Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How cells ensure correct repair of DNA double-strand breaks

(2018) Joonyoung Her et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

(2018) Quynh-Nhu Nguyen et al.   Cell Death & Disease

Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age

(2018) Amy L. Winship et al.   Scientific Reports

Multidose 5-Fluorouracil is Highly Toxic to Growing Ovarian Follicles in Mice

(2018) Jessica M Stringer et al.   TOXICOLOGICAL SCIENCES

Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide

(2018) Yi Luan et al.   JOURNAL OF ENDOCRINOLOGY

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM

(2017) Yi Zhou et al.   MOLECULAR CELL

The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure

(2017) Vera D. Rinaldi et al.   MOLECULAR CELL

How Is the Number of Primordial Follicles in the Ovarian Reserve Established?1

(2015) John K. Findlay et al.   BIOLOGY OF REPRODUCTION

Functions of the MRE11 complex in the development and maintenance of oocytes

(2015) Akiko Inagaki et al.   CHROMOSOMA

Meiotic Recombination: The Essence of Heredity

(2015) Neil Hunter   Cold Spring Harbor Perspectives in Biology

DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

(2015) Petros Marangos et al.   Nature Communications

DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

(2015) Josie K. Collins et al.   Nature Communications

Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications

(2014) Andy Rimmer et al.   NATURE GENETICS

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

Evaluation of Growth Patterns and Body Composition in C57Bl/6J Mice Using Dual Energy X-Ray Absorptiometry

(2014) Sara Gargiulo et al.   Biomed Research International

Meiotic recombination in mammals: localization and regulation

(2013) Frédéric Baudat et al.   NATURE REVIEWS GENETICS

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

(2013) S. Titus et al.   Science Translational Medicine

The DNA damage response in mammalian oocytes

(2013) John Carroll et al.   Frontiers in Genetics

Genetics of early miscarriage

(2012) Merel M.J. van den Berg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oocytes Progress beyond Prophase in the Presence of DNA Damage

(2012) Petros Marangos et al.   CURRENT BIOLOGY

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

(2012) Jeffrey B Kerr et al.   NATURE MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion

(2012) J B Kerr et al.   REPRODUCTION

RAD51 Plays a Crucial Role in Halting Cell Death Program Induced by Ionizing Radiation in Bovine Oocytes1

(2011) Loro L. Kujjo et al.   BIOLOGY OF REPRODUCTION

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

The p53 family: guardians of maternal reproduction

(2011) Arnold J. Levine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51

(2010) Loro L. Kujjo et al.   PLoS One

Inducible response required for repair of low-dose radiation damage in human fibroblasts

(2010) S. Grudzenski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of offspring from a germline stem cell line derived from neonatal ovaries

(2009) Kang Zou et al.   NATURE CELL BIOLOGY

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY