Article
Medicine, General & Internal
Jun T. Park, Sarah J. DeLozier, Harry T. Chugani
Summary: This study retrospectively studied 321 children with traumatic brain injury (TBI) and found that children with epilepsy due to mild TBI are more likely to have normal head computed tomography (HCT) and EEG results, and to be on 0-1 antiepileptic drug (AED).
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Chung-Che Lu, Tee-Tau Eric Nyam, Chung-Han Ho, Jinn-Rung Kuo, Chung-Ching Chio, Jhi-Joung Wang, Che-Chuan Wang
Summary: This study found that moderate/severe TBI patients had a higher mortality rate and shorter time interval from TBI to death compared to mild TBI patients. There were no significant differences in cancer incidence and risk factors for mortality between mild and moderate/severe TBI patients. However, patients aged between 46 and 55 years, female patients, and patients with pre-existing renal disease had a significantly higher cancer incidence risk in moderate/severe TBI compared with mild TBI patients.
Article
Clinical Neurology
Juho Laaksonen, Ville Ponkilainen, Ilari Kuitunen, Julius Mottonen, Ville M. Mattila
Summary: pTBI increases the risk of posttraumatic epilepsy for many years after the initial trauma. Children who undergo operative management for pTBI have a high risk for developing epilepsy, especially within the first 4 years after the injury.
Review
Immunology
Laura N. Verboon, Hiren C. Patel, Andrew D. Greenhalgh
Summary: Mild traumatic brain injury (mild TBI) is the most common form of TBI and can lead to emotional and neurocognitive disorders, as well as neurodegenerative conditions later in life. Immune cells are believed to play a key role in the pathogenesis of these diseases and mood disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shalini Das Gupta, Robert Ciszek, Mette Heiskanen, Niina Lapinlampi, Janne Kukkonen, Ville Leinonen, Noora Puhakka, Asla Pitkanen
Summary: The study identified plasma miR-9-3p and miR-136-3p as promising biomarker candidates for mTBI, showing potential for distinguishing mTBI patients with high sensitivity and specificity. Further validation in a larger patient population is needed to confirm their diagnostic utility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Carmen Munoz-Ballester, Dzenis Mahmutovic, Yusuf Rafiqzad, Alia Korot, Stefanie Robel
Summary: This study using a mouse model of mTBI found that exposure of neurons to blood-borne factors causes a rapid and sustained loss of neuronal proteins and changes in spine morphology, without neurodegeneration, which may be relevant to many neuropathologies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Christina Cherian, Juan P. Appendino, Setareh Ashtiani, Paolo Federico, Christine P. Molnar, Marina Kerr, Aneal Khan, Ping Yee Billie Au, Karl Martin Klein
Summary: This study reported a KCNT1 family with a wide spectrum of phenotypes, ranging from developmental and epileptic encephalopathy to atypical frontal lobe epilepsy. The findings suggest that pathogenic variants in KCNT1 can be associated with mild epilepsy and should not be excluded during variant interpretation solely based on gene-disease associations.
JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pedro Andrade, Leonardo Lara-Valderrabano, Eppu Manninen, Robert Ciszek, Jesse Tapiala, Xavier Ekolle Ndode-Ekane, Asla Pitkanen
Summary: This study demonstrated that seizure susceptibility increases over weeks-months after traumatic brain injury in rats, and this susceptibility predicts the development of post-traumatic epilepsy or epileptiform activity. The study also found that rats develop chronic sleep disturbance after TBI, and some sleep parameters can serve as novel biomarkers for the development of post-traumatic epileptogenesis.
Article
Clinical Neurology
Biayna Sukhudyan, Krasimir Minkin, Sevak Badalyan, Kaloyan Gabrovski, Ani Gevorgyan, Irina Tovmasyan, Ara Babloyan, Petia Dimova
Summary: We present our experience with the national epilepsy surgery program in Armenia by tracing the development of epilepsy surgery in the largest pediatric neurology department at Arabkir Medical Center. This development was possible on the basis of a strong collaboration with the Epilepsy Surgery center at the University Hospital Sofia St. Ivan Rilski, Sofia, Bulgaria.
FRONTIERS IN NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Emilie Isager Howe, Marina Zeldovich, Nada Andelic, Nicole von Steinbuechel, Silje C. R. Fure, Ida M. H. Borgen, Marit Forslund, Torgeir Hellstrom, Helene L. Soberg, Unni Sveen, Mari Rasmussen, Ingerid Kleffelgaard, Cathrine Tverdal, Eirik Helseth, Marianne Lovstad, Juan Lu, Juan Carlos Arango-Lasprilla, Olli A. Tenovuo, Philippe Azouvi, Helen Dawes, Cecilie Roe
Summary: This study aimed to investigate the provision of rehabilitation services and factors associated with outcomes in patients with mild traumatic brain injury (mTBI). The study found that patients with complicated mTBI reported more unfavorable outcomes and received rehabilitation services more frequently. Receiving rehabilitation services and a higher number of care transitions were indicators of injury severity and associated with unfavorable outcomes.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Emergency Medicine
Jacob K. Greenberg, Ranbir Ahluwalia, Madelyn Hill, Gabbie Johnson, Andrew T. Hale, Ahmed Belal, Shawyon Baygani, Margaret A. Olsen, Randi E. Foraker, Christopher R. Carpenter, Yan Yan, Laurie Ackerman, Corina Noje, Eric Jackson, Erin Burns, Christina M. Sayama, Nathan R. Selden, Shobhan Vachhrajani, Chevis N. Shannon, Nathan Kuppermann, David D. Limbrick
Summary: The KIIDS-TBI model has high sensitivity and moderate specificity for risk stratifying children with mTBI and intracranial injuries, which can help improve the safe and resource-efficient management of this important patient population.
ACADEMIC EMERGENCY MEDICINE
(2021)
Article
Neurosciences
Maha Tabet, Marya El-Kurdi, Muhammad Ali Haidar, Leila Nasrallah, Mohammad Amine Reslan, Deborah Shear, Jignesh D. Pandya, Ahmed F. El-Yazbi, Mirna Sabra, Stefania Mondello, Yehia Mechref, Abdullah Shaito, Kevin K. Wang, Riyad El-Khoury, Firas Kobeissy
Summary: Traumatic brain injury (TBI) is a common and serious condition that leads to disability and death. Mild TBI (mTBI) represents the majority of cases, and repeated exposure to mTBI (rmTBI) can worsen symptoms. However, there is currently no approved drug for TBI or rmTBI. This study aimed to investigate the potential use of a mitochondria-targeted antioxidant, MitoQ, as a neurotherapy for rmTBI. The findings suggest that MitoQ can improve motor function and learning impairments caused by rmTBI, reduce inflammation, and increase antioxidant enzyme expression.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Sloka S. Iyengar, Laura Lubbers, Lauren Harte-Hargrove
Summary: Post-traumatic epilepsy is an acquired epilepsy that develops after traumatic brain injury. It can cause personal, financial, and societal burden. Current treatments are only partially effective and often have adverse side effects. The research on post-traumatic epilepsy has expanded, but challenges in identifying effective prevention and treatment strategies remain.
Article
Critical Care Medicine
Bailey Whitehead, Ruth Velazquez-Cruz, Ali Albowaidey, Ning Zhang, Kate Karelina, Zachary M. Weil
Summary: Mild traumatic brain injury (mTBI) leads to persistent cerebrovascular impairments and increased susceptibility to ischemic stroke. The mechanisms behind these effects differ between males and females.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Pharmacology & Pharmacy
Jason D. Vadhan, Robert C. Speth
Summary: This review discusses how activation of the brain RAS following TBI contributes to permanent brain damage, and how drugs that counteract activation of the AT(1)R can potentially ameliorate TBI-induced brain damage.
PHARMACOLOGY & THERAPEUTICS
(2021)
