Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design

(2020) Shan-Meng Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

(2020) Markus Hoffmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Three cases of treatment with Nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy

(2020) Sukbin Jang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

(2020) Sisi Kang et al.   Acta Pharmaceutica Sinica B

Endothelial Injury and Thrombotic Microangiopathy in COVID-19: Treatment with the Lectin-Pathway Inhibitor Narsoplimab

(2020) Alessandro Rambaldi et al.   IMMUNOBIOLOGY

Comparative analysis of antiviral efficacy of FDA‐approved drugs against SARS‐CoV‐2 in human lung cells

(2020) Meehyun Ko et al.   JOURNAL OF MEDICAL VIROLOGY

The Folate Concentration and/or Folic Acid Metabolites in Plasma as Factor for COVID-19 Infection

(2020) Jesus Acosta-Elias et al.   Frontiers in Pharmacology

Identification of a repurposed drug as an inhibitor of Spike protein of human coronavirus SARS-CoV-2 by computational methods

(2020) Sruthi Unni et al.   JOURNAL OF BIOSCIENCES

Preemptive interleukin-6 blockade in patients with COVID-19

(2020) Lucía Guillén et al.   Scientific Reports

Targeting complement cascade: an alternative strategy for COVID-19

(2020) Sureshbabu Ram Kumar Pandian et al.   3 Biotech

Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation

(2020) Pei-Gang Wang et al.   Cell Discovery

Dexamethasone in hospitalised patients with COVID-19: addressing uncertainties

(2020) Michael A Matthay et al.   Lancet Respiratory Medicine

Lung Toxicity in Non–Small-Cell Lung Cancer Patients Exposed to ALK Inhibitors: Report of a Peculiar Case and Systematic Review of the Literature

(2018) Benedetta Pellegrino et al.   Clinical Lung Cancer

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

The role of C5a in acute lung injury induced by highly pathogenic viral infections

(2015) Renxi Wang et al.   Emerging Microbes & Infections

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Toward a structure-based comprehension of the lectin pathway of complement

(2013) Troels R. Kjaer et al.   MOLECULAR IMMUNOLOGY

Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2

(2012) Dávid Héja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for activation of the complement system by component C4 cleavage

(2012) R. T. Kidmose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Complement and viral pathogenesis

(2011) Kristina A. Stoermer et al.   VIROLOGY

Protease inhibitor nafamostat mesilate attenuates complement activation and improves function of xenografts in a discordant lung perfusion model

(2011) Tsutomu Tagawa   XENOTRANSPLANTATION

Empirical Scoring Functions for Advanced Protein−Ligand Docking with PLANTS

(2009) Oliver Korb et al.   Journal of Chemical Information and Modeling