αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion

Mechanisms of Resistance to Immune Checkpoint Blockade

(2018) David Liu et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors

(2018) Valerio Leoni et al.   PLoS Pathogens

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Exploring the Role of RGD-Recognizing Integrins in Cancer

(2017) Markus Nieberler et al.   Cancers

αvβ3 Integrin and tumour blood vessels—learning from the past to shape the future

(2016) Fevzi Demircioglu et al.   CURRENT OPINION IN CELL BIOLOGY

Pharmacotherapies for the treatment of glioblastoma – current evidence and perspectives

(2016) Katharina Seystahl et al.   EXPERT OPINION ON PHARMACOTHERAPY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Regulation of PD-L1: a novel role of pro-survival signalling in cancer

(2015) J. Chen et al.   ANNALS OF ONCOLOGY

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma

(2015) Patcharee Ritprajak et al.   ORAL ONCOLOGY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

Dynamic control of type I IFN signalling by an integrated network of negative regulators

(2015) Rebecca A. Porritt et al.   TRENDS IN IMMUNOLOGY

Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-κB

(2015) Kavitha Gowrishankar et al.   PLoS One

TLR4 Activation Enhances the PD-L1–Mediated Tolerogenic Capacity of Colonic CD90+Stromal Cells

(2014) Ellen J. Beswick et al.   JOURNAL OF IMMUNOLOGY

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

(2014) Laetitia Seguin et al.   NATURE CELL BIOLOGY

Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin

(2014) Johannes F Van Agthoven et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Epithelial αvβ3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components

(2014) Tatiana Gianni et al.   PLoS Pathogens

Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures

(2013) Elisa Carra et al.   CELL CYCLE

Type I Interferon and NF- B Activation Elicited by Herpes Simplex Virus gH/gL via  v 3 Integrin in Epithelial and Neuronal Cell Lines

(2013) T. Gianni et al.   JOURNAL OF VIROLOGY

siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells

(2012) ANNA NASULEWICZ-GOLDEMAN et al.   ONCOLOGY REPORTS

 v 3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1

(2012) T. Gianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Cross-talk between Epidermal Growth Factor Receptor and Integrin αvβ5 Promotes Carcinoma Cell Invasion and Metastasis

(2009) Jill M. Ricono et al.   CANCER RESEARCH

Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma

(2009) Q. Gao et al.   CLINICAL CANCER RESEARCH

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Cilengitide: an integrin-targeting arginine–glycine–aspartic acid peptide with promising activity for glioblastoma multiforme

(2008) David A Reardon et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family

(2008) H. Michael Shepard et al.   JOURNAL OF CLINICAL INVESTIGATION