Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation

Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants

(2021) Jordan T. Russell et al.   Scientific Reports

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

(2021) Salim S. Virani et al.   CIRCULATION

Effects of Proton Pump Inhibitors on the Small Bowel and Stool Microbiomes

(2021) Stacy Weitsman et al.   DIGESTIVE DISEASES AND SCIENCES

Long-read metagenomics retrieves complete single-contig bacterial genomes from canine feces

(2021) Anna Cuscó et al.   BMC GENOMICS

Tryptophan: From Diet to Cardiovascular Diseases

(2021) Nada Joe Melhem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease

(2021) Pooja S. Salvi et al.   Cells

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism

(2021) Arash Haghikia et al.   EUROPEAN HEART JOURNAL

Gut microbiome of a porcine model of metabolic syndrome and HF-pEF

(2020) Aoife N. O’Donovan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Coronary artery disease is associated with an altered gut microbiome composition

(2020) Takumi Toya et al.   PLoS One

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

(2020) Estefania Sanchez-Rodriguez et al.   Nutrients

The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions

(2020) Marius Trøseid et al.   EBioMedicine

Quantifying Technical Confounders in Microbiome Studies

(2020) Theda U P Bartolomaeus et al.   CARDIOVASCULAR RESEARCH

Trimethylamine N-Oxide in Relation to Cardiometabolic Health—Cause or Effect?

(2020) Christopher Papandreou et al.   Nutrients

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

(2020) Chelsea L. Organ et al.   Journal of the American Heart Association

Gut Microbiota‐Dependent Trimethylamine N‐oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS‐TIMI 54 Trial

(2020) Baris Gencer et al.   Journal of the American Heart Association

Gut microbiota and cardiovascular disease: opportunities and challenges

(2020) Negin Kazemian et al.   Microbiome

Fecal microbiota transplantation from high caloric-fed donors alters glucose metabolism in recipient mice, independently of adiposity or exercise status

(2020) Jereon Zoll et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gut Microbiota and Cardiovascular Disease

(2020) Marco Witkowski et al.   CIRCULATION RESEARCH

How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way?

(2020) Victor Gerdes et al.   ATHEROSCLEROSIS

Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation

(2020) Honghong Liu et al.   Journal of Translational Medicine

Gut microbiota‐derived trimethylamine N ‐oxide is associated with poor prognosis in patients with heart failure

(2020) Wensheng Li et al.   MEDICAL JOURNAL OF AUSTRALIA

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

(2020) Kelly S. Swanson et al.   Nature Reviews Gastroenterology & Hepatology

Gut microbiota in human metabolic health and disease

(2020) Yong Fan et al.   NATURE REVIEWS MICROBIOLOGY

Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis

(2019) Naofumi Yoshida et al.   CIRCULATION

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis

(2019) Eelke Brandsma et al.   CIRCULATION RESEARCH

Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease

(2019) Yuan-Yuan Chen et al.   Journal of Translational Medicine

Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophil:lymphocyte ratio, leading to inflamed milieu in acute heart failure

(2019) Vasundhara Kain et al.   FASEB JOURNAL

Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndromes

(2019) Xinmin S Li et al.   EUROPEAN HEART JOURNAL

Alterations in the gut microbiome and metabolism with coronary artery disease severity

(2019) Honghong Liu et al.   Microbiome

Effects of dietary intervention and n-3 PUFA supplementation on markers of gut-related inflammation and their association with cardiovascular events in a high-risk population

(2019) Ayodeji Awoyemi et al.   ATHEROSCLEROSIS

The gut microbiome: a novel cardio-metabolic target?

(2019) Jyoti Patel   CARDIOVASCULAR RESEARCH

The intestinal microbiota and cardiovascular disease

(2019) Themistoklis Katsimichas et al.   CARDIOVASCULAR RESEARCH

Assessment of Causal Direction Between Gut Microbiota-Dependent Metabolites and Cardiometabolic Health: Abi-Directional Mendelian Randomisation Analysis

(2019) Jinzhu Jia et al.   DIABETES

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

(2019) Anthony T. Virtue et al.   Science Translational Medicine

The Mediterranean diet and its association with selected gut bacteria

(2019) Željko Krznarić et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The role of diet and intestinal microbiota in the development of metabolic syndrome

(2019) Jose A. Santos-Marcos et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Factors affecting the composition of the gut microbiota, and its modulation

(2019) Nihal Hasan et al.   PeerJ

Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases

(2019) Soraya Taleb   Frontiers in Immunology

Gut Microbiome and Response to Cardiovascular Drugs

(2019) Sony Tuteja et al.   Circulation-Genomic and Precision Medicine

The Potential of Probiotics in the Prevention and Treatment of Atherosclerosis

(2019) Victoria L. O'Morain et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice

(2019) Klytaimnistra Kiouptsi et al.   mBio

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

(2018) Eleni Beli et al.   DIABETES

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans

(2018) JACOB M. ALLEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

(2018) Ludivine Laurans et al.   NATURE MEDICINE

Best practices for analysing microbiomes

(2018) Rob Knight et al.   NATURE REVIEWS MICROBIOLOGY

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts

(2018) Ramón Estruch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research

(2018) Patrick D. Schloss   mBio

Lactobacillus plantarum ZDY04 exhibits strain-specific property of lowering-TMAO via modulation of gut microbiota in mice

(2018) Liang Qiu et al.   Food & Function

Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population

(2018) Izaskun Garcia-Mantrana et al.   Frontiers in Microbiology

Body Mass Index and Sex Affect Diverse Microbial Niches within the Gut

(2018) Francesca Borgo et al.   Frontiers in Microbiology

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Prebiotics and Probiotics in Digestive Health

(2018) Eamonn M.M. Quigley   Clinical Gastroenterology and Hepatology

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

(2018) Adam B. Roberts et al.   NATURE MEDICINE

Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies

(2018) I. C. L. van den Munckhof et al.   Obesity Reviews

Dysbiosis signatures of gut microbiota in coronary artery disease

(2018) Qi Zhu et al.   PHYSIOLOGICAL GENOMICS

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

(2017) Gabriele Giacomo Schiattarella et al.   EUROPEAN HEART JOURNAL

Mediterranean diet impact on cardiovascular diseases

(2017) Anna V. Mattioli et al.   Journal of Cardiovascular Medicine

Faecal microbiota transplantation for Clostridium difficile-associated diarrhoea: a systematic review of randomised controlled trials

(2017) Paul Moayyedi et al.   MEDICAL JOURNAL OF AUSTRALIA

Shotgun metagenomics, from sampling to analysis

(2017) Christopher Quince et al.   NATURE BIOTECHNOLOGY

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

Association Study of Gut Flora in Coronary Heart Disease through High-Throughput Sequencing

(2017) Li Cui et al.   Biomed Research International

Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies

(2017) Yoriko Heianza et al.   Journal of the American Heart Association

Gut‐Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet

(2017) Daniele Pastori et al.   Journal of the American Heart Association

The changes of gut microbiota after acute myocardial infarction in rats

(2017) Ze-Xuan Wu et al.   PLoS One

The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis

(2016) Karolina Skagen et al.   ATHEROSCLEROSIS

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials

(2016) Elham Nikbakht et al.   EUROPEAN JOURNAL OF NUTRITION

A Randomized Controlled Clinical Trial Investigating the Effect of Synbiotic Administration on Markers of Insulin Metabolism and Lipid Profiles in Overweight Type 2 Diabetic Patients with Coronary Heart Disease

(2016) M. Tajabadi-Ebrahimi et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Antibiotics as deep modulators of gut microbiota: between good and evil

(2016) Gianluca Ianiro et al.   GUT

Microbiota-induced obesity requires farnesoid X receptor

(2016) Ava Parséus et al.   GUT

Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease

(2016) Takuo Emoto et al.   Journal of Atherosclerosis and Thrombosis

Plasma Trimethylamine N -Oxide, a Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden

(2016) Vichai Senthong et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Probiotics, gut microbiota, and their influence on host health and disease

(2016) Borja Sánchez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Role of gut microbiota in atherosclerosis

(2016) Annika Lindskog Jonsson et al.   Nature Reviews Cardiology

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Microbiota‐Dependent Metabolite Trimethylamine N‐Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)

(2016) Katie A. Meyer et al.   Journal of the American Heart Association

Trimethylamine N ‐Oxide and Mortality Risk in Patients With Peripheral Artery Disease

(2016) Vichai Senthong et al.   Journal of the American Heart Association

The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases

(2015) J. Mark Brown et al.   Annual Review of Medicine

Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control

(2015) Daniel M. Mueller et al.   ATHEROSCLEROSIS

The truth about metagenomics: quantifying and counteracting bias in 16S rRNA studies

(2015) J Paul Brooks et al.   BMC MICROBIOLOGY

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood LipidsNovelty and Significance

(2015) Jingyuan Fu et al.   CIRCULATION RESEARCH

Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of Diabetes

(2015) Franklin F. Duan et al.   DIABETES

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Proton pump inhibitors affect the gut microbiome

(2015) Floris Imhann et al.   GUT

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

How the Seven Countries Study contributed to the definition and development of the Mediterranean diet concept: A 50-year journey

(2015) A. Menotti et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Fat, fibre and cancer risk in African Americans and rural Africans

(2015) Stephen J. D. O’Keefe et al.   Nature Communications

Sparse and Compositionally Robust Inference of Microbial Ecological Networks

(2015) Zachary D. Kurtz et al.   PLoS Computational Biology

Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack

(2015) Jia Yin et al.   Journal of the American Heart Association

Probiotic Administration Attenuates Myocardial Hypertrophy and Heart Failure After Myocardial Infarction in the Rat

(2014) Xiaohong Tracey Gan et al.   Circulation-Heart Failure

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

(2014) Jill C. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Consumption of Synbiotic Bread Decreases Triacylglycerol and VLDL Levels While Increasing HDL Levels in Serum from Patients with Type-2 Diabetes

(2014) Hossein Shakeri et al.   LIPIDS

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

Choice of bacterial DNA extraction method from fecal material influences community structure as evaluated by metagenomic analysis

(2014) Agata Wesolowska-Andersen et al.   Microbiome

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

(2012) Yan Y. Lam et al.   PLoS One

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

(2011) Rima Kaddurah-Daouk et al.   PLoS One

Lactobacillus acidophilus CHO-220 and inulin reduced plasma total cholesterol and low-density lipoprotein cholesterol via alteration of lipid transporters

(2010) L.-G. Ooi et al.   JOURNAL OF DAIRY SCIENCE

Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation

(2010) Fabienne Laugerette et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota

(2009) Shigemitsu Tanaka et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The gut microbiota modulates host energy and lipid metabolism in mice

(2009) Vidya R. Velagapudi et al.   JOURNAL OF LIPID RESEARCH

What are the consequences of the disappearing human microbiota?

(2009) Martin J. Blaser et al.   NATURE REVIEWS MICROBIOLOGY

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine