Article
Immunology
Qian Wang, Zhenzhen Sun, Shihan Cao, Xiuli Lin, Mengying Wu, Yuanyuan Li, Jie Yin, Wei Zhou, Songming Huang, Aihua Zhang, Yue Zhang, Weiwei Xia, Zhanjun Jia
Summary: The study reveals the involvement of MAVS in cardiac dysfunction, showing reduced MAVS expression in non-hypertrophic cardiac dysfunction and enhanced MAVS expression in hypertrophic heart. MAVS deficiency leads to cardiac dysfunction, mitochondrial impairment, and disturbed energy metabolism. These findings suggest a crucial role of MAVS in the pathogenesis of non-hypertrophic cardiac dysfunction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Ghulam Abbas, Mengmeng Cui, Dianbing Wang, Min Li, Xian-En Zhang
Summary: This study developed subcellular compartment-specific sensors to monitor GSH/GSSG levels in AML cells and revealed substantial heterogeneity of GSH/GSSG level dynamics in different subcellular compartments. The study also showed that certain drugs downregulated GSH/GSSG levels in different subcellular compartments, suggesting potential therapeutic targets in AML cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chang-Chun Song, Kostas Pantopoulos, Guang-Hui Chen, Chong-Chao Zhong, Tao Zhao, Dian-Guang Zhang, Zhi Luo
Summary: In this study, it was found that a high-iron diet increased intestinal iron content and promoted lipid deposition. This phenomenon was mediated by the HIF1α-PPARγ pathway, involving oxidative stress and mitochondrial dysfunction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Denise Sighel, Michela Notarangelo, Shintaro Aibara, Angela Re, Gianluca Ricci, Marianna Guida, Alessia Soldano, Valentina Adami, Chiara Ambrosini, Francesca Broso, Emanuele Filiberto Rosatti, Sara Longhi, Mariachiara Buccarelli, Quintino G. D'Alessandris, Stefano Giannetti, Simone Pacioni, Lucia Ricci-Vitiani, Joanna Rorbach, Roberto Pallini, Sandrine Roulland, Alexey Amunts, Ines Mancini, Angelika Modelska, Alessandro Quattrone
Summary: This study suggests that targeting mitochondrial translation could be a potential therapeutic strategy to suppress GSC growth in GBM. The bacterial antibiotic quinupristin/dalfopristin (Q/D) was found to effectively inhibit GSC growth by binding to the large mitoribosomal subunit, inhibiting mitochondrial protein synthesis, and disrupting OXPHOS complexes.
Article
Biochemistry & Molecular Biology
Shih-Yuan Hsu, Zhi-Hong Wen, Po-Chang Shih, Hsiao-Mei Kuo, Sung-Chun Lin, Hsin-Tzu Liu, Yi-Hsin Lee, Yi-Jen Wang, Wu-Fu Chen, Nan-Fu Chen
Summary: This study evaluated the effects of sinularin, a marine-derived product, on glioblastoma multiforme (GBM). The results showed that sinularin can induce cell death in GBM cells and inhibit angiogenesis. These findings suggest that sinularin may be a potential drug for treating GBM.
Article
Biochemistry & Molecular Biology
Debora da Luz Scheffer, Adriana Ann Garcia, Lucia Lee, Daria Mochly-Rosen, Julio Cesar Batista Ferreira
Summary: Mitochondria are crucial to heart physiology, but accumulation of damaged mitochondria is a characteristic of cardiac diseases. Disruption of quality control systems leads to dysfunctional mitochondria, impaired cardiac bioenergetics, and oxidative stress. Pharmacological tools have emerged to improve the cardiac pool of healthy mitochondria, but clinical studies are needed to validate their effectiveness.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Iveta Fizikova, Jozef Dragasek, Peter Racay
Summary: The complexity of the brain can lead to the development of serious neuropsychiatric disorders, such as schizophrenia. The etiopathogenesis of schizophrenia involves multiple mechanisms, highlighting its complexity and providing a new perspective for studying this disorder. This review focuses on the contribution of mitochondria, particularly oxidative damage, ROS, and energy metabolism. It also discusses the role of redox imbalance and lactate in oxidative stress, lipid peroxidation, and cognitive functions in schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Ecology
Rebecca E. Koch, Katherine L. Buchanan, Stefania Casagrande, Ondi Crino, Damian K. Dowling, Geoffrey E. Hill, Wendy R. Hood, Matthew McKenzie, Mylene M. Mariette, Daniel W. A. Noble, Alexandra Pavlova, Frank Seebacher, Paul Sunnucks, Eve Udino, Craig R. White, Karine Salin, Antoine Stier
Summary: The critical role that energy turnover plays in understanding variation in performance and fitness among individuals has long been recognized by biologists. While whole-organism metabolic studies have provided key insights into ecological and evolutionary processes, constraints at subcellular levels, such as within mitochondria, can also optimize metabolism. This exploration of mitochondrial aerobic metabolism's influence on organismal performance highlights important areas for future research in understanding ecological and evolutionary processes.
TRENDS IN ECOLOGY & EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Fan Li, Xiaojing Wu, Hongli Liu, Mengqi Liu, Zhengkai Yue, Zhenyu Wu, Lei Liu, Fuchang Li
Summary: This study reveals that copper depletion enhances ferroptosis by causing mitochondrial perturbation and reducing antioxidative mechanisms.
Review
Pharmacology & Pharmacy
Chennan Wu, Zhen Zhang, Weidong Zhang, Xia Liu
Summary: Cardiovascular diseases, including heart failure, are leading causes of death globally. Despite advancements in therapies, life expectancy for heart failure remains poor. Targeting mitochondrial dysfunction, which is closely related to heart failure, may be an effective approach for treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Catarina M. Quinzii, Luis C. Lopez
Summary: Mitochondrial disorders are genetic diseases with inadequate therapy due to the heterogeneity and tissue-specificity of pathomechanisms. Abnormalities in hydrogen sulfide (H2S) metabolism are emerging as a novel mechanism in mitochondrial dysfunction, but further studies are needed to understand the effects and relevance in mitochondrial diseases. The review focuses on derangement of H2S metabolism in primary Coenzyme Q (CoQ) deficiency and emphasizes the need for more research on the consequences of abnormalities in H2S and GSH synthesis on the oxidation pathway.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Mao Xie, Huixian Wu, Jing Bian, Shutong Huang, Yuanzheng Xia, Yujun Qin, Zhiming Yan
Summary: This study designed and synthesized a series of capsaicin analogues and found that some of them exhibited stronger antioxidant activity than quercetin. Among the compounds, the representative compound 3k showed great protective effects against H2O2-induced oxidative damage at low concentrations, reduced intracellular ROS accumulation, increased GSH levels, and improved mitochondrial membrane potential in SY5Y cells treated with H2O2, thus playing a role in preventing neuronal cell death.
Article
Multidisciplinary Sciences
Shixuan Zhang, Junrou Zhang, Luli Wu, Li Chen, Piye Niu, Jie Li
Summary: Excessive exposure to manganese can cause neurological abnormalities, but the mechanism of Mn neurotoxicity remains unclear. Abnormal mitochondrial metabolism and inhibition of the glutathione metabolic pathway are key factors underlying Mn-induced neurotoxicity. Supplementation with glutamine can increase glutathione concentration and trigger mitochondrial unfolded protein response, alleviating mitochondrial dysfunction and counteracting the neurotoxicity of Mn.
Article
Endocrinology & Metabolism
Nicole K. H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. Mccommis, Brian N. Finck, Mitchell R. Mcgill
Summary: This study demonstrates that MPC inhibition sensitizes the liver to APAP-induced injury only in the absence of ALT2. Liver-specific double knockout of MPC2 and ALT2 significantly worsens APAP-induced liver damage. The induction of ALT2 and posttreatment with dichloroacetate reduce APAP-induced liver injury.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Wenfei Yu, Zhuxun Li, Wenjing Wu, Dandan Zhao, Chuanzhu Yan, Pengfei Lin
Summary: This study investigated the mechanisms underlying telbivudine-induced myopathy and found that it is associated with mitochondrial toxicity and impaired energy metabolism. This provides evidence supporting the common mechanism of NAs causing neuromyopathy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Shuai Zhang, Hao Sheng, Xiaoya Zhang, Qi Qi, Chi Bun Chan, Leilei Li, Changliang Shan, Keqiang Ye
CELL DEATH & DISEASE
(2019)
Article
Chemistry, Medicinal
Ke Huang, Lulu Jiang, Ronghui Liang, Huiti Li, Xiaoxue Ruan, Changliang Shan, Deyong Ye, Lu Zhou
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Yanping Li, Ronghui Liang, Xiaoya Zhang, Jiyan Wang, Changliang Shan, Shuangping Liu, Leilei Li, Shuai Zhang
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Chemistry, Medicinal
Zhongyuan Luo, Daohai Du, Yanjun Liu, Tian Lu, Liping Liu, Hualiang Jiang, Kaixian Chen, Changliang Shan, Cheng Luo
Summary: A new high-throughput screening method was developed to discover G6PD inhibitors, with Wedelolactone identified as a strong inhibitor in a non-competitive, reversible manner, as confirmed by surface Plasmon Resonance assay. The study also showed the inhibitory effect of Wedelolactone on ovarian cancer cell proliferation through targeting G6PD.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Lin Chen, Na Li, Meiqi Zhang, Mingming Sun, Jiaxuan Bian, Bo Yang, Zhengcunxiao Li, Jiayu Wang, Fei Li, Xiaomeng Shi, Yuan Wang, Feng Yuan, Peng Zou, Changliang Shan, Jing Wang
Summary: A previously unrecognized nuclear copper binding protein, CRIP2, was identified and shown to play a crucial role in copper transfer and protein degradation, ultimately activating autophagy in cancer cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medicine, General & Internal
Yu Yuan, Chenxin Yang, Yingzhi Wang, Mingming Sun, Chenghao Bi, Sitong Sun, Guijiang Sun, Jingpeng Hao, Lingling Li, Changliang Shan, Shuai Zhang, Yubo Li
Summary: This study aimed to compare the metabolic differences between CRC patients and healthy controls and identify potential biomarkers for early diagnosis and targeted therapy. The findings revealed that glycodeoxycholic acid (GDCA) in serum was positively correlated with CRC and could serve as a molecular biomarker. In vitro experiments showed that GDCA promoted the proliferation and migration of CRC cells, and it was identified that GDCA targeted Poly(ADP-ribose) polymerase-1 (PARP-1).
Article
Biochemistry & Molecular Biology
Jiyan Wang, Yaya Qiao, Huanran Sun, Hongkai Chang, Huifang Zhao, Shuai Zhang, Changliang Shan
Summary: Tyrosine is an essential amino acid involved in the metabolism of proteins, lipids, and carbohydrates. Down-regulation of tyrosine-metabolizing enzymes in hepatocellular carcinoma (HCC) is associated with a poor prognosis. Reduced tyrosine metabolism activates the cell cycle and promotes cell proliferation.
Review
Biology
Jiaqi Song, Huanran Sun, Shuai Zhang, Changliang Shan
Summary: The pentose phosphate pathway (PPP) is an important metabolic pathway that provides crucial substances such as NADPH and nucleotides for cellular activities. G6PD, the rate-limiting enzyme of PPP, is upregulated in various cancers and its dysfunction influences cancer cell growth, invasion, and chemotherapeutic resistance. Targeting G6PD has shown promise as a strategy in treating cancer and reversing chemoresistance.
Article
Biochemistry & Molecular Biology
Jiyan Wang, Hongkai Chang, Meng Su, Yaya Qiao, Huanran Sun, Yongshan Zhao, Shuai Zhang, Changliang Shan
Summary: Kidney renal clear cell carcinoma (KIRC) is the most common subtype of renal cell carcinoma, with a poor prognosis. In this study, we identified the biomarkers HGD and GSTZ1 related to the prognosis of KIRC through bioinformatics analysis. We found that they regulate the metabolism and energy balance of tumor cells, promoting tumor progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mingming Sun, Leilei Li, Yujia Niu, Yingzhi Wang, Qi Yan, Fei Xie, Yaya Qiao, Jiaqi Song, Huanran Sun, Zhen Li, Sizhen Lai, Hongkai Chang, Han Zhang, Jiyan Wang, Chenxin Yang, Huifang Zhao, Junzhen Tan, Yanping Li, Shuangping Liu, Bin Lu, Min Liu, Guangyao Kong, Yujun Zhao, Chunze Zhang, Shu-Hai Lin, Cheng Luo, Shuai Zhang, Changliang Shan
Summary: PRMT6 is highly expressed in lung cancer and regulates glucose metabolism. It methylates 6PGD and ENO1 to enhance their activities, affecting the oxidative PPP flux and glycolysis pathway. Targeting PRMT6 inhibits tumor growth, blocks glucose metabolism, and enhances the anti-tumor effects of cisplatin.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Oncology
Jiyan Wang, Yaya Qiao, Mingming Sun, Huanran Sun, Fei Xie, Hongkai Chang, Yingzhi Wang, Jiaqi Song, Sizhen Lai, Chenxin Yang, Xichuan Li, Shuangping Liu, Xuanzhu Zhao, Kemin Ni, Kewei Meng, Shuai Zhang, Changliang Shan, Chunze Zhang
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Taoyuan Wang, Tiansheng Tang, Youguo Jiang, Tao He, Luyu Qi, Hongkai Chang, Yaya Qiao, Mingming Sun, Changliang Shan, Xinyuan Zhu, Jianshi Liu, Jiyan Wang
Summary: p53 mutations are common in human cancer, and in this study, it was found that elevated expression of PRIM2 in p53-mutated lung cancer is associated with tumor progression. The expression of PRIM2 is regulated by p53 and serves as a biomarker for lung cancer malignancy and survival prognosis.
Article
Biochemistry & Molecular Biology
Mingming Sun, Qi Yan, Yaya Qiao, Huifang Zhao, Yingzhi Wang, Changliang Shan, Shuai Zhang
Summary: PIKE-A promotes cancer cell proliferation by regulating mitochondrial membrane potential through the STAT3/FTO/SDHA axis, providing a novel target for anti-cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Jiyan Wang, Xintong Dai, Hongkai Chang, Qingle Gao, Jianshuang Guo, Juze Yang, Shuai Zhang, Changliang Shan
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)