Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Nutrition, Obesity and Cachexia in Patients with Heart Failure: A Consensus Statement from the HFSA Scientific Statements Committee

(2019) Amanda R. Vest et al.   JOURNAL OF CARDIAC FAILURE

Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3 ) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels—Brief Report

(2019) Diana M. Shih et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure

(2018) Jessica M. Bradley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Novel Fibroblast Activation Inhibitor Attenuates Left Ventricular Remodeling and Preserves Cardiac Function in Heart Failure

(2018) Jessica M Bradley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk

(2018) W. Zhu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide

(2018) Monia Savi et al.   MOLECULES

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

(2018) Adam B. Roberts et al.   NATURE MEDICINE

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential

(2018) Sarah M. Skye et al.   CIRCULATION RESEARCH

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women

(2018) Zeneng Wang et al.   EUROPEAN HEART JOURNAL

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

(2017) Gabriele Giacomo Schiattarella et al.   EUROPEAN HEART JOURNAL

Circulating trimethylamine N-oxide and the risk of cardiovascular diseases: a systematic review and meta-analysis of 11 prospective cohort studies

(2017) Jiaqian Qi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney

(2017) David J. Polhemus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Contributory Risk and Management of Comorbidities of Hypertension, Obesity, Diabetes Mellitus, Hyperlipidemia, and Metabolic Syndrome in Chronic Heart Failure: A Scientific Statement From the American Heart Association

(2016) Biykem Bozkurt et al.   CIRCULATION

Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide SignalingNovelty and Significance

(2016) David J. Polhemus et al.   CIRCULATION RESEARCH

TrimethylamineN-oxide and prognosis in acute heart failure

(2016) Toru Suzuki et al.   HEART

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

(2016) Catharina Missailidis et al.   PLoS One

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure

(2015) W.H. Wilson Tang et al.   JOURNAL OF CARDIAC FAILURE

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Characterization of Choline Trimethylamine-Lyase Expands the Chemistry of Glycyl Radical Enzymes

(2014) Smaranda Craciun et al.   ACS Chemical Biology

Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry

(2014) Zeneng Wang et al.   ANALYTICAL BIOCHEMISTRY

γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO

(2014) Robert A. Koeth et al.   Cell Metabolism

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

(2014) Jill C. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

(2014) Diana M. Shih et al.   JOURNAL OF LIPID RESEARCH

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

H 2 S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase

(2013) Kazuhisa Kondo et al.   CIRCULATION

Hydrogen Sulfide Attenuates Cardiac Dysfunction After Heart Failure Via Induction of Angiogenesis

(2013) David J. Polhemus et al.   Circulation-Heart Failure

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism

(2010) R. Caesar et al.   JOURNAL OF INTERNAL MEDICINE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Choline: an essential nutrient for public health

(2009) Steven H Zeisel et al.   NUTRITION REVIEWS

Structural Analysis of Sensor Domains from the TMAO-Responsive Histidine Kinase Receptor TorS

(2009) Jason O. Moore et al.   STRUCTURE