Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation

AMPK: guardian of metabolism and mitochondrial homeostasis

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Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression

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Down-regulation of 14-3-3β exerts anti-cancer effects through inducing ER stress in human glioma U87 cells: Involvement of CHOP–Wnt pathway

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Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity

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Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

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Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction

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14-3-3β regulates the proliferation of glioma cells through the GSK3β/β-catenin signaling pathway

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Tools for protein-protein interaction network analysis in cancer research

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Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation

(2012) Q Qi et al.   ONCOGENE

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner

(2011) Kunyan He et al.   MOLECULAR BIOLOGY OF THE CELL

PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development

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Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship

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Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

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GGAP2/PIKE-A Directly Activates Both the Akt and Nuclear Factor- B Pathways and Promotes Prostate Cancer Progression

(2009) Y. Cai et al.   CANCER RESEARCH

Arf GTPase-activating Protein AGAP2 Regulates Focal Adhesion Kinase Activity and Focal Adhesion Remodeling

(2009) Yunjuan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

(2008) Xiaoling Tang et al.   NATURE CELL BIOLOGY

Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion

(2008) R. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

(2008) Deborah K. Morrison   TRENDS IN CELL BIOLOGY