(Intrinsically disordered) splice variants in the proteome: implications for novel drug discovery
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Title
(Intrinsically disordered) splice variants in the proteome: implications for novel drug discovery
Authors
Keywords
Alternative splicing, Drug target, Intrinsic disorder, Intrinsically disordered protein, Posttranslational modification, Protein binding, Protein–protein interaction, Splice variant
Journal
Genes & Genomics
Volume 38, Issue 7, Pages 577-594
Publisher
Springer Nature
Online
2016-01-04
DOI
10.1007/s13258-015-0384-0
References
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Note: Only part of the references are listed.- A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variants
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- (2014) Atsushi Kurotani et al. BIOINFORMATICS
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- (2014) J Chen et al. ONCOGENE
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- (2014) Carmen A. Banuelos et al. PLoS One
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- (2014) Jonathan M. Toung et al. PLoS One
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- (2014) Vikas Pejaver et al. PROTEIN SCIENCE
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- (2014) Giuseppe Biamonti et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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- (2013) Sophia Adamia et al. CLINICAL CANCER RESEARCH
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- (2013) Sophia Adamia et al. CURRENT CANCER DRUG TARGETS
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- (2013) Guo-Lin Chen et al. PLoS One
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- (2013) A. Reyes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) S. Park et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
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- (2013) Maria de Lourdes Coelho Ribeiro et al. PeerJ
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- (2011) H. Jane Dyson QUARTERLY REVIEWS OF BIOPHYSICS
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- (2011) Eva Schad et al. GENOME BIOLOGY
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- (2010) Judith Bellemare et al. JOURNAL OF PATHOLOGY
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- (2010) Caroline Raynal et al. Molecular Cancer
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- (2009) Melissa M. Pentony et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
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- (2009) J. B. Li et al. SCIENCE
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- (2008) Jenilyn J. Virrey et al. AMERICAN JOURNAL OF PATHOLOGY
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- (2008) Christopher J Oldfield et al. BMC GENOMICS
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