Structural diversity of p63 and p73 isoforms

Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

(2022) Ananya Chakravarti et al.   eLife

The p63 C-terminus is essential for murine oocyte integrity

(2021) Anna Maria Lena et al.   Nature Communications

Isoform-Specific Roles of Mutant p63 in Human Diseases

(2021) Christian Osterburg et al.   Cancers

Mechanisms of quality control differ in male and female germ cells

(2021) Eleonora Candi et al.   CELL DEATH AND DIFFERENTIATION

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Tissue-specific expression of p73 and p63 isoforms in human tissues

(2021) Clayton B. Marshall et al.   Cell Death & Disease

Familial cleft tongue caused by a unique translation initiation codon variant in TP63

(2021) Julia Schmidt et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health

(2020) Jessica M. Stringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P73 C-terminus is dispensable for multiciliogenesis

(2020) Niall Buckley et al.   CELL CYCLE

The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules

(2020) Jan Keiten-Schmitz et al.   MOLECULAR CELL

p63 uses a switch-like mechanism to set the threshold for induction of apoptosis

(2020) Jakob Gebel et al.   Nature Chemical Biology

The C terminus of p73 is essential for hippocampal development

(2020) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damaged Induced Cell Death in Oocytes

(2020) Jakob Gebel et al.   MOLECULES

Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

(2020) Konstantin Riege et al.   eLife

The C-terminal SAM domain of p73 binds to the N terminus of MDM2

(2019) José L. Neira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

p73 regulates epidermal wound healing and induced keratinocyte programming

(2019) J. Scott Beeler et al.   PLoS One

p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytes

(2019) Jieqiong Qu et al.   Epigenetics & Chromatin

Ovarian Follicle Depletion Induced by Chemotherapy and the Investigational Stages of Potential Fertility-Protective Treatments—A Review

(2019) Xia Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

(2019) Shuo Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain

(2019) Susanne Pitzius et al.   Cell Death & Disease

Ovarian damage from chemotherapy and current approaches to its protection

(2019) N Spears et al.   HUMAN REPRODUCTION UPDATE

Characterization of p53 Family Homologs in Evolutionary Remote Branches of Holozoa

(2019) Martin Bartas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Binding Kinetics of the Intrinsically Disordered p53 Family Transactivation Domains and MDM2

(2018) Emma Åberg et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

(2018) Marcel Tuppi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain

(2018) Katharina Krauskopf et al.   STRUCTURE

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

(2018) Marcel Tuppi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sam domains in multiple diseases

(2018) Marian Vincenzi et al.   CURRENT MEDICINAL CHEMISTRY

Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape

(2018) Jieqiong Qu et al.   Cell Reports

High-resolution array-CGH analysis on 46,XX patients affected by early onset primary ovarian insufficiency discloses new genes involved in ovarian function

(2018) I Bestetti et al.   HUMAN REPRODUCTION

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

(2017) Kanaga Sabapathy et al.   Nature Reviews Clinical Oncology

Evolutionary re-wiring of p63 and the epigenomic regulatory landscape in keratinocytes and its potential implications on species-specific gene expression and phenotypes

(2017) Isha Sethi et al.   NUCLEIC ACIDS RESEARCH

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

(2016) Andreas C. Joerger et al.   Annual Review of Biochemistry

Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

(2016) Jakob Gebel et al.   CELL DEATH AND DIFFERENTIATION

Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family

(2016) Sebastian Kehrloesser et al.   CELL DEATH AND DIFFERENTIATION

TAp73 is a central transcriptional regulator of airway multiciliogenesis

(2016) Alice Nemajerova et al.   GENES & DEVELOPMENT

Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein

(2016) Alexander S. Krois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network

(2016) Clayton B. Marshall et al.   Cell Reports

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

(2016) Daniel Coutandin et al.   eLife

Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

(2016) Yannick von Grabowiecki et al.   eLife

TAp73 promotes anti-senescence-anabolism not proliferation

(2016) Massimiliano Agostini et al.   Aging-US

Solution structure and binding specificity of the p63 DNA binding domain

(2016) Andreas Enthart et al.   Scientific Reports

Characterization of the p300 Taz2–p53 TAD2 Complex and Comparison with the p300 Taz2–p53 TAD1 Complex

(2015) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

Gene regulatory mechanisms orchestrated by p63 in epithelial development and related disorders

(2015) Evelyn N. Kouwenhoven et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition

(2015) Jae-Sun Shin et al.   CELL CYCLE

The function of Drosophila p53 isoforms in apoptosis

(2015) B Zhang et al.   CELL DEATH AND DIFFERENTIATION

Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation

(2015) E. N. Kouwenhoven et al.   EMBO REPORTS

The generation of phosphoserine stretches in phosphoproteins: mechanism and significance

(2015) Luca Cesaro et al.   Molecular BioSystems

p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis

(2015) M. Tashakori et al.   MOLECULAR CANCER RESEARCH

Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma

(2015) M F Riley et al.   ONCOGENE

p63 supports aerobic respiration through hexokinase II

(2015) Guiditta Viticchiè et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural investigations of the p53/p73 homologs from the tunicate speciesCiona intestinalisreveal the sequence requirements for the formation of a tetramerization domain

(2015) Jan Heering et al.   PROTEIN SCIENCE

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense

(2015) Angelo D’Alessandro et al.   Oncotarget

Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes

(2014) Isha Sethi et al.   BMC GENOMICS

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Sorting out the trash: the spatial nature of eukaryotic protein quality control

(2014) Emily M Sontag et al.   CURRENT OPINION IN CELL BIOLOGY

TAp73 is essential for germ cell adhesion and maturation in testis

(2014) Lena Holembowski et al.   JOURNAL OF CELL BIOLOGY

Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

(2014) Birgit Schittek et al.   Molecular Cancer

PML, SUMO, and RNF4: Guardians of Nuclear Protein Quality

(2014) Anne Gärtner et al.   MOLECULAR CELL

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

Functional interplay between MDM2, p63/p73 and mutant p53

(2014) M H Stindt et al.   ONCOGENE

TAp73 is required for spermatogenesis and the maintenance of male fertility

(2014) Satoshi Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53  is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

(2014) S. Senturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

Tracing the Evolution of the p53 Tetramerization Domain

(2014) Andreas C. Joerger et al.   STRUCTURE

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis

(2014) Uwe Knippschild et al.   Frontiers in Oncology

How to best preserve oocytes in female cancer patients exposed to DNA damage inducing therapeutics

(2013) K Hutt et al.   CELL DEATH AND DIFFERENTIATION

Analysis of the oligomeric state and transactivation potential of TAp73α

(2013) L M Luh et al.   CELL DEATH AND DIFFERENTIATION

p73 regulates serine biosynthesis in cancer

(2013) I Amelio et al.   ONCOGENE

Structure and Stability Insights into Tumour Suppressor p53 Evolutionary Related Proteins

(2013) Bruno Pagano et al.   PLoS One

TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor

(2013) M. V. Niklison-Chirou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-specific expression of p73 C-terminal isoforms in mice

(2012) Francesca Grespi et al.   CELL CYCLE

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

(2012) M-L Dichtel-Danjoy et al.   CELL DEATH AND DIFFERENTIATION

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Crystal Structures of the DNA-binding Domain Tetramer of the p53 Tumor Suppressor Family Member p73 Bound to Different Full-site Response Elements

(2012) Abdul S. Ethayathulla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pliable DNA Conformation of Response Elements Bound to Transcription Factor p63

(2012) Chen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73

(2012) Peter Canning et al.   JOURNAL OF MOLECULAR BIOLOGY

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

(2012) Simon S. McDade et al.   NUCLEIC ACIDS RESEARCH

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

(2012) A. S. Ethayathulla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

(2012) John P. Rowell et al.   STRUCTURE

The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles

(2011) Stefano Rufini et al.   BIOCHEMICAL PHARMACOLOGY

Physical Association of HDAC1 and HDAC2 with p63 Mediates Transcriptional Repression and Tumor Maintenance in Squamous Cell Carcinoma

(2011) M. R. Ramsey et al.   CANCER RESEARCH

DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

(2011) Gregor B. Deutsch et al.   CELL

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Regulation of skin aging and heart development by TAp63

(2011) M Paris et al.   CELL DEATH AND DIFFERENTIATION

The maternal genes Ci-p53/p73-a and Ci-p53/p73-b regulate zygotic ZicL expression and notochord differentiation in Ciona intestinalis embryos

(2011) Takeshi Noda   DEVELOPMENTAL BIOLOGY

Structural basis of p63α SAM domain mutants involved in AEC syndrome

(2011) Aruna Sathyamurthy et al.   FEBS Journal

Structure and Kinetic Stability of the p63 Tetramerization Domain

(2011) Eviatar Natan et al.   JOURNAL OF MOLECULAR BIOLOGY

Long-Range Modulation of Chain Motions within the Intrinsically Disordered Transactivation Domain of Tumor Suppressor p53

(2011) Jenifer K. Lum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element

(2011) S. Emamzadah et al.   MOLECULAR CANCER RESEARCH

Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements

(2011) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation

(2011) O. Laptenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes

(2011) Ulrike Beyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A human sterile alpha motif domain polymerizome

(2011) Mary Jane Knight et al.   PROTEIN SCIENCE

TAp63 Is Important for Cardiac Differentiation of Embryonic Stem Cells and Heart Development

(2011) Matthieu Rouleau et al.   STEM CELLS

Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein

(2010) Chul Won Lee et al.   BIOCHEMISTRY

Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73

(2010) Michal Zdzalik et al.   CELL CYCLE

Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells

(2010) Matthew LeBoeuf et al.   DEVELOPMENTAL CELL

Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress

(2010) Ning Wang et al.   EMBO REPORTS

Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript

(2010) Virginie Marcel et al.   FEBS LETTERS

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

(2010) Malka Kitayner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-Wide Mapping Indicates That p73 and p63 Co-Occupy Target Sites and Have Similar DNA-Binding Profiles In Vivo

(2010) Annie Yang et al.   PLoS One

Tracing the protectors path from the germ line to the genome

(2010) D. Coutandin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

(2010) C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAM as a protein interaction domain involved in developmental regulation

(2010) Jörg Schultz et al.   PROTEIN SCIENCE

Apoptosis in the germ line

(2010) R John Aitken et al.   REPRODUCTION

Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer

(2010) Yongheng Chen et al.   STRUCTURE

The Tumor Suppressor p53: From Structures to Drug Discovery

(2010) A. C. Joerger et al.   Cold Spring Harbor Perspectives in Biology

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation

(2010) C E Barton et al.   Cell Death & Disease

The C-terminus of p63 contains multiple regulatory elements with different functions

(2010) W E Straub et al.   Cell Death & Disease

Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

(2010) Evelyn N. Kouwenhoven et al.   PLoS Genetics

Dermatologic findings of ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome

(2009) Meena R. Julapalli et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Spectrum ofp63mutations in a selected patient cohort affected with ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC)

(2009) Tuula Rinne et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Conformational stability and activity of p73 require a second helix in the tetramerization domain

(2009) D Coutandin et al.   CELL DEATH AND DIFFERENTIATION

SKP-ing TAp63: Stem Cell Depletion, Senescence, and Premature Aging

(2009) Veronica G. Beaudry et al.   Cell Stem Cell

TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance

(2009) Xiaohua Su et al.   Cell Stem Cell

Regulation of p53 family members by the ubiquitin-like SUMO system

(2009) Per Stehmeier et al.   DNA REPAIR

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY

Preservation of Fertility in Patients with Cancer

(2009) Jacqueline S. Jeruss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Normal ovarian function and assessment of ovarian reserve in the survivor of childhood cancer

(2009) Robert J. Johnston et al.   PEDIATRIC BLOOD & CANCER

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

(2009) Rose-Anne Romano et al.   PLoS One

Molecular basis of the interactions between the p73 N terminus and p300: Effects on transactivation and modulation by phosphorylation

(2009) S. Burge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

(2009) A. C. Joerger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DeltaNp73 regulates neuronal survival in vivo

(2009) F. Tissir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core

(2009) K. H. Khoo et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation

(2009) Hanqiao Feng et al.   STRUCTURE

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

The p73 DNA Binding Domain Displays Enhanced Stability Relative to Its Homologue, the Tumor Suppressor p53, and Exhibits Cooperative DNA Binding†

(2008) Seema Patel et al.   BIOCHEMISTRY

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

Characterization of genome-wide p53-binding sites upon stress response

(2008) Leonie Smeenk et al.   NUCLEIC ACIDS RESEARCH

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity

(2008) M. Sauer et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a p53 core tetramer bound to DNA

(2008) K A Malecka et al.   ONCOGENE

Reconstitution of Mdm2-Dependent Post-Translational Modifications of p53 in Yeast

(2008) Barbara Di Ventura et al.   PLoS One

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

(2008) M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA