Fibroblastic reticular cells at the nexus of innate and adaptive immune responses

Single-Cell Transcriptomics Meets Lineage Tracing

(2018) Lennart Kester et al.   Cell Stem Cell

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

(2018) Yang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

(2018) Ayano C. Kohlgruber et al.   NATURE IMMUNOLOGY

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

(2018) Hsin-Ying Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A short field guide to fibroblast function in immunity

(2018) Matthew B. Buechler et al.   SEMINARS IN IMMUNOLOGY

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

(2018) James Kinchen et al.   CELL

A Fresh View on Lymph Node Organogenesis

(2018) Lucas Onder et al.   TRENDS IN IMMUNOLOGY

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

(2018) Joern Pezoldt et al.   Nature Communications

The conduit system exports locally secreted IgM from lymph nodes

(2018) Guilhem R. Thierry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peyer’s patch myeloid cells infection by Listeria signals through gp38+ stromal cells and locks intestinal villus invasion

(2018) Olivier Disson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node

(2018) Arata Takeuchi et al.   Frontiers in Immunology

Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses

(2017) Abhishek Das et al.   IMMUNITY

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis

(2017) Lucas Onder et al.   IMMUNITY

Dendritic cell and antigen dispersal landscapes regulate T cell immunity

(2017) Michael Y. Gerner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy

(2017) Sandra M. Kallert et al.   Nature Communications

Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

(2017) Julia L. Gregory et al.   Cell Reports

Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells

(2017) Karin Schaeuble et al.   Cell Reports

Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone

(2017) Mohamed Habbeddine et al.   Cell Reports

Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

(2017) Florian Posch et al.   OncoImmunology

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation

(2016) Etsushi Kuroda et al.   IMMUNITY

Innate lymphoid cell regulation of adaptive immunity

(2016) David R. Withers   IMMUNOLOGY

Cutting Edge: LL-37–Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer’s Patch Germinal Centers

(2016) Sae-Hae Kim et al.   JOURNAL OF IMMUNOLOGY

Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs

(2016) Cristina Gil-Cruz et al.   NATURE IMMUNOLOGY

Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL

(2016) Olga G. Cordeiro et al.   PLoS One

Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules

(2016) Konrad Buscher et al.   Nature Communications

Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation

(2016) Lucy H. Jackson-Jones et al.   Nature Communications

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality

(2016) Mario Novkovic et al.   PLOS BIOLOGY

Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus

(2016) Helen E. Farrell et al.   PLoS Pathogens

Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility

(2016) Akira Takeda et al.   eLife

Fat-Associated Lymphoid Clusters in Inflammation and Immunity

(2016) Sara Cruz-Migoni et al.   Frontiers in Immunology

A Reproducible Method for Isolation and In Vitro Culture of Functional Human Lymphoid Stromal Cells from Tonsils

(2016) Yotam E. Bar-Ephraim et al.   PLoS One

CollagenVI-Cre mice: A new tool to target stromal cells in secondary lymphoid organs

(2016) Alejandro Prados et al.   Scientific Reports

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

(2015) Christopher D. Buckley et al.   Annual Review of Immunology

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

(2015) Natalia B. Pikor et al.   IMMUNITY

Phenotypic and Morphological Properties of Germinal Center Dark ZoneCxcl12-Expressing Reticular Cells

(2015) Lauren B. Rodda et al.   JOURNAL OF IMMUNOLOGY

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

Inflammation-induced formation of fat-associated lymphoid clusters

(2015) Cécile Bénézech et al.   NATURE IMMUNOLOGY

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

(2015) Francesca Barone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection

(2015) M. Gaya et al.   SCIENCE

Stromal infrastructure of the lymph node and coordination of immunity

(2015) Jonathan E. Chang et al.   TRENDS IN IMMUNOLOGY

CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

(2015) Emma C. Mackley et al.   Nature Communications

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

(2014) Nicolas Fasnacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17–induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs

(2014) Henrike Fleige et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs

(2014) T. Katakai et al.   JOURNAL OF IMMUNOLOGY

CXCL13, CCL21, and CXCL12 Expression in Salivary Glands of Patients with Sjogren's Syndrome and MALT Lymphoma: Association with Reactive and Malignant Areas of Lymphoid Organization

(2014) F. Barone et al.   JOURNAL OF IMMUNOLOGY

Differential Molecular and Anatomical Basis for B Cell Migration into the Peritoneal Cavity and Omental Milky Spots

(2014) S. Berberich et al.   JOURNAL OF IMMUNOLOGY

The development and function of mucosal lymphoid tissues: a balancing act with micro-organisms

(2014) T D Randall et al.   Mucosal Immunology

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

(2014) Viviana Cremasco et al.   NATURE IMMUNOLOGY

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

(2014) Giuliana Magri et al.   NATURE IMMUNOLOGY

Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo

(2014) Guangwei Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage

(2013) M. Iolyeva et al.   BLOOD

Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation

(2013) Satoshi Nishimura et al.   Cell Metabolism

Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity

(2013) Qian Chai et al.   IMMUNITY

High Endothelial Venule Blood Vessels for Tumor-Infiltrating Lymphocytes Are Associated with Lymphotoxin  -Producing Dendritic Cells in Human Breast Cancer

(2013) L. Martinet et al.   JOURNAL OF IMMUNOLOGY

Follicular dendritic cells: origin, phenotype, and function in health and disease

(2013) Adriano Aguzzi et al.   TRENDS IN IMMUNOLOGY

IL-7-producing stromal cells are critical for lymph node remodeling

(2012) L. Onder et al.   BLOOD

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

(2012) Nike Julia Krautler et al.   CELL

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

(2012) Sophie E. Acton et al.   IMMUNITY

Natural IgM Mediates Complement-Dependent Uptake of Francisella tularensis by Human Neutrophils via Complement Receptors 1 and 3 in Nonimmune Serum

(2012) J. T. Schwartz et al.   JOURNAL OF IMMUNOLOGY

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Characterization of Omental Immune Aggregates during Establishment of a Latent Gammaherpesvirus Infection

(2012) Kathleen S. Gray et al.   PLoS One

Tertiary lymphoid organs in infection and autoimmunity

(2012) Katrijn Neyt et al.   TRENDS IN IMMUNOLOGY

High endothelial venules (HEVs) in human melanoma lesions

(2012) Ludovic Martinet et al.   OncoImmunology

Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers

(2011) Xiaoming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

(2011) Veronika Lukacs-Kornek et al.   NATURE IMMUNOLOGY

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

(2011) Nadine Honke et al.   NATURE IMMUNOLOGY

Disrupted Lymph Node and Splenic Stroma in Mice with Induced Inflammatory Melanomas Is Associated with Impaired Recruitment of T and Dendritic Cells

(2011) Saïdi M. Soudja et al.   PLoS One

Fibroblastic Reticular Cells From Lymph Nodes Attenuate T Cell Expansion by Producing Nitric Oxide

(2011) Stefanie Siegert et al.   PLoS One

Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs

(2010) A. V. Tumanov et al.   BLOOD

Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation

(2010) Alexandre Garin et al.   IMMUNITY

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

(2010) Clémentine Schilte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

(2009) Javier Rangel-Moreno et al.   IMMUNITY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

Development of Secondary Lymphoid Organs

(2008) Troy D. Randall et al.   Annual Review of Immunology

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue–inducer cells with stroma of the T cell zone

(2008) Elke Scandella et al.   NATURE IMMUNOLOGY