Hsp70–Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits

(2016) Quentin Defenouillère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

(2016) Massimo Ganassi et al.   MOLECULAR CELL

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer

(2015) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

(2014) Melania Minoia et al.   Autophagy

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

(2014) Teresa A. Colvin et al.   CANCER RESEARCH

14-3-3 and aggresome formation: Implications in neurodegenerative diseases

(2014) Baohui Jia et al.   Prion

Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex

(2014) Dmitry Lyumkis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

(2014) Ignacio Izeddin et al.   eLife

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes

(2013) Z. Xu et al.   JOURNAL OF CELL SCIENCE

Nutrient Signaling in Protein Homeostasis: An Increase in Quantity at the Expense of Quality

(2013) C. S. Conn et al.   Science Signaling

Less is more: improving proteostasis by translation slow down

(2013) Michael Y. Sherman et al.   TRENDS IN BIOCHEMICAL SCIENCES

The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype

(2012) Geunwon Kim et al.   AGING CELL

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

A Novel Approach to Recovery of Function of Mutant Proteins by Slowing Down Translation

(2012) Anatoli B. Meriin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation

(2012) A. B. Meriin et al.   JOURNAL OF CELL SCIENCE

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes

(2011) Xingqian Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

(2011) Marta del Alamo et al.   PLOS BIOLOGY

The stress-inducible HspB8-Bag3 complex induces the eIF2α kinase pathway: Implications for protein quality control and viral factory degradation?

(2009) Serena Carra   Autophagy

Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

(2008) Yan Wang et al.   FASEB JOURNAL

Triggering Aggresome Formation

(2008) Nava Zaarur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Protein Aggregate Handling and Clearance Underlie the Pathogenesis of p97/VCP-associated Disease

(2008) Jeong-Sun Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY