Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity

Antibody-drug conjugates—an emerging class of cancer treatment

(2016) Nikolaos Diamantis et al.   BRITISH JOURNAL OF CANCER

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models

(2016) F. Li et al.   CANCER RESEARCH

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Role of antibodies in diagnosis and treatment of ovarian cancer: Basic approach and clinical status

(2016) Priyanka Bhatt et al.   JOURNAL OF CONTROLLED RELEASE

Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigen

(2016) Christine Sedlik et al.   OncoImmunology

Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine

(2015) Zhaojun Yin et al.   ACS Chemical Biology

Protein Glycosylation in Cancer

(2015) Sean R. Stowell et al.   Annual Review of Pathology-Mechanisms of Disease

Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics

(2015) Eunhee G. Kim et al.   Biomolecules & Therapeutics

Phase 2 study of frontline brentuximab vedotin monotherapy in Hodgkin lymphoma patients aged 60 years and older

(2015) Andres Forero-Torres et al.   BLOOD

A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti-tumor activity

(2015) Xuejing Yao et al.   BREAST CANCER RESEARCH AND TREATMENT

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

(2015) Bianca T. Hofmann et al.   Molecular Cancer

Glycosyltransferases as Markers for Early Tumorigenesis

(2015) Ulrich Andergassen et al.   Biomed Research International

Trial watch: Tumor-targeting monoclonal antibodies for oncological indications

(2015) Erika Vacchelli et al.   OncoImmunology

The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL

(2015) Richard Beatson et al.   PLoS One

Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells

(2014) Mylène A. Carrascal et al.   Molecular Oncology

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

Aiming at the sweet side of cancer: Aberrant glycosylation as possible target for personalized-medicine

(2013) Vered Padler-Karavani   CANCER LETTERS

Antibody–drug conjugates: current status and future directions

(2013) Heidi L. Perez et al.   DRUG DISCOVERY TODAY

Cell surface protein glycosylation in cancer

(2013) Maja N. Christiansen et al.   PROTEOMICS

Tn and sialyl-Tn antigens, aberrantO-glycomics as human disease markers

(2013) Tongzhong Ju et al.   Proteomics Clinical Applications

CpG ODN and ISCOMATRIX Adjuvant: A Synergistic Adjuvant Combination Inducing Strong T-Cell IFN-γResponses

(2013) Michael J. McCluskie et al.   Biomed Research International

Survival Advantage in Patients with Metastatic Breast Cancer Receiving Endocrine Therapy plus Sialyl Tn-KLH Vaccine: Post Hoc Analysis of a Large Randomized Trial

(2013) Nuhad K. Ibrahim et al.   Journal of Cancer

Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model

(2012) Hidenori Ozaki et al.   CLINICAL & EXPERIMENTAL METASTASIS

Different Levels of Sialyl-Tn Antigen Expressed on MUC16 in Patients With Endometriosis and Ovarian Cancer

(2012) Kaoru Akita et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

(2012) Peter D Senter et al.   NATURE BIOTECHNOLOGY

Human Xeno-Autoantibodies against a Non-Human Sialic Acid Serve as Novel Serum Biomarkers and Immunotherapeutics in Cancer

(2011) V. Padler-Karavani et al.   CANCER RESEARCH

Phase III Multicenter Clinical Trial of the Sialyl-TN (STn)-Keyhole Limpet Hemocyanin (KLH) Vaccine for Metastatic Breast Cancer

(2011) D. Miles et al.   ONCOLOGIST

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model

(2009) S Julien et al.   BRITISH JOURNAL OF CANCER

Monoclonal Antibodies in Cancer Therapy: 25 Years of Progress

(2008) Robert K. Oldham et al.   JOURNAL OF CLINICAL ONCOLOGY