Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer

(2020) Aimy Sebastian et al.   Cancers

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer

(2019) Jorge Blando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

(2019) Monika Lodyga et al.   Science Signaling

Interactions between cadherin-11 and platelet-derived growth factor receptor-alpha signaling link cell adhesion and proliferation

(2019) Bhanupriya Madarampalli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations

(2018) Zishuo I. Hu et al.   CLINICAL CANCER RESEARCH

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

(2018) Claire Vennin et al.   GASTROENTEROLOGY

Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update

(2018) Davendra P.S. Sohal et al.   JOURNAL OF CLINICAL ONCOLOGY

Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes

(2017) Sook Kyung Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development

(2017) Nivedita M. Ratnam et al.   JOURNAL OF CLINICAL INVESTIGATION

Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer

(2017) Jung-Eun Jang et al.   Cell Reports

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells

(2017) Michael W. Pickup et al.   Cancer Immunology Research

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma

(2017) Ingunn M. Stromnes et al.   Cancer Immunology Research

Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer

(2016) Srinivasa P Pothula et al.   BRITISH JOURNAL OF CANCER

Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics

(2016) Sindhu Row et al.   JOURNAL OF CELL SCIENCE

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer

(2016) Lucia D’Amico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues

(2016) Qing Chang et al.   Scientific Reports

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

B cells responses and cytokine production are regulated by their immune microenvironment

(2015) Monica I. Vazquez et al.   CYTOKINE

Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation

(2015) Caitlin J. Bowen et al.   DEVELOPMENTAL BIOLOGY

Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis

(2015) Matthias Sendler et al.   GASTROENTEROLOGY

IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway

(2015) Kentaro Sumida et al.   Scientific Reports

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies.

(2015) Shahin Assefnia et al.   Oncotarget

Interleukin 1α Sustains the Expression of Inflammatory Factors in Human Pancreatic Cancer Microenvironment by Targeting Cancer-Associated Fibroblasts

(2015) Vegard Tjomsland et al.   NEOPLASIA

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Inhibition of Endoglin-GIPC Interaction Inhibits Pancreatic Cancer Cell Growth

(2014) K. Pal et al.   MOLECULAR CANCER THERAPEUTICS

Clinical impact of pentraxin family expression on prognosis of pancreatic carcinoma

(2013) S Kondo et al.   BRITISH JOURNAL OF CANCER

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

(2013) Tracy L. Putoczki et al.   CANCER CELL

Monoclonal Antibody against the Ectodomain of E-Cadherin (DECMA-1) Suppresses Breast Carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP Pathways

(2013) S. M. Brouxhon et al.   CLINICAL CANCER RESEARCH

Inflammatory networks and immune surveillance of pancreatic carcinoma

(2013) Robert H Vonderheide et al.   CURRENT OPINION IN IMMUNOLOGY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Cadherin 11 as a Mediator of Dermal Fibrosis and Possible Role in Systemic Sclerosis

(2013) Minghua Wu et al.   Arthritis & Rheumatology

Home Sweet Home: The Tumor Microenvironment as a Haven for Regulatory T Cells

(2013) Beatrice Ondondo et al.   Frontiers in Immunology

Selective Expansion of Allogeneic Regulatory T Cells by Hepatic Stellate Cells: Role of Endotoxin and Implications for Allograft Tolerance

(2012) A. Dangi et al.   JOURNAL OF IMMUNOLOGY

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

(2011) Daniel J. Schneider et al.   FASEB JOURNAL

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cadherin-11 regulates fibroblast inflammation

(2011) S. K. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

(2009) Huadong Pei et al.   CANCER CELL

C-reactive protein (CRP) increases VEGF-A expression in monocytic cells via a PI3-kinase and ERK 1/2 signaling dependent pathway

(2008) Gaëlle Bello et al.   ATHEROSCLEROSIS

Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients

(2008) Mei Tian et al.   BMC CANCER

Modulation of the antitumor immune response by complement

(2008) Maciej M Markiewski et al.   NATURE IMMUNOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY