p53 partial loss-of-function mutations sensitize to chemotherapy

Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy

(2021) Oleg Timofeev et al.   Cancers

Phosphorylation control of p53 DNA binding cooperativity balances tumorigenesis and aging

(2020) Oleg Timofeev et al.   CANCER RESEARCH

p53 directly represses human LINE1 transposons

(2020) Bhavana Tiwari et al.   GENES & DEVELOPMENT

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

(2020) Adam R Blanden et al.   eLife

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

(2019) Lawrence A. Donehower et al.   Cell Reports

Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses

(2019) Oleg Timofeev et al.   EMBO JOURNAL

Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo

(2019) Boris Klimovich et al.   CELL CYCLE

Deciphering p53 signaling in tumor suppression

(2018) Stephano S Mello et al.   CURRENT OPINION IN CELL BIOLOGY

How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance

(2018) Thorsten Stiewe et al.   DRUG RESISTANCE UPDATES

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation

(2018) Eran Kotler et al.   MOLECULAR CELL

Mutational processes shape the landscape of TP53 mutations in human cancer

(2018) Andrew O. Giacomelli et al.   NATURE GENETICS

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

(2017) Kanaga Sabapathy et al.   Nature Reviews Clinical Oncology

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing

(2016) Andrew L. Paek et al.   CELL

Clinical Outcomes ofTP53Mutations in Cancers

(2016) Ana I. Robles et al.   Cold Spring Harbor Perspectives in Medicine

Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia

(2015) M. Andreeff et al.   CLINICAL CANCER RESEARCH

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade

(2014) Bernard Leroy et al.   HUMAN MUTATION

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

(2013) M Kracikova et al.   CELL DEATH AND DIFFERENTIATION

Tumor Suppression by p53: Is Apoptosis Important or Not?

(2013) Hestia Mellert et al.   Cell Reports

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

(2013) Oleg Timofeev et al.   Cell Reports

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

(2013) Katharina Schlereth et al.   PLoS Genetics

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

(2012) James G. Jackson et al.   CANCER CELL

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation

(2011) Yongxing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

(2010) Hussein A. Abbas et al.   Cell Stem Cell

DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

(2010) Katharina Schlereth et al.   MOLECULAR CELL

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

(2010) Malka Kitayner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mouse models of human AML accurately predict chemotherapy response

(2009) J. Zuber et al.   GENES & DEVELOPMENT

p53-dependent senescence delays Eμ-myc-induced B-cell lymphomagenesis

(2009) S M Post et al.   ONCOGENE

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry