Mucus sialylation determines intestinal host-commensal homeostasis

Acetate Induces Growth Arrest in Colon Cancer Cells Through Modulation of Mitochondrial Function

(2021) Meliz Sahuri-Arisoylu et al.   Frontiers in Nutrition

Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion

(2021) Zuojia Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Display of the human mucinome with defined O-glycans by gene engineered cells

(2021) Rebecca Nason et al.   Nature Communications

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

(2020) Matthew R. Kudelka et al.   Nature Reviews Gastroenterology & Hepatology

Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation

(2020) Amrita Banerjee et al.   GASTROENTEROLOGY

N-glycosylation of the human β1,4-galactosyltransferase 4 is crucial for its activity and Golgi localization

(2020) Auhen Shauchuk et al.   GLYCOCONJUGATE JOURNAL

Global view of human protein glycosylation pathways and functions

(2020) Katrine T. Schjoldager et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

(2020) Kirk Bergstrom et al.   SCIENCE

Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila

(2020) Beatriz Trastoy et al.   Nature Communications

A streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics

(2020) Pan Fang et al.   Nature Communications

Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt

(2020) Amber N. Habowski et al.   Communications Biology

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

(2019) Stacy A. Malaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

(2019) Christopher S. Smillie et al.   CELL

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

(2019) Evan Bolyen et al.   NATURE BIOTECHNOLOGY

A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice

(2019) Marina Liso et al.   INFLAMMATORY BOWEL DISEASES

A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma

(2019) Stefan Salcher et al.   ONCOGENE

Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer

(2019) Michael Kvorjak et al.   Cancer Immunology Research

Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2’s q2-feature-classifier plugin

(2018) Nicholas A. Bokulich et al.   Microbiome

The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice

(2018) Minna Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

(2018) Liliana R. Loureiro et al.   Scientific Reports

Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine

(2018) Hao Chi et al.   NATURE BIOTECHNOLOGY

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

(2017) Joseph M. Pickard et al.   IMMUNOLOGICAL REVIEWS

Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity

(2017) Jillian M. Prendergast et al.   mAbs

Expression system for structural and functional studies of human glycosylation enzymes

(2017) Kelley W Moremen et al.   Nature Chemical Biology

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis

(2017) Derrick D Eichele et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission

(2017) So Hee Ko et al.   Scientific Reports

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

The Role of Sialyl-Tn in Cancer

(2016) Jennifer Munkley   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells

(2016) Arnold Hayer et al.   NATURE CELL BIOLOGY

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2

(2016) Marijn C. Visschedijk et al.   PLoS One

Microbial metabolite butyrate facilitates M2 macrophage polarization and function

(2016) Jian Ji et al.   Scientific Reports

An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography–tandem mass spectrometry

(2015) Jun Han et al.   ANALYTICA CHIMICA ACTA

Acetate Supplementation as a Means of Inducing Glioblastoma Stem-Like Cell Growth Arrest

(2015) Patrick M. Long et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mucosal Barrier Depletion and Loss of Bacterial Diversity are Primary Abnormalities in Paediatric Ulcerative Colitis

(2015) Misagh Alipour et al.   Journal of Crohns & Colitis

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Cotranslational and posttranslocational N-glycosylation of proteins in the endoplasmic reticulum

(2015) Shiteshu Shrimal et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

The role of glycosylation in IBD

(2014) Evropi Theodoratou et al.   Nature Reviews Gastroenterology & Hepatology

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Mutation in ST6GALNAC5 identified in family with coronary artery disease

(2014) Kolsoum InanlooRahatloo et al.   Scientific Reports

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Induced and Natural Regulatory T Cells in the Development of Inflammatory Bowel Disease

(2013) Christopher G. Mayne et al.   INFLAMMATORY BOWEL DISEASES

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Sialic acid metabolism and sialyltransferases: natural functions and applications

(2012) Yanhong Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Structure and Biological Roles of Mucin-type O-glycans at the Ocular Surface

(2012) Ana Guzman-Aranguez et al.   Ocular Surface

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Mucins in inflammatory bowel diseases and colorectal cancer

(2011) Yong H Sheng et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Mechanisms of Protein Retention in the Golgi

(2011) D. K. Banfield   Cold Spring Harbor Perspectives in Biology

Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission

(2010) Henrike M. Hamer et al.   CLINICAL NUTRITION

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis

(2009) Michael Gersemann et al.   DIFFERENTIATION

Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein

(2009) Malin E. V. Johansson et al.   JOURNAL OF PROTEOME RESEARCH

Glycosylation of human fetal mucins: a similar repertoire of O-glycans along the intestinal tract

(2008) Catherine Robbe-Masselot et al.   GLYCOCONJUGATE JOURNAL

Sialic acids in human health and disease

(2008) Ajit Varki   TRENDS IN MOLECULAR MEDICINE