Involvement of molecular chaperone in protein-misfolding brain diseases

Interweaving epilepsy and neurodegeneration: Vitamin E as a treatment approach

(2021) Aman B. Upaganlawar et al.   BIOMEDICINE & PHARMACOTHERAPY

Interweaving of reactive oxygen species and major neurological and psychiatric disorders

(2021) M.D. Umare et al.   ANNALES PHARMACEUTIQUES FRANCAISES

Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases

(2020) Jessica Tittelmeier et al.   Frontiers in Aging Neuroscience

Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats

(2020) Manish M. Aglawe et al.   BRAIN RESEARCH BULLETIN

Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease

(2019) Masoomeh Khalifeh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

(2018) Franziska Kundel et al.   ACS Chemical Biology

PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5

(2018) Dae-Hee Lee et al.   Autophagy

Paraquat-induced inflammatory response of microglia through HSP60/TLR4 signaling

(2018) Y Sun et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

(2018) Hannah E. R. Baughman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70–Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation

(2018) Anatoli B. Meriin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A switch point in the molecular chaperone Hsp90 responding to client interaction

(2018) Daniel Andreas Rutz et al.   Nature Communications

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids

(2017) Lorena De Mena et al.   FLY

The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis

(2017) Hyoung Tae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex ( CubipyOXA ) leads to cell death in NCI-H292 cancer cells

(2017) Celeste Caruso Bavisotto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

(2016) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Alzheimer's Disease and Molecular Chaperones: Current Knowledge and the Future of Chaperonotherapy

(2016) Antonella Marino Gammazza et al.   CURRENT PHARMACEUTICAL DESIGN

The formation, function and regulation of amyloids: insights from structural biology

(2016) M. Landreh et al.   JOURNAL OF INTERNAL MEDICINE

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

(2016) Martin Ingelsson   Frontiers in Neuroscience

Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?

(2015) Thomas A. Bayer   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Functional roles of transiently and intrinsically disordered regions within proteins

(2015) Vladimir N. Uversky   FEBS Journal

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

(2015) Hyunjoo Cha-Molstad et al.   NATURE CELL BIOLOGY

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

Advances in Therapeutics for Neurodegenerative Tauopathies: Moving toward the Specific Targeting of the Most Toxic Tau Species

(2014) Julia E. Gerson et al.   ACS Chemical Neuroscience

C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration

(2014) Stephanie May et al.   ACTA NEUROPATHOLOGICA

Ubiquilin 2: A component of the ubiquitin–proteasome system with an emerging role in neurodegeneration

(2014) Katharine Y. Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structure of Transmembrane Domain of Lysosome-associated Membrane Protein Type 2a (LAMP-2A) Reveals Key Features for Substrate Specificity in Chaperone-mediated Autophagy

(2014) Ashok K. Rout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2014) Tiago Fleming Outeiro et al.   PLoS One

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

(2014) Panchanan Maiti et al.   Biomed Research International

On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis

(2013) Michael A. Castello et al.   AGEING RESEARCH REVIEWS

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2

(2013) Martin Schwalbe et al.   BIOCHEMISTRY

Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

(2013) Aaron Ciechanover   BIOORGANIC & MEDICINAL CHEMISTRY

Impurities preparation of sodium tanshinone IIA sulfonate by high-speed counter-current chromatography and identification by liquid chromatography/multistage tandem mass spectrometry

(2013) Shanqiao Chen et al.   JOURNAL OF CHROMATOGRAPHY A

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

Molecular Chaperone Mediated Late-Stage Neuroprotection in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2013) Sergey S. Novoselov et al.   PLoS One

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

(2012) John Labbadia et al.   BRAIN

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid

(2012) Ken Carlson Walls et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins

(2012) Yufeng Jiang et al.   NEUROSCIENCE LETTERS

Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis

(2012) Masaoki Takano et al.   NEUROSCIENCE LETTERS

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

(2012) B. Mannini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation

(2011) Sarah L. Shammas et al.   BIOPHYSICAL JOURNAL

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

(2011) Karin Wirdefeldt et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics

(2011) Umesh K. Jinwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

(2011) T. Hoshino et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Large Potentials of Small Heat Shock Proteins

(2011) Evgeny V. Mymrikov et al.   PHYSIOLOGICAL REVIEWS

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of α-synuclein aggregation by small heat shock proteins

(2011) Ilona B. Bruinsma et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Heat Shock Proteins: Cell Protection through Protein Triage

(2011) David Lanneau et al.   TheScientificWorldJOURNAL

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

Collective Roles of Molecular Chaperones in Protein Degradation Pathways Associated with Neurodegenerative Diseases

(2010) Guang Luo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones

(2010) Michel J. Vos et al.   HUMAN MOLECULAR GENETICS

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

(2010) Nadinath B. Nillegoda et al.   MOLECULAR BIOLOGY OF THE CELL

A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation

(2010) Jurre Hageman et al.   MOLECULAR CELL

Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways

(2010) Peter M. Douglas et al.   Prion

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

(2010) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance

(2010) Samantha J. Orenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets

(2009) Vladimir Kirkin et al.   Autophagy

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Biophysics of Parkinsons Disease: Structure and Aggregation of α- Synuclein

(2009) Vladimir Uversky et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

β-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure

(2009) Jorge Parodi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Chaperone Hsp90 Modulates Intermediate Steps of Amyloid Assembly of the Parkinson-related Protein α-Synuclein

(2009) S. Fabio Falsone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

(2009) J. L. Wacker et al.   JOURNAL OF NEUROSCIENCE

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

(2009) Ashwani K Thakur et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of α-synuclein in an aggregation prone state

(2009) Min-Kyu Cho et al.   PROTEIN SCIENCE

Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones

(2009) Daniel W. Summers et al.   TRENDS IN BIOCHEMICAL SCIENCES

Interactions between Hsp70 and the Hydrophobic Core of α-Synuclein Inhibit Fibril Assembly†

(2008) Kelvin C. Luk et al.   BIOCHEMISTRY

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Protein misfolding and disease: from the test tube to the organism

(2008) Leila M Luheshi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor

(2008) Tomoyuki Yamanaka et al.   EMBO JOURNAL

Classification and diagnosis of dementia: a mechanism-based approach

(2008) M. Emre   EUROPEAN JOURNAL OF NEUROLOGY

Novel suppressors of α-synuclein toxicity identified using yeast

(2008) Jun Liang et al.   HUMAN MOLECULAR GENETICS

Chaperone signalling complexes in Alzheimer's disease

(2008) John Koren et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

(2008) Christophe Lo Bianco et al.   JOURNAL OF CLINICAL INVESTIGATION

Controlling the mass action of α-synuclein in Parkinson’s disease

(2008) Changyoun Kim et al.   JOURNAL OF NEUROCHEMISTRY

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

(2007) Paul S. Sharp et al.   NEUROBIOLOGY OF DISEASE