Sialic acid metabolism and sialyltransferases: natural functions and applications

Polysialic Acid, a Glycan with Highly Restricted Expression, Is Found on Human and Murine Leukocytes and Modulates Immune Responses

(2014) P. M. Drake et al.   JOURNAL OF IMMUNOLOGY

Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of Inhibitors

(2012) Alejandro Buschiazzo et al.   PLoS Pathogens

Biomedical Differences Between Human and Nonhuman Hominids: Potential Roles for Uniquely Human Aspects of Sialic Acid Biology

(2011) Nissi M. Varki et al.   Annual Review of Pathology-Mechanisms of Disease

Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity

(2011) Yanhong Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Identification of a second catalytically active trans-sialidase in Trypanosoma brucei

(2011) Fumiki Nakatani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification, Tissue Distribution, and Molecular Modeling of Novel Human Isoforms of the Key Enzyme in Sialic Acid Synthesis, UDP-GlcNAc 2-Epimerase/ManNAc Kinase

(2011) Tal Yardeni et al.   BIOCHEMISTRY

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: The carbohydrate binding mechanism involves residual sialidase activity

(2011) Pablo Oppezzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chemoenzymatic synthesis of C8-modified sialic acids and related α2–3- and α2–6-linked sialosides

(2011) Hai Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense

(2011) Hendrik Koliwer-Brandl et al.   BMC BIOCHEMISTRY

Human Xeno-Autoantibodies against a Non-Human Sialic Acid Serve as Novel Serum Biomarkers and Immunotherapeutics in Cancer

(2011) V. Padler-Karavani et al.   CANCER RESEARCH

Trans-sialidase and mucins of Trypanosoma cruzi: an important interplay for the parasite

(2011) M. Eugenia Giorgi et al.   CARBOHYDRATE RESEARCH

PmST2: A novel Pasteurella multocida glycolipid α2-3-sialyltransferase

(2011) Vireak Thon et al.   GLYCOBIOLOGY

Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia

(2011) C. Mandal et al.   GLYCOBIOLOGY

Characterization and Acceptor Preference of a Soluble Meningococcal Group C Polysialyltransferase

(2011) D. C. Peterson et al.   JOURNAL OF BACTERIOLOGY

Structure and Mechanism of the Lipooligosaccharide Sialyltransferase fromNeisseria meningitidis

(2011) Leo Y.-C. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Infant-associated Bacterial Commensal Utilizes Breast Milk Sialyloligosaccharides

(2011) David A. Sela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Sialylated Glycan Microarray Reveals Novel Interactions of Modified Sialic Acids with Proteins and Viruses

(2011) Xuezheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Influenza Virus Hemagglutinin Receptor Binding Mutants with Limited Receptor Recognition Properties and Conditional Replication Characteristics

(2011) K. C. Bradley et al.   JOURNAL OF VIROLOGY

Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies

(2011) Yanhong Li et al.   Molecular BioSystems

Fluorescent labeling agents change binding profiles of glycan-binding proteins

(2011) Yiyan Fei et al.   Molecular BioSystems

Decreasing the sialidase activity of multifunctional Pasteurella multocidaα2–3-sialyltransferase 1 (PmST1) by site-directed mutagenesis

(2011) Go Sugiarto et al.   Molecular BioSystems

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives

(2011) Kam Lau et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biosynthesis and production of polysialic acids in bacteria

(2010) Miguel Ángel Ferrero et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Efficient synthesis of 6′-sialyllactose, 6,6′-disialyllactose, and 6′-KDO-lactose by metabolically engineered E. coli expressing a multifunctional sialyltransferase from the Photobacterium sp. JT-ISH-224

(2010) Sophie Drouillard et al.   CARBOHYDRATE RESEARCH

Advances in the Structure-Based Design of the Influenza A Neuraminidase Inhibitors

(2010) Petar Mitrasinovic   CURRENT DRUG TARGETS

Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis

(2010) Louise E. Horsfall et al.   FEBS Journal

Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells

(2010) S. Inoue et al.   GLYCOBIOLOGY

The human Cas1 protein: A sialic acid-specific O-acetyltransferase?

(2010) S. Arming et al.   GLYCOBIOLOGY

Cloning and characterization of a viral α2–3-sialyltransferase (vST3Gal-I) for the synthesis of sialyl Lewisx

(2010) Go Sugiarto et al.   GLYCOBIOLOGY

Continuous nonradioactive method for screening trypanosomal trans-sialidase activity and its inhibitors

(2010) P. A. Sartor et al.   GLYCOBIOLOGY

Current trends in the structure-activity relationships of sialyltransferases

(2010) M. Audry et al.   GLYCOBIOLOGY

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acidN-glycolylneuraminic acid

(2010) Rachel E. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemoenzymatic Synthesis and Enzymatic Analysis of 8-Modified Cytidine Monophosphate-Sialic Acid and Sialyl Lactose Derivatives

(2010) Thomas J. Morley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescence Activated Cell Sorting as a General Ultra-High-Throughput Screening Method for Directed Evolution of Glycosyltransferases

(2010) Guangyu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

(2010) Darius Ghaderi et al.   NATURE BIOTECHNOLOGY

Advances in the Development of Vaccines againstNeisseria meningitidis

(2010) Lionel K.K. Tan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fabrication and Characterization of a Sialoside-Based Carbohydrate Microarray Biointerface for Protein Binding Analysis with Surface Plasmon Resonance Imaging

(2009) Matthew J. Linman et al.   ACS Applied Materials & Interfaces

Advances in the Biology and Chemistry of Sialic Acids

(2009) Xi Chen et al.   ACS Chemical Biology

NMR Spectroscopic Characterization of the Sialyltransferase CstII fromCampylobacter jejuni: Histidine 188 Is the General Base

(2009) Patrick H. W. Chan et al.   BIOCHEMISTRY

Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid

(2009) Hongzhi Cao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

(2009) T. Pham et al.   BLOOD

Insights into the evolution of sialic acid catabolism among bacteria

(2009) Salvador Almagro-Moreno et al.   BMC EVOLUTIONARY BIOLOGY

Comparative Sequence Analysis in the Sialyltransferase Protein Family: Analysis of Motifs

(2009) Arun Datta   CURRENT DRUG TARGETS

Crystal structure ofα/β-galactosideα2,3-sialyltransferase from a luminous marine bacterium,Photobacterium phosphoreum

(2009) Toru Iwatani et al.   FEBS LETTERS

An  2,6-sialyltransferase cloned from Photobacterium leiognathi strain JT-SHIZ-119 shows both sialyltransferase and neuraminidase activity

(2009) T. Mine et al.   GLYCOBIOLOGY

Trans-sialidase activity of Photobacterium damsela  2,6-sialyltransferase and its application in the synthesis of sialosides

(2009) J. Cheng et al.   GLYCOBIOLOGY

Metabolic glycoengineering: Sialic acid and beyond

(2009) Jian Du et al.   GLYCOBIOLOGY

An Orthologue of Bacteroides fragilis NanH Is the Principal Sialidase in Tannerella forsythia

(2009) H. Thompson et al.   JOURNAL OF BACTERIOLOGY

Chemoenzymatic Synthesis of a New Class of Macrocyclic Oligosaccharides

(2009) Saddam Muthana et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemoenzymatic Synthesis of GD3 Oligosaccharides and Other Disialyl Glycans Containing Natural and Non-natural Sialic Acids

(2009) Hai Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural insight into mammalian sialyltransferases

(2009) Francesco V Rao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glycan terminator

(2009) James C Paulson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids

(2009) Hongzhi Cao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Trans-sialidase from Trypanosoma brucei as a potential target for DNA vaccine development against African trypanosomiasis

(2009) Marcelo Sousa Silva et al.   PARASITOLOGY RESEARCH

Combinatorial Chemoenzymatic Synthesis and High-Throughput Screening of Sialosides

(2008) Harshal A. Chokhawala et al.   ACS Chemical Biology

Surface Plasmon Resonance Study of Protein−Carbohydrate Interactions Using Biotinylated Sialosides

(2008) Matthew J. Linman et al.   ANALYTICAL CHEMISTRY

A New Generation of SpecificTrypanosoma cruzi trans-Sialidase Inhibitors

(2008) Sabrina Buchini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pasteurella multocida sialic acid aldolase: a promising biocatalyst

(2008) Yanhong Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bacterial CMP-sialic acid synthetases: production, properties, and applications

(2008) Rahman M. Mizanur et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Kinetic and Mechanistic Analysis ofTrypanosoma cruziTrans-Sialidase Reveals a Classical Ping-Pong Mechanism with Acid/Base Catalysis†

(2008) Iben Damager et al.   BIOCHEMISTRY

Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid

(2008) Sina Hartlieb et al.   CARBOHYDRATE RESEARCH

Chemo-enzymatic synthesis of C-9 acetylated sialosides

(2008) Jana Rauvolfova et al.   CARBOHYDRATE RESEARCH

Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block

(2008) Hongzhi Cao et al.   CARBOHYDRATE RESEARCH

Structural insights into sialic acid enzymology

(2008) Alejandro Buschiazzo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Multifunctionality of Campylobacter jejuni sialyltransferase CstII: Characterization of GD3/GT3 oligosaccharide synthase, GD3 oligosaccharide sialidase, and trans-sialidase activities

(2008) J. Cheng et al.   GLYCOBIOLOGY

Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease

(2008) V. Padler-Karavani et al.   GLYCOBIOLOGY

Assays of sialate-O-acetyltransferases and sialate-O-acetylesterases

(2008) G. Vinayaga Srinivasan et al.   GLYCOCONJUGATE JOURNAL

High level of sialate-O-acetyltransferase activity in lymphoblasts of childhood acute lymphoblastic leukaemia (ALL): enzyme characterization and correlation with disease status

(2008) Chandan Mandal et al.   GLYCOCONJUGATE JOURNAL

Genetic engineering of Escherichia coli for the economical production of sialylated oligosaccharides

(2008) N FIERFORT et al.   JOURNAL OF BIOTECHNOLOGY

Photoactivatable Crosslinking Sugars for Capturing Glycoprotein Interactions

(2008) Yoshihito Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amino acid 310 determines the donor substrate specificity of serogroup W-135 and Y capsule polymerases ofNeisseria meningitidis

(2008) Heike Claus et al.   MOLECULAR MICROBIOLOGY

Aberrant expression of sialidase and cancer progression

(2008) Taeko MIYAGI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry