NATURE IMMUNOLOGY

Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell–mediated immunity

(2010) Luzheng Liu et al.   NATURE MEDICINE

Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells

(2010) Ali Azizi et al.   PLoS Pathogens

B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells

(2009) M. Bajenoff et al.   BLOOD

Dendritic Cell Antigen Presentation Drives Simultaneous Cytokine Production by Effector and Regulatory T Cells in Inflamed Skin

(2009) James B. McLachlan et al.   IMMUNITY

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

(2009) Ramon Roozendaal et al.   IMMUNITY

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

Visualizing B cell capture of cognate antigen from follicular dendritic cells

(2009) Kazuhiro Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Virus-like Particle (VLP) Lymphatic Trafficking and Immune Response Generation After Immunization by Different Routes

(2009) Rafael Cubas et al.   JOURNAL OF IMMUNOTHERAPY

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

(2009) Linda Yip et al.   NATURE IMMUNOLOGY

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

(2009) N. van Montfoort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

(2008) Babacar Cisse et al.   CELL

Endocytosis mechanisms and the cell biology of antigen presentation

(2008) Sven Burgdorf et al.   CURRENT OPINION IN IMMUNOLOGY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A two-step model for Langerhans cell migration to skin-draining LN

(2008) Eduardo J. Villablanca et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells Mediate Oral Tolerance

(2008) Anne Goubier et al.   IMMUNITY

The conduit system of the lymph node

(2008) R. Roozendaal et al.   INTERNATIONAL IMMUNOLOGY

Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

(2008) Louise J Young et al.   NATURE IMMUNOLOGY

Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

(2008) Heather D Hickman et al.   NATURE IMMUNOLOGY

Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function

(2008) Christopher D.C. Allen et al.   SEMINARS IN IMMUNOLOGY

Vaccination and antigenic drift in influenza

(2008) Maciej F. Boni   VACCINE

Antigen presentation by monocytes and monocyte-derived cells

(2007) Gwendalyn J Randolph et al.   CURRENT OPINION IN IMMUNOLOGY