Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy

Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches

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Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer

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Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

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The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

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Durable and controlled depletion of neutrophils in mice

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Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study

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Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer

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Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

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CD40 Agonist Antibodies in Cancer Immunotherapy

(2019) Robert H. Vonderheide   Annual Review of Medicine

Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors

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The regulatory roles of neutrophils in adaptive immunity

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Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

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Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: A meta-analysis containing 8252 patients

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Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms

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Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy

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ONZIN Upregulation by Mutant p53 Contributes to Osteosarcoma Metastasis Through the CXCL5-MAPK Signaling Pathway

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Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

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Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

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O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors

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Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization

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Infiltrating immune cells and gene mutations in pancreatic ductal adenocarcinoma

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CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

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STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

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Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

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Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2

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Genomic analyses identify molecular subtypes of pancreatic cancer

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Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

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CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer

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Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53

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CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma

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The emerging role of chemokine receptor CXCR2 in cancer progression

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PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways

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CXCR2 inhibition suppresses acute and chronic pancreatic inflammation

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MET is required for the recruitment of anti-tumoural neutrophils

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

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Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

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IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

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Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

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The Transcription Factor GLI1 Modulates the Inflammatory Response during Pancreatic Tissue Remodeling

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CXCL5 Drives Neutrophil Recruitment in TH17-Mediated GN

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Improved vectors and genome-wide libraries for CRISPR screening

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Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

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Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

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Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

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Crosstalk between neutrophils and dendritic cells: a context-dependent process

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CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis

(2012) Monica Roy et al.   Journal of Neuroinflammation

NIH Image to ImageJ: 25 years of image analysis

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Overexpression of CXCL5 Is Associated With Poor Survival in Patients With Pancreatic Cancer

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Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

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Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration

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Tumor-infiltrating neutrophils in pancreatic neoplasia

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A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws

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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

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FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

(2009) Huadong Pei et al.   CANCER CELL

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

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