Orchestrated activation of mGluR5 and CB1 promotes neuroprotection

The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway

(2015) C Blázquez et al.   CELL DEATH AND DIFFERENTIATION

Alzheimer’s Disease: Lessons Learned from Amyloidocentric Clinical Trials

(2015) Andreas Soejitno et al.   CNS DRUGS

Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis

(2015) Miao Liu et al.   Journal of Neuroinflammation

Homer Protein-Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling and Affects Hyperexcitability in a Mouse Model of Fragile X Syndrome

(2015) A.-H. Tang et al.   JOURNAL OF NEUROSCIENCE

The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease

(2015) J.G. Doria et al.   NEUROBIOLOGY OF DISEASE

Activation of mGluR5 Attenuates Microglial Activation and Neuronal Apoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats

(2015) Zong-yong Zhang et al.   NEUROCHEMICAL RESEARCH

Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity

(2015) Luciano R. Vilela et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates

(2015) Isabella M Guimaraes et al.   Molecular Brain

Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice

(2014) Alipi V. Naydenov et al.   NEUROBIOLOGY OF DISEASE

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

(2014) David J. Loane et al.   Neurotherapeutics

Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease

(2013) JG Doria et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition

(2013) Christoph Stumm et al.   NEUROBIOLOGY OF AGING

Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats

(2013) Kieran Rea et al.   PAIN

mGluR5 Ablation in Cortical Glutamatergic Neurons Increases Novelty-Induced Locomotion

(2013) Chris P. Jew et al.   PLoS One

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

(2012) Ana María Martín-Moreno et al.   Journal of Neuroinflammation

Protective Effects of mGluR5 Positive Modulators Against Traumatic Neuronal Injury Through PKC-Dependent Activation of MEK/ERK Pathway

(2012) Tao Chen et al.   NEUROCHEMICAL RESEARCH

Interactions of CB1 and mGlu5 receptor antagonists in food intake, anxiety and memory models in rats

(2012) Balázs Varga et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

(2012) Kwang-Mook Jung et al.   Nature Communications

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

(2011) A. M. Martin-Moreno et al.   MOLECULAR PHARMACOLOGY

Worsening of Huntington disease phenotype in CB1 receptor knockout mice

(2011) Stéphane Mievis et al.   NEUROBIOLOGY OF DISEASE

Zinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory

(2011) C. Sindreu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice

(2010) Remo C. Russo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease

(2010) F. M. Ribeiro et al.   JOURNAL OF NEUROSCIENCE

Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation

(2010) Alexander A Nicodemo et al.   Molecular Brain

WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

(2009) David A. Price et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effects of Positive Allosteric Modulators on Single-Cell Oscillatory Ca2+ Signaling Initiated by the Type 5 Metabotropic Glutamate Receptor

(2009) S. J. Bradley et al.   MOLECULAR PHARMACOLOGY

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

ERK activation in axonal varicosities modulates presynaptic plasticity in the CA3 region of the hippocampus through synapsin I

(2009) H. Vara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation

(2008) J. A. Ronesi et al.   JOURNAL OF NEUROSCIENCE

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

(2008) István Katona et al.   NATURE MEDICINE

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA