A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature

Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche

(2019) Isabelle Mondor et al.   IMMUNITY

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

(2019) Ruili Huang et al.   Frontiers in Pharmacology

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche

(2019) Abdouramane Camara et al.   IMMUNITY

The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer

(2019) Andrea Doni et al.   Frontiers in Immunology

The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells

(2019) Laura Santambrogio et al.   Frontiers in Immunology

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils

(2019) Akira Takeda et al.   IMMUNITY

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

(2018) David van Dijk et al.   CELL

Lymph node macrophages: Scavengers, immune sentinels and trophic effectors

(2018) Alicia Bellomo et al.   CELLULAR IMMUNOLOGY

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

Leukocyte integrin Mac-1 (CD11b/CD18, αMβ2, CR3) acts as a functional receptor for platelet factor 4

(2018) Valeryi K. Lishko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis

(2018) Roberta Lugano et al.   JOURNAL OF CLINICAL INVESTIGATION

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

(2018) Laleh Haghverdi et al.   NATURE BIOTECHNOLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer

(2018) Cecilia Garlanda et al.   PHYSIOLOGICAL REVIEWS

Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminatingStaphylococcus aureus

(2018) Ania Bogoslowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity

(2018) Laura L. Swystun et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 1 IFN and PD-L1 Coordinate Lymphatic Endothelial Cell Expansion and Contraction during an Inflammatory Immune Response

(2018) Erin D. Lucas et al.   JOURNAL OF IMMUNOLOGY

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

(2018) Imogen Moran et al.   Nature Communications

Multiple roles of lymphatic vessels in peripheral lymph node development

(2018) Esther Bovay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

Interleukin 32, inflammation and cancer

(2017) Jin Tae Hong et al.   PHARMACOLOGY & THERAPEUTICS

Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction

(2017) Ross M. Kedl et al.   Nature Communications

Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

(2017) Julia L. Gregory et al.   Cell Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo

(2016) Junliang Pan et al.   BLOOD

Heterogeneity in the lymphatic vascular system and its origin

(2016) Maria H. Ulvmar et al.   CARDIOVASCULAR RESEARCH

Coordinated lymphangiogenesis is critical in lymph node development and maturation

(2016) Yulia Ga-eun Lee et al.   DEVELOPMENTAL DYNAMICS

The biological function and significance of CD74 in immune diseases

(2016) Huiting Su et al.   INFLAMMATION RESEARCH

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL

(2016) Olga G. Cordeiro et al.   PLoS One

Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

(2016) Bethany A. Kerr et al.   Nature Communications

Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node

(2016) Yang Zhang et al.   eLife

How Mouse Macrophages Sense What Is Going On

(2016) Klaus Ley et al.   Frontiers in Immunology

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers

(2015) Søren Fisker Schmidt et al.   GENOME RESEARCH

The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes

(2015) Pia Rantakari et al.   NATURE IMMUNOLOGY

Stromal infrastructure of the lymph node and coordination of immunity

(2015) Jonathan E. Chang et al.   TRENDS IN IMMUNOLOGY

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

(2015) Sherin J. Rouhani et al.   Nature Communications

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

The Transcription Factor Titration Effect Dictates Level of Gene Expression

(2014) Robert C. Brewster et al.   CELL

Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions

(2014) W. Zheng et al.   GENES & DEVELOPMENT

Steady-State Antigen Scavenging, Cross-Presentation, and CD8+ T Cell Priming: A New Role for Lymphatic Endothelial Cells

(2014) S. Hirosue et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

(2014) Sophie E. Acton et al.   NATURE

The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

(2014) Jillian L Astarita et al.   NATURE IMMUNOLOGY

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes

(2014) Maria H Ulvmar et al.   NATURE IMMUNOLOGY

Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing

(2014) Mike Lee et al.   NATURE IMMUNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment

(2014) Jarish N. Cohen et al.   PLoS One

Mapping the Distinctive Populations of Lymphatic Endothelial Cells in Different Zones of Human Lymph Nodes

(2014) Saem Mul Park et al.   PLoS One

Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection

(2014) Beth A. Tamburini et al.   Nature Communications

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

CD44 Binds to Macrophage Mannose Receptor on Lymphatic Endothelium and Supports Lymphocyte Migration via Afferent Lymphatics

(2013) Marko Salmi et al.   CIRCULATION RESEARCH

Regulation of NF-κB by ubiquitination

(2013) Jueqi Chen et al.   CURRENT OPINION IN IMMUNOLOGY

Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses

(2013) Suvendu Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

Flow control in our vessels: vascular valves make sure there is no way back

(2012) Eleni Bazigou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Smooth muscle–endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation

(2012) Sophie Lutter et al.   JOURNAL OF CELL BIOLOGY

Lymph Node Macrophages

(2012) Elizabeth E. Gray et al.   Journal of Innate Immunity

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines

(2012) Igor Novitzky-Basso et al.   Frontiers in Immunology

Angiopoietin-2 promotes inflammatory lymphangiogenesis and its effect can be blocked by the specific inhibitor L1-10

(2011) Zhi-Xin Yan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Atypical chemokine receptors

(2011) Maria Helena Ulvmar et al.   EXPERIMENTAL CELL RESEARCH

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

(2011) Raghu P. Kataru et al.   IMMUNITY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Reproducible Isolation of Lymph Node Stromal Cells Reveals Site-Dependent Differences in Fibroblastic Reticular Cells

(2011) Anne L. Fletcher et al.   Frontiers in Immunology

Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse

(2010) I. Choi et al.   BLOOD

Development and Migration of Plasma Cells in the Mouse Lymph Node

(2010) David R. Fooksman et al.   IMMUNITY

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BioMart – biological queries made easy

(2009) Damian Smedley et al.   BMC GENOMICS

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

KEGG for representation and analysis of molecular networks involving diseases and drugs

(2009) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

TGFβ-induced protein mediates lymphatic endothelial cell adhesion to the extracellular matrix under low oxygen conditions

(2008) M. Irigoyen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells

(2008) Irina L Grigorova et al.   NATURE IMMUNOLOGY

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

(2008) Monika Pruenster et al.   NATURE IMMUNOLOGY