Metabotropic glutamate receptor 5 upregulation of γ-aminobutyric acid transporter 3 expression ameliorates cognitive impairment after traumatic brain injury in mice

Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons

(2021) Felicia Mermer et al.   BRAIN

Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD

(2021) Sarah Poliquin et al.   EXPERIMENTAL NEUROLOGY

Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

(2020) Shahnawaz A. Bhat et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacological activation of mGlu5 receptors with the positive allosteric modulator, VU0360172 modulates thalamic GABAergic transmission

(2020) Roberta Celli et al.   NEUROPHARMACOLOGY

The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons

(2020) Andrés González-Gutiérrez et al.   JOURNAL OF NEUROSCIENCE

Cognitive Impairment Following Acute Mild Traumatic Brain Injury

(2019) Maíra Glória de Freitas Cardoso et al.   Frontiers in Neurology

A Hit, a Hit—A Very Palpable Hit: Mild TBI and the Development of Epilepsy

(2019) Steve C. Danzer   Epilepsy Currents

Questions and (some) answers on reactive astrocytes

(2019) Carole Escartin et al.   GLIA

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

(2019) Si Yun Ng et al.   Frontiers in Cellular Neuroscience

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior

(2018) Xinzhu Yu et al.   NEURON

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

(2017) Jordano Brito-Moreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice

(2017) Maria EK Lie et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Direct current stimulation induces mGluR5-dependent neocortical plasticity

(2016) Yan Sun et al.   ANNALS OF NEUROLOGY

Orchestrated activation of mGluR5 and CB1 promotes neuroprotection

(2016) Edleusa M. L. Batista et al.   Molecular Brain

Reduced tonic inhibition after stroke promotes motor performance and epileptic seizures

(2016) Nadine Jaenisch et al.   Scientific Reports

Glutamate and GABA Imbalance Following Traumatic Brain Injury

(2015) Réjean M. Guerriero et al.   Current Neurology and Neuroscience Reports

Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents

(2015) Jerri M. Rook et al.   NEURON

The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates

(2015) Isabella M Guimaraes et al.   Molecular Brain

Functional regeneration beyond the glial scar

(2014) Jared M. Cregg et al.   EXPERIMENTAL NEUROLOGY

Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats

(2014) V. D'Amore et al.   NEUROPHARMACOLOGY

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

(2014) David J. Loane et al.   Neurotherapeutics

Structure, function, and plasticity of GABA transporters

(2014) Annalisa Scimemi   Frontiers in Cellular Neuroscience

Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model

(2014) Zheng Wu et al.   Nature Communications

Development of allosteric modulators of GPCRs for treatment of CNS disorders

(2013) Hilary Highfield Nickols et al.   NEUROBIOLOGY OF DISEASE

Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats

(2012) Jia-Wei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury

(2012) Jia-Wei Wang et al.   BRAIN RESEARCH

Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

(2012) David J. Loane et al.   JOURNAL OF NEUROTRAUMA

Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats

(2012) V. D'Amore et al.   NEUROPHARMACOLOGY

Altered Bidirectional Plasticity and Reduced Implicit Motor Learning in Concussed Athletes

(2011) L. De Beaumont et al.   CEREBRAL CORTEX

Mecanismos biológicos involucrados en la propagación del daño en el traumatismo encéfalo craneano

(2011) M. Rovegno et al.   Medicina Intensiva

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

(2010) Teuntje M. J. C. Andriessen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Cognitive Outcome Following Traumatic Brain Injury

(2009) Sureyya S. Dikmen et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Mouse closed head injury model induced by a weight-drop device

(2009) Michael A Flierl et al.   Nature Protocols

Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus

(2009) Jason M. Uslaner et al.   NEUROPHARMACOLOGY

mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning

(2009) Jennifer E Ayala et al.   NEUROPSYCHOPHARMACOLOGY

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

(2008) Kimberly R. Byrnes et al.   Neurotherapeutics