Role of chronic neuroinflammation in neuroplasticity and cognitive function: A hypothesis

Broader Insights into Understanding Tumor Necrosis Factor and Neurodegenerative Disease Pathogenesis Infer New Therapeutic Approaches

(2021) Ian Albert Clark et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia regulate synaptic development and plasticity

(2021) Megumi Andoh et al.   Developmental Neurobiology

Targeting innate immunity to protect and cure Alzheimer’s disease: opportunities and pitfalls

(2021) Giulia Cisbani et al.   MOLECULAR PSYCHIATRY

Repurposing Immunomodulatory Imide Drugs (IMiDs) in Neuropsychiatric and Neurodegenerative Disorders

(2021) Yoo Jin Jung et al.   Frontiers in Neuroscience

3,6′-Dithiopomalidomide Ameliorates Hippocampal Neurodegeneration, Microgliosis and Astrogliosis and Improves Cognitive Behaviors in Rats with a Moderate Traumatic Brain Injury

(2021) Pen-Sen Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Landmark Alzheimer’s drug approval confounds research community

(2021) Asher Mullard   NATURE

Treatments for Alzheimer's disease emerge

(2021) Dennis J. Selkoe   SCIENCE

Alzheimer’s drugs: Does reducing amyloid work?

(2021) Madhav Thambisetty et al.   SCIENCE

In search of an anti-inflammatory drug for Alzheimer disease

(2020) Erika Gyengesi et al.   Nature Reviews Neurology

Association of traumatic brain injury with dementia and memory decline in older adults in the United States

(2020) Leslie Grasset et al.   Alzheimers & Dementia

Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis

(2020) Mengshi Zhou et al.   PLoS One

Recent advances in the molecular mechanism of thalidomide teratogenicity

(2020) Shaobing Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation

(2020) Chih-Tung Lin et al.   eLife

TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions

(2020) Stefano Raffaele et al.   Cells

Pomalidomide Reduces Ischemic Brain Injury in Rodents

(2019) Yan-Rou Tsai et al.   CELL TRANSPLANTATION

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

(2019) Dawling A. Dionisio-Santos et al.   Journal of Neuroinflammation

Molecular mechanisms of cereblon-based drugs

(2019) Tomoko Asatsuma-Okumura et al.   PHARMACOLOGY & THERAPEUTICS

The “rights” of precision drug development for Alzheimer’s disease

(2019) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Perispinal etanercept advances as a neurotherapeutic

(2018) Edward Tobinick   Expert Review of Neurotherapeutics

Microglia-Mediated Synapse Loss in Alzheimer's Disease

(2018) Lawrence Rajendran et al.   JOURNAL OF NEUROSCIENCE

Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study

(2018) Anna Nordström et al.   PLOS MEDICINE

Perispinal etanercept advances as a neurotherapeutic

(2018) Edward Tobinick   Expert Review of Neurotherapeutics

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

(2018) Mary E. Matyskiela et al.   Nature Chemical Biology

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

(2017) Benjamin M. Davis et al.   Scientific Reports

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat

(2016) Jing-Ya Wang et al.   Journal of Neuroinflammation

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice

(2015) Renana Baratz et al.   Journal of Neuroinflammation

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

The European Medicines Agency Review of Pomalidomide in Combination With Low-Dose Dexamethasone for the Treatment of Adult Patients With Multiple Myeloma: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use

(2015) Z. Hanaizi et al.   ONCOLOGIST

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

(2013) C. Mahony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

A review of the history, properties, and use of the immunomodulatory compound lenalidomide

(2011) Jerome B. Zeldis et al.   Annals of the New York Academy of Sciences

Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases

(2011) Kathryn A. Frankola et al.   CNS & Neurological Disorders-Drug Targets

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

(2011) Hakan Kucukdereli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

(2009) Cindy M Sondag et al.   Journal of Neuroinflammation

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON