p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept

Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

(2016) Rui Kamada et al.   BIOPOLYMERS

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

(2016) Alice Soragni et al.   CANCER CELL

(Intrinsically disordered) splice variants in the proteome: implications for novel drug discovery

(2016) Vladimir N. Uversky   Genes & Genomics

Monitoring Ligand-Induced Protein Ordering in Drug Discovery

(2016) Christy R. Grace et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of p53 isoforms and aggregations in cancer

(2016) SeJin Kim et al.   MEDICINE

Aberrant Splicing in Cancer: Mediators of Malignant Progression through an Imperfect Splice Program Shift

(2016) Felipe Andrés Cordero Luz et al.   ONCOLOGY

Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein

(2016) Alexander S. Krois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Modifiers of the p53 Pathway

(2016) Subhasree Basu et al.   Cold Spring Harbor Perspectives in Medicine

The Quest of the Human Proteome and the Missing Proteins: Digging Deeper

(2015) Panga Jaipal Reddy et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

An Acetyl-Methyl Switch Drives a Conformational Change in p53

(2015) Qiong Tong et al.   STRUCTURE

Structural Plasticity of Methyllysine Recognition by the Tandem Tudor Domain of 53BP1

(2015) Qiong Tong et al.   STRUCTURE

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

(2015) Han Dai et al.   Nature Communications

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

(2014) Grzegorz Popowicz et al.   CELL CYCLE

Exceptionally abundant exceptions: comprehensive characterization of intrinsic disorder in all domains of life

(2014) Zhenling Peng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

(2014) Vladimir N. Uversky et al.   CHEMICAL REVIEWS

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Mutant TP53 Posttranslational Modifications: Challenges and Opportunities

(2014) Thuy-Ai Nguyen et al.   HUMAN MUTATION

GermlineTP53Mutations and the Changing Landscape of Li-Fraumeni Syndrome

(2014) Junne Kamihara et al.   HUMAN MUTATION

Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein

(2014) Soheila Emamzadah et al.   JOURNAL OF MOLECULAR BIOLOGY

Extended String Binding Mode of the Phosphorylated Transactivation Domain of Tumor Suppressor p53

(2014) Masahiko Okuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

The structural and functional signatures of proteins that undergo multiple events of post-translational modification

(2014) Vikas Pejaver et al.   PROTEIN SCIENCE

Intrinsically Disordered Proteins: Where Computation Meets Experiment

(2014) Virginia Burger et al.   Polymers

Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

(2013) Marija Buljan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ratio disruption of the Δ133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma

(2013) NICHAPAVEE NUTTHASIRIKUL et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

State of the Human Proteome in 2013 as Viewed through PeptideAtlas: Comparing the Kidney, Urine, and Plasma Proteomes for the Biology- and Disease-Driven Human Proteome Project

(2013) Terry Farrah et al.   JOURNAL OF PROTEOME RESEARCH

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

Ordered Disorder of the Astrocytic Dystrophin-Associated Protein Complex in the Norm and Pathology

(2013) Insung Na et al.   PLoS One

High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort

(2013) Gillian Mitchell et al.   PLoS One

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A decade and a half of protein intrinsic disorder: Biology still waits for physics

(2013) Vladimir N. Uversky   PROTEIN SCIENCE

Unusual biophysics of intrinsically disordered proteins

(2012) Vladimir N. Uversky   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The impact of post-transcriptional regulation in the p53 network

(2012) J. A. Freeman et al.   Briefings in Functional Genomics

Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53

(2012) Lorna Jane Warnock et al.   CANCER BIOLOGY & THERAPY

p53 N-terminal phosphorylation: a defining layer of complex regulation

(2012) L. M. M. Jenkins et al.   CARCINOGENESIS

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop

(2012) Fabio Valenti et al.   CELL CYCLE

Dietary downregulation of mutant p53 levels via glucose restriction

(2012) Olga Catalina Rodriguez et al.   CELL CYCLE

Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition

(2012) Marianne Schimpl et al.   CHEMISTRY & BIOLOGY

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Surf the Post-translational Modification Network of p53 Regulation

(2012) Bo Gu et al.   International Journal of Biological Sciences

Disordered Competitive Recruiter: Fast and Foldable

(2012) Vladimir N. Uversky   JOURNAL OF MOLECULAR BIOLOGY

The State of the Human Proteome in 2012 as Viewed through PeptideAtlas

(2012) Terry Farrah et al.   JOURNAL OF PROTEOME RESEARCH

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

(2012) Marija Buljan et al.   MOLECULAR CELL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis

(2012) Bernard Leroy et al.   NUCLEIC ACIDS RESEARCH

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

p53 isoform profiling in glioblastoma and injured brain

(2012) R Takahashi et al.   ONCOGENE

The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression

(2012) H Bernard et al.   ONCOGENE

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

(2012) John P. Rowell et al.   STRUCTURE

Alternative splicings on p53, BRCA1 and PTEN genes involved in breast cancer

(2011) Naoko Okumura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESpritz: accurate and fast prediction of protein disorder

(2011) Ian Walsh et al.   BIOINFORMATICS

Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity

(2011) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

Unstructural biology coming of age

(2011) Peter Tompa   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of Human SMYD2 Protein Reveals the Basis of p53 Tumor Suppressor Methylation

(2011) Li Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein

(2010) Chul Won Lee et al.   BIOCHEMISTRY

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Archaic chaos: intrinsically disordered proteins in Archaea

(2010) Bin Xue et al.   BMC Systems Biology

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

(2010) I Goldstein et al.   CANCER GENE THERAPY

Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47

(2010) Darren J. Powell et al.   CELL CYCLE

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

(2010) Vladimir N. Uversky   CHEMICAL SOCIETY REVIEWS

Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer

(2010) Benjamin Schumacher et al.   FEBS LETTERS

Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript

(2010) Virginie Marcel et al.   FEBS LETTERS

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

(2010) Roland Hjerpe et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of the p53 pathway by ubiquitin and related proteins

(2010) Andreas Hock et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway

(2010) Ricardo E. Perez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47

(2010) Karima Bourougaa et al.   MOLECULAR CELL

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

p53 isoforms gain functions

(2010) V Olivares-Illana et al.   ONCOGENE

Alternative splicing of p53 and p73: the novel p53 splice variant p53δ is an independent prognostic marker in ovarian cancer

(2010) G Hofstetter et al.   ONCOGENE

LI-FRAUMENI SYNDROME IN A TURKISH FAMILY

(2010) Zeynep Karakas et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

The protein kingdom extended: Ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation

(2010) Konstantin K. Turoverov et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

Two Distinct Motifs within the p53 Transactivation Domain Bind to the Taz2 Domain of p300 and Are Differentially Affected by Phosphorylation†

(2009) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

ANCHOR: web server for predicting protein binding regions in disordered proteins

(2009) Z. Dosztanyi et al.   BIOINFORMATICS

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

(2009) Vladimir N Uversky et al.   BMC GENOMICS

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Finding one's way in proteomics: a protein species nomenclature

(2009) Hartmut Schlüter et al.   Chemistry Central Journal

Modifications of p53: competing for the lysines

(2009) Stephanie Carter et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Modulation of the Oligomerization State of p53 by Differential Binding of Proteins of the S100 Family to p53 Monomers and Tetramers

(2009) Jan van Dieck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

(2009) D P Teufel et al.   ONCOGENE

A unified model of protein dynamics

(2009) H. Frauenfelder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation

(2009) Hanqiao Feng et al.   STRUCTURE

The Isoforms of the p53 Protein

(2009) M. P. Khoury et al.   Cold Spring Harbor Perspectives in Biology

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Prediction of Protein Binding Regions in Disordered Proteins

(2009) Bálint Mészáros et al.   PLoS Computational Biology

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Small Molecular Weight Variants of p53 Are Expressed in Human Melanoma Cells and Are Induced by the DNA-Damaging Agent Cisplatin

(2008) K. A. Avery-Kiejda et al.   CLINICAL CANCER RESEARCH

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

p53 Oligomerization Is Essential for Its C-terminal Lysine Acetylation

(2008) Yoko Itahana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transduction via unstructured protein conduits

(2008) A Keith Dunker et al.   Nature Chemical Biology

Molecular basis of Pirh2-mediated p53 ubiquitylation

(2008) Yi Sheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

(2008) M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer

(2007) Mirko Marabese et al.   EUROPEAN JOURNAL OF CANCER

Differential Recognition of Phosphorylated Transactivation Domains of p53 by Different p300 Domains

(2007) Smarajit Polley et al.   JOURNAL OF MOLECULAR BIOLOGY