GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

(2016) Vicente Hernandez-Rabaza et al.   Journal of Neuroinflammation

Effects of the Selective α5-GABAAR Antagonist S44819 on Excitability in the Human Brain: A TMS–EMG and TMS–EEG Phase I Study

(2016) Ghazaleh Darmani et al.   JOURNAL OF NEUROSCIENCE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Reduced tonic inhibition after stroke promotes motor performance and epileptic seizures

(2016) Nadine Jaenisch et al.   Scientific Reports

Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice

(2016) Claudia Alia et al.   Scientific Reports

Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective

(2015) Silke Neumann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function

(2015) Evelyn MR Lake et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Optogenetic Mapping after Stroke Reveals Network-Wide Scaling of Functional Connections and Heterogeneous Recovery of the Peri-Infarct

(2014) Diana H. Lim et al.   JOURNAL OF NEUROSCIENCE

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

(2014) Jonathan Emberson et al.   LANCET

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1)

(2014) Anas Al-Khawaja et al.   NEUROCHEMICAL RESEARCH

Memantine Enhances Recovery From Stroke

(2014) Héctor E. López-Valdés et al.   STROKE

Multimodal Examination of Structural and Functional Remapping in the Mouse Photothrombotic Stroke Model

(2013) Andrew N Clarkson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus

(2013) Flavie Kersanté et al.   JOURNAL OF PHYSIOLOGY-LONDON

Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources

(2013) Inseon Song et al.   Frontiers in Cellular Neuroscience

Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

(2012) Stephen G. Brickley et al.   NEURON

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

(2010) Andrew N. Clarkson et al.   NATURE

The Four Human γ-Aminobutyric Acid (GABA) Transporters: Pharmacological Characterization and Validation of a Highly Efficient Screening Assay

(2009) Trine Kvist et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

In Vivo Voltage-Sensitive Dye Imaging in Adult Mice Reveals That Somatosensory Maps Lost to Stroke Are Replaced over Weeks by New Structural and Functional Circuits with Prolonged Modes of Activation within Both the Peri-Infarct Zone and Distant Sites

(2009) C. E. Brown et al.   JOURNAL OF NEUROSCIENCE

Plasticity during stroke recovery: from synapse to behaviour

(2009) Timothy H. Murphy et al.   NATURE REVIEWS NEUROSCIENCE

Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery

(2008) Steven C. Cramer   ANNALS OF NEUROLOGY

A new penumbra: transitioning from injury into repair after stroke

(2008) Eng H Lo   NATURE MEDICINE

Neuroprotection for ischemic stroke: Past, present and future

(2008) Myron D. Ginsberg   NEUROPHARMACOLOGY