Why nanoparticles prefer liver macrophage cell uptake in vivo

Targeted drug delivery strategies for precision medicines

(2021) Mandana T. Manzari et al.   Nature Reviews Materials

Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice

(2021) Yizhi Jiang et al.   CELL DEATH AND DIFFERENTIATION

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy

(2021) Marie Siwicki et al.   Science Immunology

Liposome Imaging in Optically Cleared Tissues

(2020) Abdullah Muhammad Syed et al.   NANO LETTERS

Mechanisms for cellular uptake of nanosized clinical MRI contrast agents

(2020) Emily J. Guggenheim et al.   Nanotoxicology

Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model

(2020) Lewis Y. Liu et al.   ACS Nano

Flow Rate Affects Nanoparticle Uptake into Endothelial Cells

(2020) Yih Yang Chen et al.   ADVANCED MATERIALS

The dose threshold for nanoparticle tumour delivery

(2020) Ben Ouyang et al.   NATURE MATERIALS

A Systematic comparison of in vitro cell uptake and in vivo biodistribution for three classes of gold nanoparticles with saturated PEG coatings

(2020) Yijia Zhang et al.   PLoS One

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

(2020) Yankai Wen et al.   Cellular & Molecular Immunology

Role of Liver-Mediated Tolerance in Nanoparticle-Based Tumor Therapy

(2020) Maximiliano L. Cacicedo et al.   Cells

In vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors

(2020) Aziz B. Mirkasymov et al.   JOURNAL OF CONTROLLED RELEASE

Elimination Pathways of Nanoparticles

(2019) Wilson Poon et al.   ACS Nano

Precision Nanomedicine Development Based on Specific Opsonization of Human Cancer Patient-Personalized Protein Coronas

(2019) Jiayu Ren et al.   NANO LETTERS

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

Macrophages and hepatocellular carcinoma

(2019) Zhiqiang Tian et al.   Cell and Bioscience

Overcoming the Reticuloendothelial System Barrier to Drug Delivery with a “Don’t-Eat-Us” Strategy

(2019) Yixuan Tang et al.   ACS Nano

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

(2019) Daphne van der Heide et al.   Frontiers in Immunology

Spherical Nucleic Acids with Tailored and Active Protein Coronae

(2019) Wuliang Zhang et al.   ACS Central Science

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumours

(2018) Qin Dai et al.   ACS Nano

Suggested reference values for regional blood volumes in children and adolescents

(2018) Michael B Wayson et al.   PHYSICS IN MEDICINE AND BIOLOGY

Surface-grafted polyethylene glycol conformation impacts the transport of PEG-functionalized liposomes through a tumour extracellular matrix model

(2018) Hagar I. Labouta et al.   RSC Advances

Synthesis of Patient-Specific Nanomaterials

(2018) James Lazarovits et al.   NANO LETTERS

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure

(2018) Evangelos Triantafyllou et al.   Frontiers in Immunology

Effect of inhibitors of endocytosis and NF-kB signal pathway on folate-conjugated nanoparticle endocytosis by rat Kupffer cells

(2017) Hongbo Tang et al.   International Journal of Nanomedicine

Effect of removing Kupffer cells on nanoparticle tumor delivery

(2017) Anthony J. Tavares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis

(2017) Shoichi Komine et al.   Scientific Reports

A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery

(2017) Joy Wolfram et al.   Scientific Reports

Three-Dimensional Optical Mapping of Nanoparticle Distribution in Intact Tissues

(2016) Shrey Sindhwani et al.   ACS Nano

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Liposomal Amphotericin B (AmBisome®): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions

(2016) Neil R. H. Stone et al.   DRUGS

Immunophenotypical characterization and influence on liver homeostasis of depleting and repopulating hepatic macrophages in rats injected with clodronate

(2016) Munmun Pervin et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

(2016) Lynette Beattie et al.   JOURNAL OF HEPATOLOGY

Cellular distribution of injected PLGA-nanoparticles in the liver

(2016) Jin-Kyu Park et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanism of hard-nanomaterial clearance by the liver

(2016) Kim M. Tsoi et al.   NATURE MATERIALS

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

(2016) Igor Theurl et al.   NATURE MEDICINE

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases

(2015) Matthias Bartneck et al.   BIOMATERIALS

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2015) David Gosselin et al.   CELL

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RES blockade: A strategy for boosting efficiency of nanoparticle drug

(2015) Ting Liu et al.   Nano Today

Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency

(2014) Edward A. Sykes et al.   ACS Nano

High liposomal doxorubicin tumour tissue distribution, as determined by radiopharmaceutical labelling with 99mTc-LD, is associated with the response and survival of patients with unresectable pleural mesothelioma treated with a combination of liposomal doxorubicin and cisplatin

(2014) Oscar Arrieta et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum

(2014) Annette Krais et al.   Nanomedicine-Nanotechnology Biology and Medicine

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Effect of Injection Routes on the Biodistribution, Clearance, and Tumor Uptake of Carbon Dots

(2013) Xinglu Huang et al.   ACS Nano

Multifunctional polymeric nanoparticles for oral delivery of TNF-α siRNA to macrophages

(2013) Chunbai He et al.   BIOMATERIALS

Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency

(2013) Anna Lesniak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver

(2013) Chih-Ya Yang et al.   PLoS One

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

Peptide-Functionalized Gold Nanorods Increase Liver Injury in Hepatitis

(2012) Matthias Bartneck et al.   ACS Nano

Engineering Nano- and Microparticles to Tune Immunity

(2012) James J. Moon et al.   ADVANCED MATERIALS

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages

(2012) Shann Yu et al.   International Journal of Nanomedicine

Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages

(2012) Dowty Movita et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Evaluation of Multivalent, Functional Polymeric Nanoparticles for Imaging Applications

(2011) Monica Shokeen et al.   ACS Nano

Differential Uptake of Functionalized Polystyrene Nanoparticles by Human Macrophages and a Monocytic Cell Line

(2011) Oleg Lunov et al.   ACS Nano

Effect of surface coating on the biodistribution profile of gold nanoparticles in the rat

(2011) Tiago Morais et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gadolinium Chloride Augments Tumor-Specific Imaging of Targeted Quantum Dots In Vivo

(2010) Parmeswaran Diagaradjane et al.   ACS Nano

In Vivo Biodistribution and Clearance Studies Using Multimodal Organically Modified Silica Nanoparticles

(2010) Rajiv Kumar et al.   ACS Nano

Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles

(2010) Chunbai He et al.   BIOMATERIALS

Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages

(2010) Arnida et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice

(2010) Manabu Kinoshita et al.   JOURNAL OF HEPATOLOGY

Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance

(2010) O. B. Garbuzenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Size-dependent tissue kinetics of PEG-coated gold nanoparticles

(2010) Wan-Seob Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis

(2009) Janie L. Baratta et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Galactosylated LDL Nanoparticles: A Novel Targeting Delivery System To Deliver Antigen to Macrophages and Enhance Antigen Specific T Cell Responses

(2009) Fang Wu et al.   MOLECULAR PHARMACEUTICS

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

Protracted elimination of gold nanoparticles from mouse liver

(2009) Evaldas Sadauskas et al.   Nanomedicine-Nanotechnology Biology and Medicine

Participation of Functionally Different Macrophage Populations and Monocyte Chemoattractant Protein-1 in Early Stages of Thioacetamide-induced Rat Hepatic Injury

(2009) Yoko Mori et al.   TOXICOLOGIC PATHOLOGY

Particle size-dependent organ distribution of gold nanoparticles after intravenous administration

(2008) Wim H. De Jong et al.   BIOMATERIALS

TLR-dependent cross talk between human Kupffer cells and NK cells

(2008) Zhengkun Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY